Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats

Abstract

Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.

High Levels of Serum Prostaglandin E2 in Children with Osteogenesis Imperfecta Are Reduced by Neridronate Treatment

“…In vitro and in vivo studies have demonstrated that various bb modulate the release of proinflammatory mediators (9,10) and inhibit PGE 2 synthesis induced by phlogistic or mechanical stimuli (13,18,19). These studies postulate that the inhibition of endogenous PGE 2 production may be involved in the mechanism of action of bb (20).…”

“…Prostaglandins are an important part of this mechano-biochemical signalling (15)(16)(17). Stress-induced PGE 2 release has been well-investigated in vitro study, suggesting an activation mediated by the inducible COX-2-catalyzed pathway (18). It is well known that in OI, the genetic defect in the osteoblast interferes with the multiple mechanisms that normally ensure adaptation of the skeleton to the increasing mechanical need during growth (7).…”

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

“…[1][2][3] Bisphosphonates have been the most common prescribed medications for osteoporotic patients [4][5][6] and their effects on orthodontic tooth movement have been investigated in rat model. [7][8][9][10] Essentially, bisphosphonates are internalized into osteoclasts leading to inhibition of bone resorption and induction of osteoclast apoptosis. [11][12][13] ZOL is a potent and novel bisphosphonate that has been recently shown to significantly reduce fracture risk in the patients who received once-yearly dosing regimen for the treatment of postmenopausal osteoporosis.…”

The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model

“…Borah et al 5 evaluated changes in bone mineralization and architecture in postmenopausal women with osteoporosis after long-term treatment with risedronate, elucidating normalization of mineral levels. The effect of bisphosphonates on orthodontic tooth movement (OTM) has also been investigated in some reports, [6][7][8][9][10] in which administration of bisphosphonates decreased OTM.…”