Effects of lipids on mitochondrial functions

Mårtensson, Christoph U.; Doan, Kim Nguyen; Becker, Thomas

doi:10.1016/j.bbalip.2016.06.015

Cited by 108 publications

(91 citation statements)

References 177 publications

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“…It should be added that we showed in mstn KO gastrocnemius a tendency towards the reduction of linoleic acid (18:2n-6), the most abundant fatty acid in CL [64]. As a close interplay between CL biosynthesis and oxidative phosphorylation is recognized [24], our results raise the question of the link with the compromised bioenergetic capacity observed in this hypertrophic muscle. We recognize that direct evidence is still missing, and should be discussed with caution.…”

Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 53%

“…The proper lipid composition of the membranes is crucial for membrane-bound protein machineries to maintain optimal mitochondrial biogenesis and function. The recent review of Martensson et al, 2016 illustrated that phospoholipids affect outer (TOM complex, MIM, SAM) and inner (TIM23, TIM22 and OXA) membrane protein translocases and thus play a crucial role in mitochondrial protein import [24].The role of phospholipids on mitochondria protein is also highlighted by their impact on respiratory chain supercomplexes [24]. In these studies, one phospholipid, cardiolipin (CL) attracted scientific attention.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Phospholipids affect function of protein machineries involved in respiratory metabolism, protein import, membrane architecture and mitochondrial dynamics [24]. At this point, we…”

Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 99%

“…In DMD If it is difficult to distinguish between a causal role of cardiolipin and a correlative effect, in one study, replenishment with cardiolipin of hypothyroid mitochondria restored the activity of cytochrome oxidase to control levels [60]. Synthesized in the inner mitochondrial membrane, nascent CL undergoes a remodelling process to form the mature CL [24]. Our results on enzymes involved in CL formation indicated that MSTN deficiency likely negatively affected synthesis, rather than remodeling process, that induced the lower abundance of CL.…”

Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 99%

“…In these studies, one phospholipid, cardiolipin (CL) attracted scientific attention. Mostly present in the inner mitochondrial membrane, CL undergoes two main phases for its activity [24,25]. The first is its biosynthesis that takes place on the matrix face of the inner mitochondrial membranes, pathway catalysed by numerous and successive enzymes as Tam41, Pgs1, PTPMT1 and finally by CL synthase (also called Crd1), to form premature (nascent) CL.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

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Myostatin deficiency is associated with lipidomic abnormalities in skeletal muscles

Baati

Feillet‐Coudray

Fouret

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Myostatin (Mstn) deficiency leads to skeletal muscle overgrowth and Mstn inhibition is considered as a promising treatment for muscle-wasting disorders. Mstn gene deletion in mice also causes metabolic changes with decreased mitochondria content, disturbance in mitochondrial respiratory function and increased muscle fatigability. However the impact of MSTN deficiency on these metabolic changes is not fully elucidated. Here, we hypothesized that lack of MSTN will alter skeletal muscle membrane lipid composition in relation with pronounced alterations in muscle function and metabolism. Indeed, phospholipids and in particular cardiolipin mostly present in the inner mitochondrial membrane, play a crucial role in mitochondria function and oxidative phosphorylation process. We observed that Mstn KO muscle had reduced fat membrane transporter levels (FAT/CD36, FABP3, FATP1 and FATP4) associated with decreased lipid oxidative pathway (citrate synthase and β-HAD activities) and impaired lipogenesis (decreased triglyceride and free fatty acid content), indicating a role of mstn in muscle lipid metabolism. We further analyzed phospholipid classes and fatty acid composition by chromatographic methods in muscle and mitochondrial membranes. Mstn KO mice showed increased levels of saturated and polyunsaturated fatty acids at the expense of monounsaturated fatty acids. We also demonstrated, in this phenotype, a reduction in cardiolipin proportion in mitochondrial membrane versus the proportion of others phospholipids, in relation with a decrease in the expression of phosphatidylglycerolphosphate synthase and cardiolipin synthase, enzymes involved in cardiolipin synthesis. These data illustrate the importance of lipids as a link by which MSTN deficiency can impact mitochondrial bioenergetics in skeletal muscle. (Résumé d'auteur

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Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 53%

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…Phospholipids affect function of protein machineries involved in respiratory metabolism, protein import, membrane architecture and mitochondrial dynamics [24]. At this point, we…”

Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 99%

Section: Myostatin and Membrane Phospholipids Compositionmentioning

confidence: 99%

Section: Accepted M Manuscriptmentioning

confidence: 99%

See 3 more Smart Citations

Myostatin deficiency is associated with lipidomic abnormalities in skeletal muscles

Baati

Feillet‐Coudray

Fouret

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

View full text Add to dashboard Cite

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Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

et al. 2019

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IntroductionCocaine dependence affects millions of individuals worldwide; however, there are no pharmacotherapeutic and/or diagnostic solutions. Recent evidence suggests a role for lipid signaling in the development and maintenance of addiction, highlighting the need to understand how lipid remodeling mediates neuroadaptation after cocaine exposure.MethodsThis study utilized shotgun lipidomics to assess cocaine‐induced lipid remodeling in rats using a novel behavioral regimen that incorporated multiple sessions of extinction training and reinstatement testing.ResultsMass spectrometric imaging demonstrated widespread decreases in phospholipid (PL) abundance throughout the brain, and high‐spatial resolution matrix‐assisted laser desorption/ionization Fourier‐transform ion cyclotron resonance mass spectrometry indicated hippocampus‐specific PL alterations following cocaine exposure. We analyzed the expression of genes involved in hippocampal lipid metabolism and observed region‐specific regulation. In addition, we found that cocaine exposure differentially regulates mitochondrial biogenesis in the brain.ConclusionsThis work presents a comprehensive lipidomic assessment of cocaine‐induced lipid remodeling in the rat brain. Further, these findings indicate a potential interplay between CNS energetics and differential lipid regulation and suggest a role for cocaine in the maintenance of energy homeostasis.

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Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

et al. 2018

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Adaptive immunity critically depends on cell migration combined with clonal selection and rapid expansion of rare lymphocytes recognising their cognate antigen in secondary lymphoid organs. It has since become apparent that large populations of T cells are maintained in tissues, which do not migrate throughout the body and do not require clonal expansion. Murine intraepithelial lymphocytes (IELs), located in the skin and small intestines, are maintained in a state of semi‐activation, in marked contrast to the quiescent condition naive and memory lymphocytes are kept in. The poised activation state of IELs, their location in the top layers of barrier organs and close bidirectional interactions with epithelial cells suggests IELs are part of a sophisticated strategy of immune‐surveillance and compartmentalisation of immune responses. Recent murine studies have reemphasised the influence of metabolism in T‐cell activation and differentiation, with different metabolic make up of naive, effector and memory T cells. Here we highlight and discuss some of the current insights on immunometabolism of IELs, with emphasis on novel data contrasting how IELs may be maintained in a semi‐activated state and may become fully functional compared with conventional T cells.

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Effects of lipids on mitochondrial functions

Cited by 108 publications

References 177 publications

Myostatin deficiency is associated with lipidomic abnormalities in skeletal muscles

Myostatin deficiency is associated with lipidomic abnormalities in skeletal muscles

Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

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