Effects of long-term ad libitum feeding on plasma lipid components and blood glucose, β-hydroxybutyrate and insulin concentrations in lean adult sheep

Vandermeerschen‐Doize, Françoise; Bouchat, J. Cl.; Bouckoms-Vandermeir, Marie-Antoinette; Paquay, R.

doi:10.1051/rnd:19830105

Cited by 17 publications

(4 citation statements)

References 6 publications

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“…Beta-hydroxybutyrate is usually present when glucose does not meet the energy requirements of the animal. For example, β-OH concentrations are more likely to increase in animals that are experiencing starvation (Leng and Annison, 1964;Vandermeerschen-Doise et al, 1983). In this study, it is likely that the energy requirements of the sheep during the 90-min transport events were met and therefore it is not unexpected that there was no change in β-OH concentration.…”

Section: Discussionmentioning

confidence: 74%

Qualitative behavioral assessment of transport-naïve and transport-habituated sheep

Wickham

Collins

Barnes

et al. 2012

Journal of Animal Science

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Section: Discussionmentioning

confidence: 74%

Qualitative behavioral assessment of transport-naïve and transport-habituated sheep

Wickham

Collins

Barnes

et al. 2012

Journal of Animal Science

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“…Following the initial decrease in circulating plasma ketone bodies in the Re‐Fed ewes, a significant increase occurred that was not seen over the same timeframe in Restricted and Fed ewes. This postprandial rise in circulating ketone body concentrations is typical of sheep adjusting to a higher plane of nutrition (51). In ruminants, when food intake increases, there are more carbohydrate fuels available for ruminal bacteria to digest.…”

Section: Discussionmentioning

confidence: 99%

Changes in Insulin, Glucose and Ketone Bodies, But Not Leptin or Body Fat Content Precede Restoration of Luteinising Hormone Secretion in Ewes

Szymanski

Schneider

Friedman

et al. 2007

J Neuroendocrinology

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The reproductive system, including pulsatile luteinising hormone (LH) secretion, is inhibited by deficits in energy availability and restored by energy surfeits. Plasma LH, insulin, leptin, ghrelin, glucose, ketone body, and nonesterified fatty acid concentrations were measured in ovariectomised, food-restricted ewes before and after return to ad libitum feeding to determine the factors that change in time to account for the restoration of pulsatile LH secretion. At 07.00 h, blood was sampled every 10 min for 5 h from ovariectomised, hypogonadotrophic, chronically food-restricted and ad libitum-fed ewes (Fed). At 12.00 h, four of the food-restricted sheep were given ad libitum access to food (Re-Fed), while three ewes continued to be food restricted (Restricted). Sampling continued for 5 h and resumed again on the mornings of days 2, 4, and 9. A pulse of LH was seen within 1 h of re-feeding in all Re-Fed ewes, and interpulse interval (IPI) was significantly shorter in Re-Fed compared to Restricted ewes and longer than in Fed ewes during the period after re-feeding. Re-Fed LH IPI was not restored to that of Fed ewes until sometime between days 4 and 9. The first pulse occurred within minutes, whereas restoration of IPI occurred after 4-8 days. Prior to the initial LH pulses seen in Re-Fed ewes, plasma ketone bodies first fell and then rose to levels significantly above those in Restricted ewes. Significant changes in circulating insulin, ghrelin, glucose, and total ketone body concentrations, daily food intake and lean body mass preceded restoration of Re-Fed LH IPI some time between days 4 and 9, but there were no significant changes in adiposity or circulating leptin concentrations, consistent with the hypothesis that LH pulses are reinitiated by changes in the availability of oxidisable metabolic fuels and possibly insulin, but not leptin concentrations.

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“…Values are expressed as means ± SEM. long-term dietary intake and weight regulation in ruminants [19,24]. In dairy cows, long-term infusion of insulin for hyperinsulinemic-euglycemic clamp techniques generally depresses dietary intake [2].…”

Section: Discussionmentioning

confidence: 99%

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

Lee

Kida

Miura

et al. 2012

The Journal of Veterinary Medical Science

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AbSTRACT. In peripartum dairy cows, insulin resistance (IR) increases to adjust the direction of energy to lactation after calving. To investigate the effect of prepartum IR on postpartum reproductive performance, the insulin tolerance test (ITT) was applied to 15 cows at 3 weeks (Pre21) and 10 days (Pre10) before the predicted calving date. blood glucose area under the curve (AUC glu ) within 120 min after administration of 0.05 IU/kg-BW insulin was calculated. The occurrence of first ovulation, days to first artificial insemination (AI) and first AI conception rate were recorded. Nutritional status postpartum was evaluated by blood chemical analysis. Based on AUC glu changes from Pre21 to Pre10, cows were classified into either the AUC-up group (AUC glu increase, n=5) or the AUC-down group (AUC glu decrease, n=10). There was no difference in the decrease in blood glucose at 30 min after insulin injection between groups, although glucose recovery from 30 to 60 min during the ITT was slow at Pre10 in the AUC-up group. The AUC-up group had a higher number of days to first AI and high glucose, total protein, globulin, γ-glutamyltransferase, triacylglycerol levels and a low albumin-globulin ratio at the 14th day postpartum. The present study infers that prepartum slow glucose recovery rather than insulin sensitivity might increase the potential for subclinical health problems postpartum and thus suppress reproductive performance. During the prepartum transition period, glucose dynamics in the ITT can be considered as a new indicator for the postpartum metabolic status and reproductive performance of dairy cows.

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Effects of long-term ad libitum feeding on plasma lipid components and blood glucose, β-hydroxybutyrate and insulin concentrations in lean adult sheep

Abstract: Summary. The long-term changes in plasma lipid composition and blood glucose, (3-

Cited by 17 publications

References 6 publications

Qualitative behavioral assessment of transport-naïve and transport-habituated sheep

Qualitative behavioral assessment of transport-naïve and transport-habituated sheep

Changes in Insulin, Glucose and Ketone Bodies, But Not Leptin or Body Fat Content Precede Restoration of Luteinising Hormone Secretion in Ewes

Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows

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