Effects of lipopolysaccharide extracted from Prevotella intermedia on bone formation and on the release of osteolytic mediators by fetal mouse osteoblasts in vitro

Pelt, Paco; Zimmermann, Bernd; Ulbrich, Norbert; Bernimoulin, Jean‐Pierre

doi:10.1016/s0003-9969(02)00150-4

Cited by 47 publications

(35 citation statements)

References 41 publications

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“…Moreover, it has been shown recently that leptin, a protein mainly synthesized by adipocytes, may enhance P. intermedia LPS-induced TNF-a production by macrophages [101]. P. intermedia LPS has been shown to reduce alkaline phosphatase activity and mineralization, and to induce IL-6 and metalloproteinases in fetal mouse osteoblasts, contributing to the inhibition of bone formation and the enhancement of osteolysis [102,103]. LPS of P. nigrescens and of P. intermedia may also contribute to tissue destruction by stimulating the production of nitric oxide in host cells [103,104].…”

Section: A Weak Pathogen That Can Cause Serious Infections Virulence mentioning

confidence: 99%

“…P. intermedia LPS has been shown to reduce alkaline phosphatase activity and mineralization, and to induce IL-6 and metalloproteinases in fetal mouse osteoblasts, contributing to the inhibition of bone formation and the enhancement of osteolysis [102,103]. LPS of P. nigrescens and of P. intermedia may also contribute to tissue destruction by stimulating the production of nitric oxide in host cells [103,104]. However, a cysteine protease produced by P. intermedia may help attenuate the deleterious effects of LPS by cleaving CD14 and the LPS-binding protein [105].…”

Section: A Weak Pathogen That Can Cause Serious Infections Virulence mentioning

confidence: 99%

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New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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In light of recent studies based on cultivation-independent methods, it appears that the diversity of Prevotella in human microbiota is greater than was previously assumed from cultivation-based studies, and that the implication of these bacteria in several human diseases was unrecognized. While some Prevotella taxa were found during opportunistic infections, changes in Prevotella abundance and diversity were discovered during dysbiosis-associated diseases. As member of the microbiota, Prevotella may also be considered as a reservoir for resistance genes. Greater knowledge on Prevotella diversity, as well as new insights into its pathogenic potential and implication in dysbiosis are expected from the use of human microbe identification microarrays, from whole-genome sequence analyse, and from the NIH Human Microbiome Project data. New approaches, including molecular-based methods, could contribute to improve the diagnosis of Prevotella infections.

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Section: A Weak Pathogen That Can Cause Serious Infections Virulence mentioning

confidence: 99%

Section: A Weak Pathogen That Can Cause Serious Infections Virulence mentioning

confidence: 99%

New Insights into Prevotella Diversity and Medical Microbiology

Alauzet¹,

Marchandin

Lozniewski³

2010

Future Microbiol.

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“…Prevotella intermedia LPS exerts diverse activities and is regarded as a main virulence factor of this bacterium. It has been reported previously to reduce alkaline phosphatase activity and mineralisation and to induce nitric oxide, IL-6 and metalloproteinases in fetal mouse osteoblasts, leading to the inhibition of bone formation and enhancement of osteolysis [9]. Tannerella forsythia belongs to a group of highly proteolytic periodontopathogens, together with Porphyromonas gingivalis and Treponema denticola, the so-called 'red complex' species, and is regarded as a major aetiological contributor to adult periodontitis [10].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens

Lee

Jun

Lee

et al. 2010

International Journal of Antimicrobial Agents

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“…Proteases: Degradation of the intercellular matrix [40] P. intermedia LPS: Induction of the synthesis of pro-inflammatory cytokines by gingival epitheliocytes and periodontal ligament cells [30] 1. Enhanced expression of metalloproteinases mmp-2 and mmp-9 with osteoblasts [41] P the MFA and the neck of viruses: The HSV, the EBV, etc. Viruses can form associations with representatives of the opportunistic microflora and enhance the immune response in patients.…”

Section: Discussionmentioning

confidence: 99%

“…[40][41][42][43][44] The oral cavity and mucous membrane are the main places of the persistence of some human viruses. In particular, many herpesviruses are capable of active replication and persistence in the cells of the epithelium of the oral cavity.…”

Section: The Role Of Herpesvirus In the Pathogenesis Of Odontogenic Amentioning

confidence: 99%

Untitled

Batyrbekova¹

2017

AJP

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Pyoinflammatory diseases of maxillofacial area (MFA) are one of the most serious problems of maxillofacial surgery. The high medical and social significance of these diseases are due to their frequent occurrence in persons of working age and the risk of life-threatening complications: Bleeding from the great vessel, brain abscess, the spread of infection into the deep cellular spatium of the collum. In more than 1/3 of all patients, pyogenic lesions of MFA develop on the background of secondary immunodeficiency, accompanied by impaired regulation of the secretion of pro-inflammatory cytokines, and predisposing to prolonged smoldering flow or, on the contrary, rapid spread of inflammation with extensive tissue damage. This fact determines the importance of developing integrated approaches to diagnostics and treatment. The aim of the study is to generalize modern ideas about causative agents and their effect on the features of the inflammatory diseases of the MFA. We systematized and analyzed contemporary works of Russian and foreign authors on the study of the effects of causative agents of bacterial and viral nature and characteristic changes in the immune status. The modern data on the role of microbial factors in the development and maintenance of local and systemic immunological status disorders in case of inflammatory disease of MFA are presented, the impact on the development of bacterial and viral microflora diseases is given, with special attention paid to immunomodulatory effects of causative agents. The factors of pathogens influence most frequently associated with inflammatory diseases of theMFA and collum, as well as the relationship of individual microorganisms with the clinical manifestations of this pathology type and the detection of the pathogenetic role of immune disorders, allow to conduct studies on the formation of optimal correction schemes for each patient (personified) depending on the features of the course of the disease.

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Effects of lipopolysaccharide extracted from Prevotella intermedia on bone formation and on the release of osteolytic mediators by fetal mouse osteoblasts in vitro

Cited by 47 publications

References 41 publications

New Insights into Prevotella Diversity and Medical Microbiology

New Insights into Prevotella Diversity and Medical Microbiology

Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens

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