Effects of Lipoic Acid on Plasma Metabolites and Metabolic Response to Intravenous Injection of Isoproterenol in Broilers

Hamano, Yoshio; Kamota, Yoko; Sugawara, Shichiro

doi:10.5713/ajas.2000.653

Cited by 8 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study confirmed that LA stimulated plasma glucose increases when birds receive a continuous infusion of isoproterenol [9]. Consequently, the CLE-stimulated glycogenolytic response was not associated with LA, although the b-adrenergic response of plasma glucose is thought to be even more sensitive in the CLE challenge than in the case of a single injection of isoproterenol [10]. Therefore, the present result indicates that LA possesses a possible effect leading to reduced blood glucose but does not affect the CLE-induced rapid glycogenolysis responsible for hyperglycemia in chickens.…”

Section: Combined Effects Of Dietary La and Cle On Growth Performancesupporting

confidence: 63%

“…has been previously observed in 6-weekold broiler chickens with LA (50 mg . kg -1 ) but not in 4-week-old birds [9,10]. Taken together with this previous finding, unless dietary LA is administered at a higher level to 4-week-old birds, a distinctive effect of LA on plasma metabolites could not be confirmed.…”

Section: Combined Effects Of Dietary La and Cle On Growth Performancementioning

confidence: 49%

“…On the contrary, dietary LA supplementation enhanced the plasma nonesterified fatty acid (NEFA) level and the rate of in vitro hepatic oxygen consumption and decreased plasma TAG in the chicken, although the effects were dependent upon the dose level and age-related metabolic state [9]. A recent study has also confirmed a decrease in plasma total cholesterol with LA feeding [10]. Moreover, when its administration level is higher than previously used (5 or 50 mg .…”

mentioning

confidence: 54%

“…In relation to hormonal action, the author demonstrated that the dietary administration of LA facilitates the response of plasma glucose and NEFA to intravenous infusion of a non-selective b-adrenergic agonist, isoproterenol, in broilers [9,10]. In domestic animals, clenbuterol (CLE), a selective b 2 -adrenergic agonist, is well known to be a potent growth promoter that increases muscle mass and protein deposition or decreases adipose tissue accretion [3,5,15,16,20].…”

mentioning

confidence: 99%

“…Moreover, when its administration level is higher than previously used (5 or 50 mg . kg diet -1 ) [9,10], whether the response of chicken performance and lipid metabolism to dietary LA is facilitated or different is currently unclear.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Hamano

2002

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

Section: Combined Effects Of Dietary La and Cle On Growth Performancesupporting

confidence: 63%

Section: Combined Effects Of Dietary La and Cle On Growth Performancementioning

confidence: 49%

mentioning

confidence: 54%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Hamano

2002

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

Continuous infusion of lipoic acid rapidly reduces plasma β-hydroxybutyrate with elevation of non-esterified fatty acids in broiler chickens

Hamano

2007

Br J Nutr

View full text Add to dashboard Cite

The present study was conducted to determine the effects of a-lipoic acid (ALA) on fatty acid mobilisation and ketone body production in female broiler chickens. In the first experiment, chickens received an intravenous infusion of ALA (0, 25 or 50 mg/kg per h) for 90 min. Blood was drawn at 30 min intervals, and plasma glucose, NEFA, free glycerol and hydroxybutyrate were analysed. In the second experiment, ALA (100 mg/kg per h) was continuously infused to chickens fed or fasted for at least 24 h. Changes in plasma metabolites for 90 min were determined. In the first experiment, as shown by the response area, ALA infusion did not affect plasma glucose but increased (P, 0·05) plasma NEFA, regardless of the dose level. In contrast, plasma hydroxybutyrate was reduced at the lower infusion rate (P,0·05). No significant changes in plasma free glycerol were observed. In experiment 2, ALA stimulated both plasma glucose (P,0·01) and NEFA (P, 0·001) and the responses were greater than those of controls, regardless of the feeding state. The interaction between ALA and the feeding condition had a significant effect on plasma hydroxybutyrate (P,0·01). ALA reduced plasma hydroxybutyrate, and this response was greater in the fasted birds than in those fed. Therefore, the present study found a lowering effect of ALA on plasma hydroxybutyrate level and suggests that the ALA-induced plasma NEFA increment was attributable to decreased hepatic fatty acid oxidation in chickens.Hydroxybutyrate: Lipoic acid: Lipolysis

show abstract

Effects of dietary lipoic acid on plasma lipid,in vivoinsulin sensitivity, metabolic response to corticosterone andin vitrolipolysis in broiler chickens

Hamano¹

2006

Br J Nutr

View full text Add to dashboard Cite

The present study consisted of two experiments. The first experiment was conducted to determine the effects of lipoic acid (ALA; 200 mg/kg) on plasma lipids and insulin sensitivity of whole-body tissue in broilers treated with or without corticosterone (5 mg/kg). Chickens received these agents from 2 to 5 weeks of age in a 2 £ 2 factorial arrangement. Thereafter, from 39 to 42 d of age, insulin sensitivity was estimated using the euglycaemic and hyperinsulinaemic clamp technique. Experiment 2 examined whether ALA supplementation for 5 weeks (400 mg/kg) would alter short-chain acyl-CoA concentration in the liver and in vitro lipolysis of an adipose tissue slice, in relation to noradrenaline (10 mM) supplementation. In experiment 1, ALA had no effect on the corticosterone-induced negative growth performance. ALA lowered plasma glucose level (P,0·05) and, in contrast, increased triacylglycerol level (P,0·05). These responses to ALA had, however, no interrelationship with corticosterone. The rate of glucose uptake of whole-body tissue was enhanced in the ALA-fed chickens (P, 0·05), regardless of corticosterone treatment. In experiment 2, ALA increased only the plasma free glycerol concentration (P,0·01). The rate of free glycerol release from an adipose tissue slice was enhanced by ALA feeding (P, 0·05) but was not affected by noradrenaline supplementation. This study suggests that ALA stimulates the insulin sensitivity of tissues regardless of corticosterone-dependent metabolism and that the ALA-induced fatty acid metabolism of broilers differs between the liver and adipose tissue.

show abstract

Effects of Lipoic Acid on Plasma Metabolites and Metabolic Response to Intravenous Injection of Isoproterenol in Broilers

Cited by 8 publications

References 0 publications

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Influence of lipoic acid on lipid metabolism and ?-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Continuous infusion of lipoic acid rapidly reduces plasma β-hydroxybutyrate with elevation of non-esterified fatty acids in broiler chickens

Effects of dietary lipoic acid on plasma lipid,in vivoinsulin sensitivity, metabolic response to corticosterone andin vitrolipolysis in broiler chickens

Contact Info

Product

Resources

About