Effects of Local Melatonin Application on Implant Osseointegration

Tresguerres, Isabel F; Clemente, C.; Blanco, Luis; Khraisat, Ameen; Tamimi, Faleh; Tresguerres, Jesús A.F.

doi:10.1111/j.1708-8208.2010.00271.x

Cited by 44 publications

(72 citation statements)

References 21 publications

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“…The histopathologic and histomorphometrical analyses for the BIC were performed with an image analyzer (Olympus). The BIC was defined directly from the bone connection with the implant perimeter13. The BIC was measured as the bone implant contact in the cortical and trabecular bone layers following a reported method13.…”

Section: Methodsmentioning

confidence: 99%

The effects of high-fat diet on implant osseointegration: an experimental study

Dündar

Yaman

Ozupek

et al. 2016

J Korean Assoc Oral Maxillofac Surg

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ObjectivesIn this study, we investigated whether a high-fat diet (HFD) affected the bone implant connection (BIC) in peri-implant bone.Materials and MethodsFour male rabbits were used in this study. Dental implant surgery was introduced into each tibia, and four implants were integrated into each animal. In both the normal diet (ND) group (n=2) and HFD group (n=2), 8 implants were integrated, for a total of 16 integrated implants. The animals continued with their respective diets for 12 weeks post-surgery. Afterward, the rabbits were sacrificed, and the BIC was assessed histomorphometrically.ResultsHistologic and histomorphometric analyses demonstrated that BIC was not impaired in the HFD group compared to the ND group.ConclusionWithin the limitations of this study, we found that HFD did not decrease the BIC in rabbit tibias.

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Section: Methodsmentioning

confidence: 99%

The effects of high-fat diet on implant osseointegration: an experimental study

Dündar

Yaman

Ozupek

et al. 2016

J Korean Assoc Oral Maxillofac Surg

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“…It has been demonstrated that the utilization of these factors improves osseous healing in animal models. 5,7 Their good performance in osseointegration in unloaded implants has been reported. 16 Implants used in other studies were either in the form of sheets or root-form implants of experimental sizes.…”

Section: Discussionmentioning

confidence: 97%

“…Four international units of recombinant human GH in the form of lyophilized powder was used locally in this study and applied as 1 shot around the implant side as stated previously by Tresguerres et al 7,14,15 in 3 different studies. Recombinant human GH is therapeutically equivalent to pituitaryderived human GH in clinical testing.…”

Section: Discussionmentioning

confidence: 99%

“…Also, trichrome stain was used to evaluate bone formation. 7,18 The results of this study were taken from control and study groups at weeks 2, 6, and 12 after implant placement.…”

Section: Discussionmentioning

confidence: 99%

“…4 In recent years, several substances have been used to improve periimplant bone response: bone morphogenetic proteins, growth factors, and more recently hormones, such as growth hormone (GH). [5][6][7] GH is able to stimulate bone growth in a dose-dependent way by direct stimulation of the epiphyseal chondrocytes. It stimulates the proliferation and differentiation of chondroprogenitor cells.…”

mentioning

confidence: 99%

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Histological Evaluation of the Effect of Using Growth Hormone Around Immediate Dental Implants in Fresh Extraction Sockets: An Experimental Study

Eldein¹,

Elghamrawy²,

Osman³

et al. 2011

Implant Dentistry

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Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial

Gonde

Rathod

Kolte

2022

Journal of Periodontology

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Background The present study aims to evaluate and compare the efficacy of locally delivered 1% melatonin gel as an adjunct to non‐surgical periodontal therapy (NSPT) in treatment of intrabony defect in Stage III periodontitis, clinically, and radiographically using cone‐beam computed tomography (CBCT). Methods This split‐mouth clinical trial randomly allotted 44 bilateral intrabony defect (in 22 patients) into two groups where Group I was treated with NSPT with locally delivered placebo gel while Group II was treated with NSPT with 1% melatonin gel. The intrabony defect fill measured from cemento‐enamel junction (CEJ)‐base of the defect (BD), and the difference in the measurement values of CEJ‒BD from baseline to 6 months denoting the bone fill and bone volume evaluated at 6 months using CBCT were the primary outcome measures. Secondary outcome measures were change in probing depth (PD), clinical attachment level (CAL), plaque index, and modified sulcus bleeding index recorded at baseline, 3 months, and 6 months. Results Both the study groups showed improvements in assessed parameters, however, a significant gain in intrabony defect fill was observed in Group II (1.46 ± 0.58) as compared with Group I (0.50 ± 0.38) and change in bone volume for Group I was 21.4645 ± 8.8980 mm3 and for Group II was 51.8418 ± 30.2329 mm3 with P < 0.0001.The mean reduction in PD and gain in CAL was 3.90 ± 0.78 and 2.94 ± 0.80 in Group II and in Group I it was 3.23 ± 0.90 and 1.96 ± 0.80 (P < 0.0001). Conclusion The use of 1% melatonin gel as an adjunct to NSPT is more beneficial in achieving better clinical and radiographic outcome at 6 months which indicates that adjunct use of melatonin gel to NSPT as a local drug delivery is preferred when compared with NSPT and placebo gel alone.

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Effects of Local Melatonin Application on Implant Osseointegration

Abstract: Within the limitation of this animal study, local melatonin application at the time of implant placement might induce more trabecular bone at implant contact and higher trabecular area density.

Cited by 44 publications

References 21 publications

The effects of high-fat diet on implant osseointegration: an experimental study

The effects of high-fat diet on implant osseointegration: an experimental study

Histological Evaluation of the Effect of Using Growth Hormone Around Immediate Dental Implants in Fresh Extraction Sockets: An Experimental Study

Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial

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