Effects of Linear Alkylbenzene Sulfonate Orally Administered to Pregnant Mice on the Pregnant Mice and Their Fetuses

Shiobara, Shoichi; Imahori, Akira

doi:10.3358/shokueishi.17.295

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding previous works on teratogenicity and reproductive effects of DHA in mouse and rats, it is difficult to conclude on the concordance of the results because data have been found only for sodium dehydroacetate. Indeed, the effect of sodium dehydroacetate orally administered to pregnant mice during pregnancy has been measured by Shiobara et al After feeding pregnant mice on days 6–15 of gestation, fetal lethality significantly increased to 50, 100 and 200 mg/kg/day . In another study, conducted by Tanaka et al, oral administration during days 6–17 of gestation at 0, 25, 50 and 100 mg/kg showed body weight loss and some skeletal variations for the higher doses (50 and 100 mg/kg).…”

Section: Resultsmentioning

confidence: 97%

Ultraviolet–visible phototransformation of dehydroacetic acid – Structural characterization of photoproducts and global ecotoxicity

Vaugelade

Nicol

Vujović

et al. 2018

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

With the exception of one photoproduct, the structures proposed for the photoproducts on the basis of mass spectral interpretation have not been reported in previous studies. All photoproducts, with the exception of dimers, were detected after irradiation in the cosmetic emulsion. This result shows that personal care products containing DHA must be protected from direct sunlight to prevent photodegradation.

show abstract

Section: Resultsmentioning

confidence: 97%

Ultraviolet–visible phototransformation of dehydroacetic acid – Structural characterization of photoproducts and global ecotoxicity

Vaugelade

Nicol

Vujović

et al. 2018

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

Final Report on the Safety Assessment of Sodium Dodecylbenzenesulfonate/TEA-Dodecylbenzenesulfonate/ Sodium Decylbenzenesulfonate

1993

Journal of the American College of Toxicology

View full text Add to dashboard Cite

The oral LD50 for Sodium Dodecylbenzenesulfonate (SDDBS) in rats was 1.26 g/kg. No significant toxic effects were observed when rats were given oral doses of 1000 ppm SDDBS in water. No systemic toxicity was observed in rabbits given dermal applications of ≤10% SDDBS to abraded skin for 28 days; severe dermal irritation was observed at the application site. Mild necrosis of intestinal mucosa with hemosiderosis of the spleen, liver, and kidneys was observed in rats given a varying dosage of 2.5–5.0 ml/kg/day of a formulation containing 15% SDDBS for a total of 22 weeks; lesions were not observed for rats given 0.5 ml/kg/day. Renal damage was observed in rats dosed orally with ≤0.6% SDDBS for 6 months. For dogs fed ≤1000 mg/kg/day of a formulation containing 15% SDDBS in the diet for 6 months, hemorrhagic necrosis of the intestine and infiltration of inflammatory cells were observed at 10 mg/kg and hemosiderosis of the liver and spleen was observed at 100 and 1000 mg/kg. SDDBS, adjusted to 15% active and a p H of 7.0, applied to intact and abraded sites was severely irritating. A solution containing 1.9% SDDBS and 1.9% tallow alkyl ethoxylate sulfate was moderately irritating to the skin of rabbits. This compound was not a sensitizer when tested at low concentrations. Concentrations of ≥5% Linear Alkylbenzene Sulfonate (LAS) were irritants to the eyes of rabbits; ≤0.1 % LAS produced mild to no irritation. (LAS is a commercial preparation that has the average molecular weight of SDDBS.) No reproductive effects were produced by dermal application of LAS or TEA-DDBS or by oral administration of LAS. The results of mutagenic assays using SDDBS were negative. Dermal carcinogenicity studies using LAS and TEA-DDBS and oral carcinogenicity studies using SDDBS and LAS were negative. On the basis of the animal and clinical data presented in this report, it is concluded that Sodium Dodecylbenzenesulfonate, TEA-Dodecylbenzenesulfonate, and Sodium Decylbenzenesulfonate are safe as cosmetic ingredients in the present practices of use. The full report includes a discussion on how the various types of safety test data were interpreted, both individually and collectively.

show abstract

Effects of Linear Alkylbenzene Sulfonate Orally Administered to Pregnant Mice on the Pregnant Mice and Their Fetuses

Cited by 2 publications

References 0 publications

Ultraviolet–visible phototransformation of dehydroacetic acid – Structural characterization of photoproducts and global ecotoxicity

Ultraviolet–visible phototransformation of dehydroacetic acid – Structural characterization of photoproducts and global ecotoxicity

Final Report on the Safety Assessment of Sodium Dodecylbenzenesulfonate/TEA-Dodecylbenzenesulfonate/ Sodium Decylbenzenesulfonate

Contact Info

Product

Resources

About