Effects of lithium salts on plasma protein bound iodine and uptake of I131 in thyroid gland of man and rat

Sedvall, Göran; Jonsson, B.; Pettersson, Ulla; Levin, K.

doi:10.1016/0024-3205(68)90239-7

Cited by 90 publications

(25 citation statements)

References 9 publications

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“…This is in agreement with some studies (9) but contrasts with others in which uptake was decreased (19,20) or increased (3)(4)(5). Increased iodide uptake might accompany lithium-induced goiter caused by low circulating T4 and T3 with elevated TSH (3,5,9,21,22). However, none of the present group of thyrotoxic patients became hypothyroid.…”

Section: Resultssupporting

confidence: 92%

The Use of Lithium in the Treatment of Thyrotoxicosis

Temple¹,

Berman²,

Robbins³

et al. 1972

J. Clin. Invest.

128

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A B S T R A C T Since lithium has been showx%n to inhibit release of iodine from the thyroid, we have investigated its therapeutic potential in thvrotoxicosis. Eight detailed "lI kinetic studies were performed on seven thvrotoxic women and data was analy,zed using a computer program. Lithium at serum levels of about 1 mEq 'liter decreased the loss of '31I from the thyroid, led to a fall in serum "II levels and diminished urinary "'I excretion. Coinputer simulation of the lithium effect required, in every case, that lithium inhibit hormonal and( nonllormonal thyroid iodine release. In five cases a second lithium effect was required for a satisfactory fit of the model soluton with observed data: namely, an inhibition of hormone disappearance from serunm.Neither inhibition of release nor of hormone disappearance seemled to be affected by mlethimazole (release: 52% decrease without methimilazole, 60,% \w-ith mlethimazole; hormone disappearance: -60% decrease in both). Wlheni Li' was discontinued, recovery of the iodine release rate and hormiione disappearance rate over the observed time span -was variable, ranging from no recovery to rates that exceeded pre-Li' values. When Li' is used alone its effect on serum hormone levels is diminished due to continued accumulation of iodide by the thyroid. Thus, serum thyroxine-iodine levels fell 21-30% in 6-8 days in patients wlho did not receive methimazole and 15-67%C in the methimazoletreated subjects. For prolonged therapy, therefore, a thiocarbamide drug must be used in conjunction witlh Li'. The similarity of inhibition of iodine release from the thvroid produced by Li' and iodides is discussed.

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Section: Resultssupporting

confidence: 92%

The Use of Lithium in the Treatment of Thyrotoxicosis

Temple¹,

Berman²,

Robbins³

et al. 1972

J. Clin. Invest.

128

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“…Previous observations indicated that lithium inhibits the release of radioiodine from the thyroid, thereby prolonging the biological half-life of 131 1 (Sedvall et al 1968;Berens et al 1970;Spaulding et al 1972;Turner et al 1976). Our increase in the thyroid biological half-life of 131 1 is in agreement with these findings.…”

Section: Discussionsupporting

confidence: 92%

“…In a similar study to ours Abuzzahab et al (1969) noticed an increase in uptake of 131 I in ewes following lithium treatment (serum levels O· 8-1·0 mEq L -1) for 4 months and the uptake returned to normal levels after 7 months of lithium treatment. It is possible that this normalization trend in long-term lithium-treated animals is mediated through the thyroid stimulatory hormone (TSH) as postulated by Sedvall et al (1968), who indicated that the uptake of 131 1 may be regulated by TSH. When circulating levels of triiodothyronine (T3) and thyroxine (T4) are decreased following chronic lithium treatment, the consequent rise in TSH normalizes the thyroidal uptake of 1311.…”

Section: Discussionmentioning

confidence: 99%

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Dhawan¹,

Sharma²,

Sharma³

et al. 1988

Aust. Jnl. Of Bio. Sci.

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“…Although the over-all rate of goiter formation was only 3.6%, this was higher than the endemic incidence of 1.1% (3). Sedvall, Jdnsson, Pettersson, and Levin reported increased 'I uptake and decreased serum PBI in patients on lithium therapy (4) and in normal volunteers (5). Lithium given to rats (3.0-3.75 mEq/kg per 24 hr) for 7 days also caused a decrease in PBI levels (4).…”

mentioning

confidence: 96%

Antithyroid effects of lithium

Berens¹,

Bernstein²,

Robbins³

et al. 1970

J. Clin. Invest.

166

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A B S T R A C T Lithium has been reported to be goitrogenic when used for the treatment of manic-depressive psychosis. To investigate the effects of lithium on iodine metabolism, male Sprague-Dawley rats were placed on a low iodine (LID) or normal iodine diet (NID) containing enough Li2COs to give serum lithium levels of 0.23-0.86 mEq/liter (human therapeutic range is 0.6-1.6 mEq/liter). The following effects were noted with lithium treatment: (a) thyroid weight increased concomitant with a slowing of thyroidal iodine release; (b) the ability to concentrate iodide was increased only after goiters were established; (c) on the LID, 'I uptake was elevated throughout all phases of treatment, even when the release rate was normal; (d) iodine organification was unaffected but the proportion of 'I present as iodothyronines was decreased; (e) the thyroidal 'I content was increased; (f) despite these changes, the serum PBI remained normal as did the thyroxine turnover rate; and (g) thyrotropin (TSH) levels in serum were the same as controls except for a slight elevation early in the course of treatment; TSH levels did not correlate with goitrogenesis.When LiCl was injected in large doses into intact rats (giving serum lithium levels of 3.08-3.89 mEq/liter), the iodide concentrating mechanism, 'I uptake, and 'I release rates were depressed. Similar experiments in hypophysectomized rats receiving TSH demonstrated these to be local antithyroid effects not mediated through the pituitary.The discrepancy between acute and chronic responses to lithium, and the dissociation between the inhibition of iodine release and stimulatory effects is discussed.

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Effects of lithium salts on plasma protein bound iodine and uptake of I131 in thyroid gland of man and rat

Cited by 90 publications

References 9 publications

The Use of Lithium in the Treatment of Thyrotoxicosis

The Use of Lithium in the Treatment of Thyrotoxicosis

Effect of Short-term and Long-term Lithium Treatment on Uptake and Retention of 10dine-131 in Rat Thyroid

Antithyroid effects of lithium

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