Effects of lipoic acid and n -3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause

Schüller, Ártur Krumberg; Canata, Diego Antonio Mena; Hackenhaar, Fernanda Schäfer; Engers, Vanessa Krüger; Heemann, Fernanda Maciel; Putti, Jordana Salete; Salomon, Tiago Boeira; Benfato, Mara da Silveira

doi:10.1016/j.pharep.2017.10.006

Cited by 12 publications

(5 citation statements)

References 63 publications

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“…The ovariectomy-induced menopause model in female rats is widely used to study biological processes and test new interventions that can minimize harmful effects associated with menopause (3,24,32). The experimental model most commonly used to observe the menopause period is a bilateral ovarian surgery (34,35). OS is a condition characterized by an imbalance between pro-oxidant molecules and antioxidant defenses, including reactive oxygen and nitrogen species.…”

Section: Resultsmentioning

confidence: 99%

Boric acid supplementation affects antioxidant activity in ovariectomized female rats

TEKELI¹,

ASICI²,

BILDIK³

2022

Medycyna Weterynaryjna

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This study aimed to investigate the protective effect of boric acid (BA) supplementation against oxidative stress (OS) in ovariectomized rats. A total of 48 nonpregnant female Wistar albino rats (180-250 g) were used in the experiment. The rats were divided into six equal groups (n = 8): Control, OVX, OVX + 5 mg/kg BA (OVX + BA5), OVX + 10 mg/kg BA (OVX + BA10), 5 mg/kg BA (BA5), and 10 mg/kg BA (BA10). The rats were intraperitoneally anesthetized with a combination of ketamine hydrochloride (85 mg/kg) and xylazine (10 mg/kg) and underwent a bilateral ovariectomy. Supplementation with 5 mg/kg and 10 mg/kg BA via oral gavage was started 2 weeks after ovariectomy and continued for 20 days. Catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione (GSH), and malondialdehyde (MDA) levels in the liver, kidney, and brain tissues of rats were analyzed by the spectrophotometric method. MDA concentrations in the liver tissue was increased in the OVX rats compared to the control group (p <0.05). Liver GST activity was significantly decreased in the OVX rats, but it was increased with 5 mg/kg and 10 mg/kg BA supplementation (p <0.05). Mean kidney GSH, GPx, and CAT activities in the OVX rats were increased with 5 mg/kg and 10 mg/kg BA supplementation (p <0.05). In the brain tissue, GST activity was increased in the OVX rats treated with 10 mg/kg BA (p <0.05). These results indicate that BA supplementation can enhance antioxidant defense mechanisms against OS after ovariectomy in female rats.

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Section: Resultsmentioning

confidence: 99%

Boric acid supplementation affects antioxidant activity in ovariectomized female rats

TEKELI¹,

ASICI²,

BILDIK³

2022

Medycyna Weterynaryjna

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“…Among them, ovariectomized models are more commonly used [ 28 , 29 ]. Several studies have also shown that estrogen receptor alpha (ER α ) is associated with weight control and lipid accumulation [ 7 , 30 ]. As in the study of Palmisano and Koshy et al, fatty liver is induced in ovariectomized rodents, and the improvement effect of fatty liver has been verified when treated with similar estrogens such as estrogen or phytoestrogens [ 8 , 10 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Menopausal women experience significant changes in hormones due to a decrease in the female hormone estrogen. Postmenopausal changes in female hormones cause various symptoms such as osteoporosis and cardiovascular disease, thereby changing the quality of life [2,[5][6][7][8]. In menopause, estrogen is decreased specifically, cholesterol is accumulated in the body, and fatty liver is induced.…”

Section: Introductionmentioning

confidence: 99%

Improvement in Menopause‐Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats

