Effects of Long-Term Boron Administrations on High-Energy Diet-Induced Obesity in Rabbits: NMR-Based Metabonomic Evaluation

Basoglu, Abdullah; Başpınar, Nuri; Öztürk, Atakan; Akalın, Pınar Peker

doi:10.3923/javaa.2011.1512.1515

Cited by 18 publications

(6 citation statements)

References 9 publications

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“…Our observation of an inverse association of BMI with circulating boron is comparable with results from experimental studies showing a reduction in body weight and obesity with boron administration in animal models [ 31 , 32 ]. Proposed mechanisms are the overexpression of thermogenic proteins in murine adipose and skeletal muscle tissue, resulting in accelerated lipolysis and body weight loss [ 33 ].…”

Section: In the Context Of The Published Literaturesupporting

confidence: 90%

Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates

et al. 2021

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Purpose Experimental evidence suggests positive effects of boron on health and metabolism, but human data are still scarce. We aimed to identify dietary and cardio-metabolic correlates of plasma boron concentrations in the general population. Methods In a community-based sample (n = 899, 57% men, mean age 61 years), plasma boron (median [IQR]: 33.80 µg/L [25.61; 44.65]) concentrations were measured by inductively coupled plasma-mass spectrometry. Overall (PDI), healthy (hPDI), and unhealthy (uPDI) plant-based diet indices were derived from a validated food frequency questionnaire. Reduced rank regression (RRR) yielded a dietary pattern explaining 30% of the variation of circulating boron. Cross-sectional associations of dietary indices and cardio-metabolic traits with plasma boron concentrations were assessed using multivariable-adjusted linear regression analysis. Results The RRR pattern was characterized by high intake of fruits, nuts/seeds, tea, wine and low intake of e.g. bread, poultry, processed meat, chocolate/sweets, and soft drinks. 10-point increments in PDI, hPDI, and uPDI were associated with 8.7% (95% CI: 4.2; 13.4), 10.4% (95% CI: 6.6; 14.3), and −8.8% (95% CI: −12.1; −5.4) change in plasma boron concentrations, respectively. Age and phosphate were directly, while BMI, plasma lipid concentrations, and CRP were inversely associated with circulating boron. Plasma boron concentrations were higher in summer vs. winter, in individuals taking vs. not taking antihypertensive medication, and in individuals with high or medium vs. low education level. Conclusion Higher plasma boron concentrations appeared to associate with a healthier diet, were related to lower BMI and a more favorable cardio-metabolic risk profile, and showed seasonal variations.

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Section: In the Context Of The Published Literaturesupporting

confidence: 90%

Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates

et al. 2021

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“…The boron compounds in animal metabolism protect against the development and decrease in triglyceride, notably low-density lipoprotein, total cholesterol, insulin, and non-esterified fatty acids in serum (Basoglu et al 2002;Kabu and Civelek 2012). Moreover, boron plays a part in the oxidative stress reducing mechanisms such as the glucose-alanine cycle and methionine metabolism, and boron positively affects the lipid profile (Basoglu et al 2011). Additionally, boron has many effects related to the bone metabolism in animals.…”

Section: Discussionmentioning

confidence: 99%

Effect of boric acid in rainbow trout (Oncorhynchus mykiss) growth performance

Öz

İnanan

Dikel

2018

Journal of Applied Animal Research

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The effects of different levels of boron supplementation to feed on the growth parameters of rainbow trout (Oncorhynchus mykiss) were investigated for the first time using four diet variations (0.01%, 0.05%, 0.10%, and 0.20% of boron in feed) in addition to a control diet (without boron). After 120 days of feeding, the final weight (FW), weight gain, condition factor, feed intake, feed conversion rates, specific growth rate, protein efficiency ratio, survival rates, economic conversion rate, and economic profit index were calculated for each treatment and compared with the control as growth parameters. The initial weight was 17.89 ± 1.12 g; at the end of feeding, the FWs were determined as 89.91 ± 2.11 g for the control and 90.56 ± 1.34 g, 99.21 ± 3.76 g, 88.14 ± 2.43 g, and 78.74 ± 1.47 g for 0.01%, 0.05%, 0.10%, and 0.20% of boron feed treatments, respectively. The results of this study show that feeding rainbow trout with 0.05% boron-supplemented feed stimulates the growth parameters, but 0.20% of boron supplementation inhibits the growth of rainbow trout. ARTICLE HISTORY

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“…This opens opportunities for further investigation into SBE metabolism and also for use of this technology for investigation into transport of sugar derivatives of other elements of nutritional importance (for example, magnesium or selenium). The biological and clinical benefits observed thus far for CaFB [ 17 , 27 , 29 , 30 , 33 , 54 , 55 ] suggest that B-containing sugars are indeed unique and extraordinary participants in the realm of B-containing molecules.…”

Section: Natural Occurrence and Intakementioning

confidence: 99%

The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review

Hunter

Nemzer

Rangavajla

et al. 2018

Biol Trace Elem Res

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Sugar–borates (SBs) are mono- or di-sugar–borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary natural dietary sources of B-containing molecules in humans. To date, the most studied SBE is calcium fructoborate (CaFB). CaFB represents an important example of how organic B-containing molecules are significantly distinct from their inorganic counterparts. During these past two decades, CaFB has been researched for its physical and biochemical characteristics, safety, and clinical outcomes. Results of these researches are presented and discussed herein. CaFB has been characterized using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), high-performance thin-layer chromatography (HPTLC), nuclear magnetic resonance (NMR), liquid chromatography–multistage accurate mass spectrometry (LC-MSn), X-ray diffraction (XRD), Raman spectroscopy, and inductively coupled plasma (ICP) in non-biological and biological specimens. Potential health benefits of CaFB have been clinically investigated in pilot and efficacy studies demonstrating (i) significant reductions in knee discomfort and improved flexibility within 7, 14, and 90 days and (ii) significant effect on blood levels of inflammatory, cardiovascular, and other biomarkers. These studies support the use of CaFB as a dietary supplement for the management of joint discomfort. CaFB is presented here in order to illustrate how physiological benefits are imparted by distinct organic boron-containing molecules rather than solely by the element B itself. Considering recent National Health and Nutrition Examination Survey (NHANES) data reporting increases in age-related joint pain and an increasing elderly demographic, SBEs offer potential for safe, natural, and effective management of joint discomfort and improved mobility in human and animal health applications. Several of these studies may also open new opportunities for use of SBEs for health benefits beyond joint health.

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Effects of Long-Term Boron Administrations on High-Energy Diet-Induced Obesity in Rabbits: NMR-Based Metabonomic Evaluation

Cited by 18 publications

References 9 publications

Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates

Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates

Effect of boric acid in rainbow trout (Oncorhynchus mykiss) growth performance

The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review

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