Effects of local anaesthetics on responses of human saphenous vein and bovine coronary artery to neurotransmitters, acetylcholine, noradrenaline and 5-hydroxytryptamine

Wali, F. A.

doi:10.1016/0306-3623(86)90182-5

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…In agreement with previous reports, 10,11,13 lower concentrations of local anesthetics produced vasoconstriction followed by vasodilation at 3 ϫ 10 Ϫ4 M levobupivacaine, 10 Ϫ3 M ropivacaine, and 10 Ϫ2 M mepivacaine, which correspond to toxic plasma concentrations. 8,9,14 The effects of local anesthetics on the peripheral vasculature are not uniform and may depend on the method of administration (i.e., intravenous, intraarterial, or local), concentration, target organ, and isomer.…”

Section: Discussionsupporting

confidence: 93%

Lipid Emulsion Reverses Levobupivacaine-induced Responses in Isolated Rat Aortic Vessels

Sohn

Baik

et al. 2011

Anesthesiology

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Section: Discussionsupporting

confidence: 93%

Lipid Emulsion Reverses Levobupivacaine-induced Responses in Isolated Rat Aortic Vessels

Sohn

Baik

et al. 2011

Anesthesiology

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“…The VAR is mediated through a local mechanism (1,5,8,37), and the central nervous system is not necessary to evoke the response (20,25). This construct is supported by the observations that the VAR persists during acute spinal and sympathetic neural blockade proximal to the site of measurement (14,15,19,20,31,36), in denervated skin flaps (39) and in areas distal to the lesion in spinal cord transection patients (2,33,35).…”

Section: Discussionmentioning

confidence: 64%

“…To accomplish this objective, we compared changes in forearm and calf skin blood flow (SkBF) during cuff inflation and limb dependency at the sites where the VAR was blocked by local anesthesia (1,5,14,15,19,20,32,36,37) and at unblocked sites.…”

mentioning

confidence: 99%

Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure

Okazaki

Fu²,

Martini

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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We dissected the relative contribution of arteriovenous hemodynamics, the venoarteriolar response (VAR), and the myogenic reflex toward a decrease in local blood flow induced by venous congestion. Skin blood flow (SkBF) was measured in 12 supine subjects via laser-Doppler flowmetry 1) over areas of forearm and calf skin, in which the VAR was blocked by using eutectic mixture of local anesthetics (EMLA sites) and 2) over the contralateral forearm or calf skin (control sites), using two different techniques: limb dependency of 23-37 cm below the heart and cuff inflation to 40 mmHg. During limb dependency, SkBF decreased at the control sites, whereas it remained unchanged at the EMLA sites. In contrast, during cuff inflation, SkBF decreased at the control sites and also decreased at the EMLA sites. The percent change in SkBF from baseline was greater during cuff inflation than limb dependency at both the control sites and the EMLA sites. Estimated skin vascular resistance remained unchanged at the EMLA sites during cuff inflation, as well as limb dependency. Thus the decrease in SkBF during venous congestion with cuff inflation is not solely due to the cutaneous VAR but also to a reduction in local perfusion pressure. The VAR is therefore most specifically quantified by venous congestion induced by limb dependency, rather than cuff inflation. Finally, from both techniques, we calculated that during venous congestion induced by limb dependency (calf), approximately 45% of the nonbaroreflex vasoconstriction is induced by the VAR and approximately 55% by the myogenic reflex.

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“…These reductions in ext-PmO 2 , which were not observed in previous studies (10,11) where Pri-Fely was administered intravenously, 3 were shorter than those of int-PmO 2 . Since prilocaine has been reported to constrict the coronary arteries at a dose larger than that used clinically (14), the reduction in ext-PmO 2 may have been caused by constriction of the coronary arteries as a result of the administration of prilocaine. Nevertheless, prolonged CBF reduction may decrease ext-PmO 2 as well as int-PmO 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Another possibility was the vasoconstrictive effect of prilocaine. Since prilocaine has been reported to constrict the coronary arteries at a dose larger than that used clinically (14), the reduction in ext-PmO 2 may have been caused by constriction of the coronary arteries as a result of the administration of prilocaine.…”

Section: Discussionmentioning

confidence: 99%

Effects of local injection of prilocaine–felypressin on the myocardial oxygen balance in dogs

Miyachi¹,

Ichinohe²,

Kaneko³

2003

European J Oral Sciences

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The authors investigated the effects of felypressin (Fely), a non-adrenergic vasoconstrictor, used together with prilocaine on myocardial oxygen balance. Six open-chest dogs were studied under urethane and alpha-chloralose anesthesia. Systolic arterial pressure, diastolic arterial pressure, mean pulmonary arterial pressure and pulmonary capillary wedge pressure, heart rate, coronary blood flow (CBF), internal and external myocardial oxygen tension (int- or ext-PmO2), and cardiac output were observed. Three doses of Citanest-Octapressin, which contains 3% prilocaine and 0.03 IU ml(-1) Fely (Pri-Fely) - 0.09, 0.18, and 0.3 ml kg(-1)- were injected into the tongue. Observations were performed up to 60 min after the injection. The CBF and int-PmO2 was reduced following the injection of each of the three doses of Pri-Fely. There were negative correlations between the Pri-Fely dose per body weight and the maximum reductions in CBF (r = -0.52, P < 0.05), in int-PmO2 (r = -0.78, P < 0.05), and in ext-PmO2 (r = -0.55, P < 0.05), respectively [corrected]. These results suggest that an administration of Fely at doses more than 2.7-5.4 mIU kg(-1) (3-6 cartridges of Pri-Fely) may induce an imbalance between the oxygen supply and demand in myocardial tissues of patients with cardiovascular diseases.

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Effects of local anaesthetics on responses of human saphenous vein and bovine coronary artery to neurotransmitters, acetylcholine, noradrenaline and 5-hydroxytryptamine

Cited by 13 publications

References 23 publications

Lipid Emulsion Reverses Levobupivacaine-induced Responses in Isolated Rat Aortic Vessels

Lipid Emulsion Reverses Levobupivacaine-induced Responses in Isolated Rat Aortic Vessels

Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure

Effects of local injection of prilocaine–felypressin on the myocardial oxygen balance in dogs

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