Effects of Long-Term Feeding of Fat-Free Diets to Cebus Monkeys

Red-Cell and Plasma Lipids in Acanthocytosis*

“…Plasma lipid and lipoprotein values for the family members are shown in Table III (26) and monkeys (27)(28)(29), decreased percentages (absolute levels were not measured) of red-cell linoleate follow prolonged dietary restriction of linoleic acid. Similarly, our analyses of red cells from other subjects with steatorrhea, or malnutrition, or both, generally showed reduction of red-cell linoleate.…”

“…There is another interesting difference between the deficient animals and the patients with malabsorption (whether due to acanthocytosis or not). In the experimentally deficient animals, there is marked increase of a red-cell fatty acid with the chromatographic retention characteristics of eicosatrienoic acid (27)(28)(29) Erythrocyte plasmalogens, which were also decreased in the acanthocyte, were determined in only two of the other types of malabsorption, and on a per cell basis were normal. Since in normal red cells 8 to 10% of total plasmalogens are in the lecithin fraction (19), part of their decrease in acanthocytes may be related to the deficiency in red-cell lecithin.…”

Essential Fatty Acid Studies in Primates Linolenic Acid Requirements of Capuchins

“…Thus, as is common practice, he does not distinguish between the acids of the linoleic and linolenic series. Portman [11] recommends a figure of 250 mg linoleic acid per day as the minimum requirement for Macaco mulatta and Cebus based on experimental work employing vegetable oils as a source of EFA [3,6,12,13]. It is usually assumed that the vegetable oils provide linoleic acid as the only polyunsaturated fatty acid (PUFA) whereas in general most oils also contain small amounts of linolenic acid in addition to linoleic [8], Requirements for linolenic acid are not defined, its presence ignored, or it is considered unnecessary.…”

Fatty Acid Composition of Phospholipids in Erythrocytes of Adults, Normal Newborn Infants, and Neonates with Rh Erythroblastosis

“…It is, however, remarkable that there is a similarity in the changes in fatty acid composition caused by an essential fatty acid deficiency and by abetalipoproteinemia where a malabsorption of essential fatty acids is assumed [31,45]. By dietary experiments it was proven that the smaller content of 18: 2 n _ 6 , the greater formation of 20: 3 n _ 9 and the greater proportion of polyunsaturated fatty acids are characteristic of a deficiency of essential fatty acids [13,17,22,32,[41][42][43].…”