Effects of lipid bilayer encapsulation and lipid composition on the catalytic activity and colloidal stability of hydrophobic palladium nanoparticles in water

Ortega, Dominick D; Pavlakovich, Nicholas; Shon, Y.

doi:10.1039/d2ra03974e

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…These reflections may be due to the existence of long chain organic phase (Figure 2b). 36 The crystallite size of these NPs was found to be 48.34 nm from Scherrer equation. Hydrodynamic raddi (r H , nm), polydispersity index (PDI), and surface potential (ξ, mV) of methanolic solution of Pd‐ L4 NPs as obtained from dynamic light scattering (DLS) analysis were found to be 26.61 nm, 0.0134 and 3.59 mV, thereby suggesting their monodispersed nature, smaller size, incipient stability, and near positive surface potential of NPs (Figure 2c,d).…”

Section: Materials Characterizationmentioning

confidence: 94%

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gupta,

Srivastava,

V.S. Ranganath

2023

Applied Organom Chemis

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A series of Gemini surfactants (GSs) were prepared by reacting alkyl bromides with N,N,N′,N′‐tetramethyl ethylenediamine. Various alkyl bromides used in for the preparation of GSs are 1,3‐dibromo ethane, 1,3‐dibromoethane, 1‐Bromohexane, 1‐Bromooctane, 1‐Bromooctadecane and 1‐Bromooctadodecane. Different solvents and temperatures were investigated for the formation of gels of prepared GSs. Among all, 1‐Bromooctane, 1‐Bromooctadecane‐derived GSs formed organogels. Thus, synthesized long‐chain organogels have been used to stabilize Pd NPs. The Pd NPs formation initially confirmed through Ultraviolet‐visible, Scanning Electron Microscopy, and Atomic Force Micrograph studies. Later Fourier Tansform Infra Red, Thermo Gravimetric Analysis, and Zeta potential studies were also carried out to understand their properties extensively. The Pd NPs stabilized by GSs have been identified as a potential catalyst in the reductive N‐acetylation of nitroaromatics at room temperature. The N‐acetylated products were obtained in good yields in an aqueous medium. In addition, the potentiality of our catalyst has been also evaluated in the reduction of nitroaromatics in an aqueous medium, which is a green protocol. Further, the semi‐empirical geometry optimizations of active GS gel confirmed the dihedral angle of 59° in between the two octyl moieties calculated from computational studies. The rheological properties such as amplitude sweeping, viscosity shear profile of the gel have also been studied.

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Section: Materials Characterizationmentioning

confidence: 94%

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gupta,

Srivastava,

V.S. Ranganath

2023

Applied Organom Chemis

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“…[69] Recently, lipid nanoparticle assemblies have also been shown to house catalytically active palladium nanoparticles. [70] These assemblies provide the means to both ensure the solubilisation of reaction components and their uptake into cells; however, this strategy could fall short for more polar substrates.…”

Section: Physical Protection Of the Catalystmentioning

confidence: 99%

“…Similarly, liposomes and lipid nanoparticles (LNPs) generate an interior hydrophobic cavity surrounded by a lipid bilayer, within which hydrophobic and non‐cell permeable cargo can be delivered into cells [69] . Recently, lipid nanoparticle assemblies have also been shown to house catalytically active palladium nanoparticles [70] . These assemblies provide the means to both ensure the solubilisation of reaction components and their uptake into cells; however, this strategy could fall short for more polar substrates.…”

Section: Compatibility Challenges and Potential Future Strategiesmentioning

confidence: 99%

Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions

James

Bruin

Reek³

2023

Angew Chem Int Ed

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The importance of transition metal catalysis is exemplified by its wide range of applications, for example in the synthesis of chemicals, natural products, and pharmaceuticals. However, one relatively new application is for carrying out new‐to‐nature reactions inside living cells. The complex environment of a living cell is not welcoming to transition metal catalysts, as a diverse range of biological components have the potential to inhibit or deactivate the catalyst. Here we review the current progress in the field of transition metal catalysis, and evaluation of catalysis efficiency in living cells and under biological (relevant) conditions. Catalyst poisoning is a ubiquitous problem in this field, and we propose that future research into the development of physical and kinetic protection strategies may provide a route to improve the reactivity of catalysts in cells.

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Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions

James

Bruin

Reek³

2023

Angewandte Chemie

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Effects of lipid bilayer encapsulation and lipid composition on the catalytic activity and colloidal stability of hydrophobic palladium nanoparticles in water

Abstract: Hydrophobic micellization effect and dynamic lipid bilayer–substrate interactions enhance the catalytic activity of hydrophobic Pd nanoparticles embedded in liposomal assemblies.

Cited by 4 publications

References 60 publications

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Gemini surfactant‐stabilized Pd nanoparticles: Synthesis, characterization, and catalytic application in the reduction and reductive acetylation in the water solvent

Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions

Transition Metal Catalysis in Living Cells: Progress, Challenges, and Novel Supramolecular Solutions

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