Effects of Lipophilic and Hydrophilic leaf extracts of Portulaca oleracea Linn. (Purslane) on male reproductive parameters in albino rats

Obinna, Victoria C.; Kagbo, Hope Delesi; Agu, Gabriel O.

doi:10.5455/ajpbp.20190124101830

Cited by 11 publications

(12 citation statements)

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“…In addition, recent studies reported a decrease in mean seminiferous tubule diameter and sperm count and motility following streptozotocin administration [40][41][42]. Our results show that PO extract remarkably improved the histopathological changes in the testicular tissue and increased the seminiferous tubule diameter; these results are in accordance with previous reports that demonstrated a protective effect of PO extracts in sperm count and testosterone level in male albino rats [40,[43][44][45].…”

Section: Discussionsupporting

confidence: 92%

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

et al. 2022

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Background: Type-one diabetes (T1D), a chronic autoimmune disease with marked inflammatory responses, is associated with infertility complications and implications. Based on the anti-diabetic, antioxidant, and anti-hyperlipidemic potential of Portulaca oleracea (PO), this study aimed to evaluate the protective effect of this plant extract on streptozotocin-induced type-I-diabetes-associated reproductive system dysfunction and inflammation. Methods: Male rats were randomly divided into four experimental groups: control, diabetic, and treatment/s (PO extract at 100 or 300 mg/kg/daily). Then food and water consumption, body, testis and epididymis weights, histopathological evaluation, seminiferous tubules diameter, sperm count and motility, glucose levels, sex hormones, and inflammatory and oxidative stress markers were evaluated. Results: Our results showed that streptozotocin-induced diabetes significantly increased food and water consumption; increased glucose, MDA, TGF-β1, and TNF-α levels; and decreased the seminiferous tubules diameter, sperm count and motility, levels of LH, testosterone, total thiol, VEGF, and SOD activity. Interestingly, PO extract (phytochemically characterized by using liquid chromatography–mass spectrometry to detect bioactive molecules) significantly ameliorated these parameters and histopathological indexes’ damage in rats. Conclusion. Even if more preclinical assessments are needed to better characterize the mechanism/s of action, the results of this study will pave the way for the rational use of PO on diabetic-associated clinical complications and implications.

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Section: Discussionsupporting

confidence: 92%

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

et al. 2022

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“…Our findings agree with the reports by some studies which also showed a significant reduction in sperm motility, count, and viability as a result of the administration of crude PO extracts (1,13). However, a recent study observed a significant increase in sperm count in their study after the administration of both lipophilic and hydrophilic extracts of PO even in the presence of reduced serum TT (23). This differing outcome remains unclear.…”

Section: Thesupporting

confidence: 91%

Reproductive toxicity potentials of methanolic extract of Portulaca oleracea in male rats: An experimental study

Okafor

Nnamah

Ahiatrogah

et al. 2021

IJRM

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Background: Purslane is an edible widely distributed shrub and one of the herbs used in decoctions for the treatment of different ailments including infertility. However, there is a shortage of evidence to validate its reproductive effects. Objective: To investigate the effect of methanolic extract of Portulaca oleracea (MEPO) on the reproductive system of male rats. Materials and Methods: Fifteen 10-wk old male Wistar rats with an average weight of 183 gr were randomly divided into three groups (n = 5/each). Group A (the control group) received distilled water only; group B received 400 mg/kg MEPO; and group C received 800 mg/kg MEPO for 14 days. The animals fasted overnight after the 14th day of administration and euthanized by cervical dislocation. Blood samples, sperm, testes, and epididymis were collected for serum hormones, sperm, and histological analyses. Results: There was no significant change in the serum luteinizing hormone and testosterone levels across all groups when compared to the control. However, group C showed a significant increase (p = 0.020) in follicle-stimulating hormone levels when compared to the control. There was a significant reduction (p = 0.006) in the sperm count in group C when compared with the control group. There was also a significantly reduced (p = 0.003) sperm motility in MEPO-treated groups compared to the control. While the testis showed no abnormalities in its histoarchitecture across groups, the epididymis showed some blood congestion in MEPO-treated groups. Conclusion: Portulaca oleracea showed the ability to reduce sperm count and motility at higher doses. Key words: Portulaca oleracea, Purslane, Testis, Epididymis, Rat, Sperm motility.

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“…In our previous studies where the preliminary phytochemical screening of lipophilic and hydrophilic leaf extracts of P.oleracea were carried out, it was found that the lipophilic extract could not dissolve in water due to its highly lipophilic nature, and as such allowed for very few tests, out of which only the test for triterpenoids/steroids was positive. 16 The hydrophilic extract, on the other hand, showed the presence of alkaloids, carbohydrates, saponins, triterpenoids/steroids, anthraquinone, and cardiac glycosides. 17 The decline in the concentration of gonadotropins as recorded in this study may not be unconnected with the presence of triterpenoids/steroids in the extracts, which result is similar to our earlier finding where the hydrophilic leaf extract of P.oleracea decreased the testosterone level in male albino rats.…”

Section: Discussionmentioning

confidence: 98%

“… 17 The decline in the concentration of gonadotropins as recorded in this study may not be unconnected with the presence of triterpenoids/steroids in the extracts, which result is similar to our earlier finding where the hydrophilic leaf extract of P.oleracea decreased the testosterone level in male albino rats. 16 According to Qasimi et al. , 18 phytosteroids (plant steroids) have been shown to be associated with endocrine-disruption in laboratory animals.…”

Section: Discussionmentioning

confidence: 99%

Lipophilic and hydrophilic leaf extracts of Portulaca oleracea (Purslane) disrupts female sex hormones in albino rats (Rattus norvegicus)

Obinna

Kagbo

Agu

2021

Journal of Traditional and Complementary Medicine

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Background and aim Decoctions and infusions from the aerial parts of Portulaca oleracea Linn., especially the leaves and stems, are used by traditional medicine practitioners in Nigeria to enhance fertility in humans. The scarcity of literature on the use of this plant for the said purpose as well as its efficacy prompted this research. Study investigated effect of lipophilic and hydrophilic leaf extracts of Portulaca oleracea on oestrous cycle, female sex hormones at various phases of oestrous cycle and ovarian and uterine histomorphology in albino rats. Experimental procedure Experimental animals were randomly divided into 7 groups of 5 rats each. Group A (control) received 0.5 ml 20% Tween 80 (vehicle), groups B, C & D received 125, 250 & 500 mg/kg of the lipophilic extract respectively and E, F & G received 125, 250 & 500 mg/kg of the hydrophilic extract respectively for 21 days. Oestrous cycle was assessed daily. At the end, blood samples (for hormones) and ovarian &uterine sections (histoarchitecture) were collected. Results and conclusion Both extracts had no significant (p > 0.05) effect on oestrous cycle, ovarian & uterine histoarchitecture and female sex hormones except at proestrus phase where significant (p < 0.05) decrease in LH and FSH was recorded. P.oleracea as used in this study may have deleterious effect on female reproductive system as shown by the disruption of the hormones at proestrus phase. This can form a basis to refute the use of P.oleracea leaf extracts in enhancing fertility as it has been shown to affect the gonadotropins involved in folliculogenesis.

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Effects of Lipophilic and Hydrophilic leaf extracts of Portulaca oleracea Linn. (Purslane) on male reproductive parameters in albino rats

Cited by 11 publications

References 0 publications

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

Reproductive toxicity potentials of methanolic extract of Portulaca oleracea in male rats: An experimental study

Lipophilic and hydrophilic leaf extracts of Portulaca oleracea (Purslane) disrupts female sex hormones in albino rats (Rattus norvegicus)

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