Chang

Kim

2020

Evidence-Based Complementary and Alternative Medicine

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Postmenopausal women have an increased risk of developing nonalcoholic fatty liver disease (NAFLD). We formulated a combination of three herb mixtures (HPC03) and observed lipid-lowering efficacy. HepG2 cells were treated with oleic acid to induce an NAFLD model (in vitro). Also, we investigated potential of HPC03 in an ovariectomize- (OVX-) induced NAFLD model (in vivo). We separated the mice into six groups, as follows: SHAM, OVX, OVX + β-estradiol, and OVX + HPC03 (50, 100, and 200 mg/kg). Rats were administered with/without HPC03 for 12 weeks. HPC03 dose dependently inhibited the lipid accumulation involved in lipogenesis in HepG2 cells. The body weight, fat mass, and weights of the liver were decreased in the OVX group than that in the other groups. HPC03 had decreased adiposity that was induced by OVX. HPC03 treatment reduced liver lipid deposition and prevented the increase in serum and liver triglyceride export when there was a deficiency in estradiol. HPC03 improves OVX-induced fatty liver and lipid metabolism. These findings suggest that HPC03 from postmenopausal women has a protective effect during NAFLD conditions.

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“… 123 It is a key cofactor in the construction of vital metabolic multienzyme complexes, including pyruvate dehydrogenase and the glycine cleavage system. 123 It is also a strong antioxidant 1 , 119 , 124 , 125 and anti-inflammatory 109 , 119 , 125 agent capable of activating and modulating signal transduction pathways, 109 , 119 , 126 upregulating the expression of nerve growth factor, and augmenting the conduction velocity of motor nerves. 127 …”

Section: α-Lipoic Acid L -Carnitine and Butyratementioning

confidence: 99%

A New Approach to Treating Neurodegenerative Otologic Disorders

Moos

Faller

Glavas

et al. 2018

BioResearch Open Access

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Hearing loss, the most common neurological disorder and the fourth leading cause of years lived with disability, can have profound effects on quality of life. The impact of this “invisible disability,” with significant consequences, economic and personal, is most substantial in low- and middle-income countries, where >80% of affected people live. Given the importance of hearing for communication, enjoyment, and safety, with up to 500 million affected globally at a cost of nearly $800 billion/year, research on new approaches toward prevention and treatment is attracting increased attention. The consequences of noise pollution are largely preventable, but irreversible hearing loss can result from aging, disease, or drug side effects. Once damage occurs, treatment relies on hearing aids and cochlear implants. Preventing, delaying, or reducing some degree of hearing loss may be possible by avoiding excessive noise and addressing major contributory factors such as cardiovascular risk. However, given the magnitude of the problem, these interventions alone are unlikely to be sufficient. Recent advances in understanding principal mechanisms that govern hearing function, together with new drug discovery paradigms designed to identify efficacious therapies, bode well for pharmaceutical intervention. This review surveys various causes of loss of auditory function and discusses potential neurological underpinnings, including mitochondrial dysfunction. Mitochondria mitigate cell protection, survival, and function and may succumb to cumulative degradation of energy production and performance; the end result is cell death. Energy-demanding neurons and vestibulocochlear hair cells are vulnerable to mitochondrial dysfunction, and hearing impairment and deafness are characteristic of neurodegenerative mitochondrial disease phenotypes. Beyond acting as cellular powerhouses, mitochondria regulate immune responses to infections, and studies of this phenomenon have aided in identifying nuclear factor kappa B and nuclear factor erythroid 2-related factor 2/antioxidant response element signaling as targets for discovery of otologic drugs, respectively, suppressing or upregulating these pathways. Treatment with free radical scavenging antioxidants is one therapeutic approach, with lipoic acid and corresponding carnitine esters exhibiting improved biodistribution and other features showing promise. These compounds are also histone deacetylase (HDAC) inhibitors, adding epigenetic modulation to the mechanistic milieu through which they act. These data suggest that new drugs targeting mitochondrial dysfunction and modulating epigenetic pathways via HDAC inhibition or other mechanisms hold great promise.

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Effects of lipoic acid and n -3 long-chain polyunsaturated fatty acid on the liver ovariectomized rat model of menopause

Cited by 12 publications

References 63 publications

Boric acid supplementation affects antioxidant activity in ovariectomized female rats

Boric acid supplementation affects antioxidant activity in ovariectomized female rats

Improvement in Menopause‐Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats

A New Approach to Treating Neurodegenerative Otologic Disorders

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