Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats

Nunes, Nara L.T.; Messora, Michel Reis; Oliveira, Luana Farias de; Lisboa, Mário Roberto Pontes; Garcia, Marina Costa Barcellos; Rêgo, Rodrigo Otávio; Novaes, Arthur B.; Souza, Sérgio Luı́s Scombatti de; Ervolino, Edílson; Furlaneto, Flávia Aparecida Chaves

doi:10.1902/jop.2017.170228

Cited by 6 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The X-ray generator was operated at 50 kV with a source current of 500 µA and a 0.5 mm aluminum filter. A volume of interest from the apexes of all roots of the mandibular first molar (M1) up to the roof of the furcation of M1, touching the roots surfaces (CT-Analyzer; Bruker, Belgium) was selected for bone volume measurement, as previously described 37,38 . The bone volume/tissue volume (BV/TV), porosity, trabecular number (Tb.N) and trabecular separation (Tb.Sp) were analyzed in the volume of interested area with CtAn (Bruker, Belgium).…”

Section: Assessment Of the Hemodynamic Parameters And Electrical Stimmentioning

confidence: 99%

Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis

Ribeiro

Brognara

Silva

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Baroreceptor and chemoreceptor reflexes modulate inflammatory responses. However, whether these reflexes attenuate periodontal diseases has been poorly examined. Thus, the present study determined the effects of electrical activation of the carotid sinus nerve (CSN) in rats with periodontitis. We hypothesized that activation of the baro and chemoreflexes attenuates alveolar bone loss and the associated inflammatory processes. Electrodes were implanted around the CSN, and bilateral ligation of the first mandibular molar was performed to, respectively, stimulate the CNS and induce periodontitis. The CSN was stimulated daily for 10 min, during nine days, in unanesthetized animals. On the eighth day, a catheter was inserted into the left femoral artery and, in the next day, the arterial pressure was recorded. Effectiveness of the CNS electrical stimulation was confirmed by hypotensive responses, which was followed by the collection of a blood sample, gingival tissue, and jaw. Long-term (9 days) electrical stimulation of the CSN attenuated bone loss and the histological damage around the first molar. In addition, the CSN stimulation also reduced the gingival and plasma pro-inflammatory cytokines induced by periodontitis. Thus, CSN stimulation has a protective effect on the development of periodontal disease mitigating alveolar bone loss and inflammatory processes.

show abstract

Section: Assessment Of the Hemodynamic Parameters And Electrical Stimmentioning

confidence: 99%

Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis

Ribeiro

Brognara

Silva

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Administration of cannabinoid‐2 receptor agonist Hu‐308 into the gingival tissue or interdental space of rats prevented bone resorption and decreased the gingival production of inflammatory mediators in rats with LPS‐induced periodontitis . Application of tiludronic acid into the gingival tissue promoted a protective effect against tissue destruction in EP of diabetic rats . Our study similarly followed the protocol as in these studies, and presented the advantage of avoiding possible systemic adverse effects of rhPGRN.…”

Section: Discussionmentioning

confidence: 54%

“…Local application of anti-inflammatory agents has been employed in some periodontitis model studies. [39][40][41] Administration of cannabinoid-2 receptor agonist Hu-308 into the gingival tissue or interdental space of rats prevented bone resorption and decreased the gingival production of inflammatory mediators in rats with LPS-induced periodontitis. 40 Application of tiludronic acid into the gingival tissue promoted a protective effect against tissue destruction in EP of diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…40 Application of tiludronic acid into the gingival tissue promoted a protective effect against tissue destruction in EP of diabetic rats. 41 Our study similarly followed the protocol as in these studies, and presented the advantage of avoiding possible systemic adverse effects of rhPGRN. So far, the effects of local administration of rhPGRN on inflammatory disease model are rarely studied.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Progranulin is highly expressed in patients with chronic periodontitis and protects against experimental periodontitis in rats

Xiao

Zuo

Chen

et al. 2018

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…Material and methods. The rat models, used in the reviewed publications were: ligature-induced [5,13,[15][16][17][18][19], streptozotocin-induced [2,3,20,21] and immune complexes-induced [22] experimental periodontitis; 3-wall periodontal defect in Wistar rats [9,14],osteoporotic rats periodontal fenestration defect model [4], apical periodontitis, induced in Wistar rats by pulp exposure to oral cavity [23], altered functional loading model with use of a hard and soft diet and the posterior bite-blocks in rats [24], as well as rats stress exposures in different modes [25], experimental rat model of surgically created chronic acid reflux esophagitis [26]. The combined bilayered compartmentalized system was used to promote the regeneration of alveolar bone in Wistar rats [14].…”

mentioning

confidence: 99%

Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches

Kordiyak¹

2020

Ukr. ž. med. bìol. sportu

View full text Add to dashboard Cite

Chronic periodontitis is a common dental disease, resulting in destruction of gingival tissue, periodontal ligament, cementum, alveolar bone and, consequently- teeth loss in the adult population. Experimental animal models have enabled the study of periodontal disease pathogenesis and are used to test new therapeutic approaches for treating the disease The purpose of this review study was to draw the evidence from animal models, required for future assessment of destructional and regenerative processes in periodontal tissues. Material and methods: a rat experimental periodontitis models of ligature, streptozotocin, and immune complexes induced periodontitis, periodontal defect, altered functional loading, stress exposures and surgically created chronic acid reflux esophagitis models. Histomorphomorphological/-metrical, immunohisto (-cyto)chemical and histopathological analysis, micro-computed tomography, scanning and transmission electron microscopy, polarizing light and confocal microscopy, spectrophotometry, radiographic and biomechanical analysis, descriptive histology and computer-assisted image analysis. Results and discussion. Scaling and root planing may not always be effective in preventing periodontal disease progression, and, moreover, with currently available therapies, full regeneration of lost periodontal tissues after periodontitis cannot be achieved. However, in 70.5% of the results of experimental studies reported, irrespective of the defect type and animal model used, beneficial outcome for periodontal regeneration after periodontal ligament stem cell implantation, including new bone, new cementum and new connective tissue formation, was recorded. Therefore, platelet-rich fibrin combined with rat periodontal ligament stem cells provides a useful instrument for periodontal tissue engineering. Conclusion. There is sufficient evidence from preclinical animal studies suggesting that periodontal tissue engineering would provide a valuable tool for periodontal regeneration. Further elaboration of the developed in preclinical studies experimental techniques should justify progress to clinical studies and subsequent medical application

show abstract

Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats

Abstract: Local administration of TIL promoted a protective effect against tissue destruction in EP in diabetic rats, and the dosage of 3 mg/kg of TIL promoted the best results regarding its antiresorptive and anti-inflammatory effects.

Cited by 6 publications

References 49 publications

Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis

Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis

Progranulin is highly expressed in patients with chronic periodontitis and protects against experimental periodontitis in rats

Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches

Contact Info

Product

Resources

About