Effects of Local and Whole Body Hyperthermia on Immunity

Baronzio, Gian Franco; Seta, Roberta Delia; D’Amico, Mario; Baronzio, Attilio; Freitas, Isabel; Forzenigo, Giorgio; Gramaglia, Alberto; Hager, E. Dieter

doi:10.1007/978-0-387-33441-7_20

Cited by 19 publications

(21 citation statements)

References 164 publications

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“…Although eosinophilia among TB patients negatively correlates with fever as a symptom [23], we have not found a report on the variation of the AEC with temperature as observed in our study. Our study finding is expected because TB patients have a predominant Th1 immune response against Mtb that is characterised by pyrogenic cytokines as opposed to a Th2 response that engenders eosinophilia [24, 25]. Conversely, Boneberg and Hartung (2003) demonstrated a 3‐fold rise in Th2 cytokines and a 15% reduction in Th1 cytokines at high temperatures (40 °C) using staphylococcal antigens [26].…”

Section: Discussionmentioning

confidence: 85%

Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients

Baluku

Anguzu

Bongomin

et al. 2020

Tropical Med Int Health

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Objective To determine clinical correlates of the peripheral absolute eosinophil count (AEC) among bacteriologically confirmed TB patients in Uganda. Materials and Methods We evaluated data of bacteriologically confirmed adult TB patients who had a peripheral blood AEC measurement at the National TB Treatment Center in Uganda during a cross‐sectional study. We performed linear regression analysis for correlates of log‐transformed AEC. Results We included 235 patients in this analysis with a median (interquartile range, IQR) age of 31 (24–39) years. 60.4% were male, and 33.6% had TB/HIV co‐infection. In a multivariable linear regression model that controlled for age, residence type, HIV status, weight loss, anorexia, body mass index, CD8+ T‐cell count, haemoglobin level and TB bacillary load, males had a 47.0% higher AEC than females (adjusted coefficient (R2) = 0.385, 95% confidence interval (CI) 0.012–0.759 P = 0.043). Also, a 1 °C raise in temperature resulted in an 11.5% decrease in the AEC (R2 = −0.122 95% CI (−0.233 to −0.011) P = 0.031) while a 1 cell/mm3 increase in the CD4+ T‐cell count resulted in a 0.10% increase in the AEC (R2 = 0.001 95% CI (0.000–0.001) P = 0.032). Conclusion The AEC was higher among males than females, consistent with the normal population distribution of AEC among Ugandans. The AEC was weakly but positively correlated with the CD4 count and negatively correlated with temperature.

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Section: Discussionmentioning

confidence: 85%

Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients

Baluku

Anguzu

Bongomin

et al. 2020

Tropical Med Int Health

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“…6,7 It has also been shown that this type of hyperthermia affects the production and secretion of cytokines. 8 Other researchers have shown that the combination of curcumin and hyperthermia has a beneficial anti-cancer effect and indicated that combination therapy significantly inhibited cell proliferation of MS-1 and LL/2 in vitro. It has also been shown that the combination therapy conducted in this way inhibited tumor growth and lengthened life expectancy.…”

Section: Discussionmentioning

confidence: 99%

Influence of temperature rise by 2.5°C on the increase of apoptosis of HL-60 cells treated with busulfan

Sztafrowski¹,

Jaźwiec²,

Kuliczkowski³

2019

Adv Clin Exp Med

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Background. Hyperthermia is one of the new and still poorly known methods used in cancer treatment. It consists of raising the patient's body temperature for therapeutic purposes. The article presents the results of in vitro studies describing the effect of an elevated temperature of 39.5°C, the busulfan cytostatic and their combination on the level of apoptosis of human leukemia HL-60 cells. Objectives. During the experiments, the influence of a 2.5°C temperature increase on the behavior of the population of 2 groups of HL-60 cells, with busulfan cytostatic and without the cytostatic, was investigated. The control group consisted of 2 groups of HL-60 cells incubated at 37.0°C with the cytostatic and without the cytostatic. Two questions were asked: 1. Is low-temperature hyperthermia likely to have an effect on the effectiveness of busulfan cytostatic? 2. Does the increase in temperature by 2.5°C have an effect on the level of apoptosis in the unsaturated HL-60 cell line? Material and methods. Human promyelocytic leukemia cell line HL-60 was used in the experiments to examine the influence of temperature on apoptosis HL-60 in 2 separated incubators set to 37.0°C and 39.5°C for 3 h. Apoptosis was assessed with flow cytometry using Annexin V. Results. An increase in mortality of HL-60 cells was found in the case of simultaneous exposure to elevated temperature and busulfan in comparison to the group of cells treated with the cytostatic alone. There was no observed effect of an elevated temperature of 39.5°C alone on the level of HL-60 cell apoptosis. Conclusions. Analysis of the study results indicates that low-temperature hyperthermia may be used to increase the effectiveness of busulfan treatment. No effect of an elevated temperature of 39.5°C on the level of apoptosis in HL-60 cells that were not treated with busulfan was observed. There is a need to test the efficacy of other cytostatic agents at elevated temperatures.

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“…The challenge is how to manage the immune response [74], when we know that the general immune system is not able to recognise the tumour. The key for the liberated tumour antigens to become the core information for antigen-presenting cells [75]. The method of mEHT acts in an integrative way compared to other hyperthermia methods [76].…”

Section: Local Tumour Destruction or Systemic Action Against Malignancy?mentioning

confidence: 99%

Heating Preciosity—Trends in Modern Oncological Hyperthermia

Szász¹,

Szász²,

Minnaar³

et al. 2017

OJBIPHY

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The use of hyperthermia as a treatment in oncology is a common topic for debate. Some researchers expect a breakthrough in oncological treatments with hyperthermia, whereas others have disregarded the method. Serious questions concerning hyperthermia have arisen. Should homogeneous (isothermal) or heterogeneous (selective) heating being used? When we use selective heating (heterogeneity), should the entire tumour be targeted or should the malignant cells be individually selected? Does the mechanism involve thermal cell death or thermally-assisted cell death? Is the goal necrosis or apoptosis? Is hyperthermia safe as a monotherapy or does it have to be combined with conventional treatments? When the selection is local, how do we act on disseminated cells that represent a high risk of life threatening metastases? When local heating is the focus, how should it be carried out with measured and controlled? Our objective is to show how precise, selective heat transfer is necessary to remove malignant cells and, consequently, how hyperthermia as part of the immune-oncology can change the game in this promising field of oncological therapies.

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Effects of Local and Whole Body Hyperthermia on Immunity

Cited by 19 publications

References 164 publications

Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients

Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients

Influence of temperature rise by 2.5°C on the increase of apoptosis of HL-60 cells treated with busulfan

Heating Preciosity—Trends in Modern Oncological Hyperthermia

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