Effects of Localized Radiotherapy upon the Cellular Immune Response

Radiobiological Basis for Cancer Therapy by Total or Half-Body Irradiation

“…In any case, the cell-killing effect is not observed following 10 cGy of TBI alone, as mentioned earlier, indicating that the enhancing effect caused by TBI may be due to some change in the host's radiosensitivities. Gerber et al reported that an exposure dose of 15 cGy or more to the spleen of tumor-bearing mice brought about a decrease in the activity of killer T cells, but in a dose range between 5 and 12 cGy the activity of killer T cells was increased (Gerber et al, 1981a, Gerber et al, 1981. These results suggest that opposite effects are caused by small differences in dose to the spleen.…”

“…Gerber et al reported that an exposure dose of 15 cGy or more to the spleen of tumor-bearing mice brought about a decrease in the activity of killer T cells, but in a dose range between 5 and 12 cGy the activity of killer T cells was increased (Gerber et al , 1981a, Gerber et al , 1981). These results suggest that opposite effects are caused by small differences in dose to the spleen.…”

Selection of optimal therapy for neuroblastoma: A Study of the Immunomodulatory Effects of Surgery and Irradiation in the Murine C1300 Neuroblastoma Model

“…The effects of radiation localized to nonlymphoid tissue have not been as well explored. However, measurements of radiation scatter to the mouse spleen from single limb irradiation in an experimental model similar to ours [38] indicate that our own model may well involve splenic radiation in excess of the amount required to abrogate the function of suppressor T cells.…”