Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Abstract

The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary. The force generated by the cardiac muscle has physiologically imposed limits and depends on various characteristics such as the length, strain and the contraction velocity of the cardiomyocytes. Another characteristic is the activation time of each cardiomyocyte, which is a wave and not a static value for all cardiomyocytes. To simulate a physiologically correct excitation, the functionality of the cardiac simulation framework CardioMechanics was extended to incorporate inhomogeneous activation times. The functionality was then used to evaluate the effects of local activation times with two different tension models. The active stress generated by the cardiomyocytes was calculated by (i) an explicit function and (ii) an ode-based model. The results of the simulations showed that the maximum pressure in the left ventricle dropped by 2.3% for the DoubleHill model and by 5.3% for the Lumens model. In the right ventricle the simulations showed similar results. The maximum pressure in both the left and the right atrium increased using both models. Given that the simulation of the inhomogeneously activated cardiomyocytes increases the simulation time when used with the more precise Lumens model, the small drop in maximum pressure seems to be negligible in favor of a simpler simulation model

Electro-Mechanical Whole-Heart Digital Twins: A Fully Coupled Multi-Physics Approach

“…In this study, we present a detailed mathematical description of a fully coupled multi-scale model of the human heart building on previous work in cardiac mechanics [25,31,43,[52][53][54][55] and cardiac electrophysiology [49,[56][57][58][59][60]. We parameterize and use state-of-the-art myofilament models based on human physiology to describe membrane kinetics, excitation-contraction coupling and active tension generation in the atria and the ventricles.…”