Effects of Local Irradiation (Co60 Teletherapy) on the Peripheral Blood and Bone Marrow

Goswitz, F.A.; Andrews, Gould A.; Kniseley, Ralph M.

doi:10.1182/blood.v21.5.605.605

Cited by 67 publications

(5 citation statements)

References 19 publications

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“…It is an accepted fact that the hemopoietic system is sensitive to radiation. A pronounced and persistently hypoplastic marrow is produced in the locally irradiated site (6). Also, there is a reduction in the leukocytes and lymphocytes with generally a small amount of change in the red cell and platelet values in the peripheral blood after local irradiation (6).…”

Section: Discussionmentioning

confidence: 99%

“…A pronounced and persistently hypoplastic marrow is produced in the locally irradiated site (6). Also, there is a reduction in the leukocytes and lymphocytes with generally a small amount of change in the red cell and platelet values in the peripheral blood after local irradiation (6). The possible explanation for the observed leucopenia is that during a course of fractionated radiotherapy, a large number of circulating stem cells enter the irradiated site and are destroyed, creating a leukocyte depression (7).…”

Section: Discussionmentioning

confidence: 99%

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"Routine" Weekly Blood Counts During Breast Irradiation for Early Stage Cancer: Are They Really Necessary?

Ampil

Burton

2001

Breast Journal

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The present investigation analyzed the weekly blood count assays of 73 women receiving breast irradiation after organ-preserving surgery for early stage cancer. With regard to leucopenia and anemia, grade 1 toxicity occurred in 26% and 21%, respectively, of the cases. Thrombocytopenia of any degree and grades 2-4 leucopenia or anemia were either not seen or were minimally observed. Most of the patients who experienced grade 1 or grade 2 toxicity had received preirradiation chemotherapy. We stress the importance of a baseline blood count recording prior to breast irradiation and the need for further study to define better the population for whom continuous weekly blood count determinations might prove to be useful.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

"Routine" Weekly Blood Counts During Breast Irradiation for Early Stage Cancer: Are They Really Necessary?

Ampil

Burton

2001

Breast Journal

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“…Total body irradiation has been linked to bone marrow suppression [ 71 , 72 ], spurring the development of focal RT regimens to reduce hematologic toxicity [ 73 ]. Focal irradiation with limited bone marrow involvement appears to have mild effects on circulating white blood cells, and local areas of bone marrow injury can regenerate with time [ 74 , 75 ]. Local RT has also been shown to recruit bone marrow precursors to the irradiated site [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models

Yu,

Gadwa,

Ross

et al. 2024

Cancer Immunol Immunother

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Clinically approved head and neck squamous cell carcinoma (HNSCC) immunotherapies manipulate the immune checkpoint blockade (ICB) axis but have had limited success outside of recurrent/metastatic disease. Interleukin-7 (IL7) has been shown to be essential for effector T-cell survival, activation, and proliferation. Here, we show that IL7 in combination with radiotherapy (RT) is effective in activating CD8 + T-cells for reducing tumor growth. Our studies were conducted using both human papillomavirus related and unrelated orthotopic HNSCC murine models. Immune populations from the tumor, draining lymph nodes, and blood were compared between treatment groups and controls using flow cytometry, proteomics, immunofluorescence staining, and RNA sequencing. Treatment with RT and IL7 (RT + IL7) resulted in significant tumor growth reduction, high CD8 T-cell tumor infiltration, and increased proliferation of T-cell progenitors in the bone marrow. IL7 also expanded a memory-like subpopulation of CD8 T-cells. These results indicate that IL7 in combination with RT can serve as an effective immunotherapy strategy outside of the conventional ICB axis to drive the antitumor activity of CD8 T-cells.

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“…Several studies have shown that external beam RT for tumors of various primary sites is associated with a 24–37% decrease in WBC counts by the end of treatment [4, 5, 7, 8, 23–25]. Baseline WBC counts have been found to be highly predictive of leukopenia during RT for various solid malignancies [3, 8, 9].…”

Section: Discussionmentioning

confidence: 99%

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study

et al. 2019

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BackgroundTo compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy.MethodsWeekly blood test results were extracted from the charts of patients treated within a phase III study comparing HYPO to CF. In order to compare WBC counts at the same nominal dose in both arms and thus to tease out the effect of fractionation, for each recorded WBC value the corresponding cumulative total dose was extracted as well. WBC counts were binned according to percentiles of the delivered dose and three dose levels were identified at median doses of 16, 34.1 and 52 Gy, respectively. A General Linear Model based on mixed design Analysis Of Variance (ANOVA) was used to test variation of WBC counts between the two treatment arms.ResultsOut of 168 randomized patients, 140 (83.3%) had at least one observation for each one of the selected dose levels and were included in the analysis. Mean counts were lower in the CF than the HYPO arm at all selected dose levels, reaching a statistically significant difference at dose level #3 (5397/mm3 vs 6038/mm3 for CF and HYPO, respectively, p = 0.004). The GLM model confirms that the impact of dose on WBC counts is significantly lower in the HYPO arm over the CF one (Greenhouse-Geisser test, p = 0.04). Interestingly, while WBC counts tend to drop throughout all dose levels in the CF arm, this is the case only in the earlier part of treatment in the HYPO arm.ConclusionThis secondary analysis of a phase III study shows that dose fractionation is correlated to WBC drop during treatment of localized prostate cancer, favoring HYPO over CF.Electronic supplementary materialThe online version of this article (10.1186/s13014-019-1223-2) contains supplementary material, which is available to authorized users.

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Effects of Local Irradiation (Co60 Teletherapy) on the Peripheral Blood and Bone Marrow

Cited by 67 publications

References 19 publications

"Routine" Weekly Blood Counts During Breast Irradiation for Early Stage Cancer: Are They Really Necessary?

"Routine" Weekly Blood Counts During Breast Irradiation for Early Stage Cancer: Are They Really Necessary?

IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models

Leukotoxicity after moderately Hypofractionated radiotherapy versus conventionally fractionated dose escalated radiotherapy for localized prostate Cancer: a secondary analysis from a randomized study

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