Animal handling is a growing issue of concern in many countries around the world. Developed countries in particular show keen interest in the way animals are produced for processing. In such countries, animal welfare is increasingly becoming a primary matter in the process of keeping animals either as pets or for food and at homes or on farms. Not only are they protecting the rights of these animals but compromised handling of animal has negative effects on the carcass and overall meat quality characteristics. Poor quality animal and meat will have poor processing properties, functional quality, eating quality, and more likely to be unaccepted by consumers. Lesser attention has been paid by most developing countries on this issue. By this book chapter, it is expected that developing countries also take interest in proper on-farm and pre-slaughter handling of animals due to their beneficial effect on meat and carcass qualities.