Effects of long-term restricted feeding on motor activity rhythm in the rat

Cambras, Trinitat; Vilaplana, Jordi; Dı́ez-Noguera, Antoni

doi:10.1152/ajpregu.1993.265.2.r467

Cited by 10 publications

(9 citation statements)

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“…Restricting food to a particular time of day during RF results in profound behavioral and physiological changes (reviewed in Escobar et al 2009). Briefly, mice display food anticipatory activity (FAA), characterized by increased locomotor activity, body temperature, and corticosterone secretion 2–4 h before the presentation of food (Nelson et al 1975; Duffy et al 1990; Cambras et al 1993; Challet et al 1997). Although the clock probably plays a critical role in FAA, as mice deficient in Per2 do not display the anticipatory increase in activity (Feillet et al 2006), FAA does persist in mice lacking Bmal1 (Pendergast et al 2009; Storch and Weitz 2009).…”

Section: Response Of Circadian Clock To Changes In Nutrient Availabilitymentioning

confidence: 99%

“…However, unlike RF, CR also entrains the SCN clock (Cambras et al 1993; Challet et al 1998; Challet et al 2003; Mendoza et al 2005; Resuehr and Olcese 2005; Mendoza et al 2007), suggesting that hypocaloric feeding itself is responsible for modulating the master pacemaker. When interpreting the effects of CR versus RF on the circadian clock, it is important to note that some of the effects of CR may actually be due to the altered timing of feeding rather than the reduced total caloric intake, as many CR protocols provide a set amount of food at a given time during the light period (i.e., the normal rest period for mice), similar to the timing of food provided during RF.…”

Section: Response Of Circadian Clock To Changes In Nutrient Availabilitymentioning

confidence: 99%

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Circadian Clocks in Fuel Harvesting and Energy Homeostasis

Ramsey

Bass²

2011

Cold Spring Harbor Symposia on Quantitative Biology

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Circadian systems have evolved in plants, eubacteria, neurospora, and the metazoa as a mechanism to optimize energy acquisition and storage in synchrony with the rotation of the Earth on its axis. In plants, circadian clocks drive the expression of genes involved in oxygenic photosynthesis during the light and nitrogen fixation during the dark, repeating this cycle each day. In mammals, the core clock in the suprachiasmatic nucleus (SCN) functions to entrain extra-SCN and peripheral clocks to the light cycle, including regions central to energy homeostasis and sleep, as well as peripheral tissues involved in glucose and lipid metabolism. Tissue-specific gene targeting has shown a primary role of clock genes in endocrine pancreas insulin secretion, indicating that local clocks play a cell-autonomous role in organismal homeostasis. A present focus is to dissect the consequences of clock disruption on modulation of nuclear hormone receptor signaling and on posttranscriptional regulation of intermediary metabolism. Experimental genetic studies have pointed toward extensive interplay between circadian and metabolic systems and offer a means to dissect the impact of local tissue molecular clocks on fuel utilization across the sleep–wake cycle.

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Section: Response Of Circadian Clock To Changes In Nutrient Availabilitymentioning

confidence: 99%

Section: Response Of Circadian Clock To Changes In Nutrient Availabilitymentioning

confidence: 99%

Circadian Clocks in Fuel Harvesting and Energy Homeostasis

Ramsey

Bass²

2011

Cold Spring Harbor Symposia on Quantitative Biology

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“…For instance, it reduces fat reserves and serum leptin concentrations (Rousseau et al 2002), suppresses serum gonadotropins, and induces increased anabolic and decreased catabolic gene expression in the arcuate nucleus (Korcsynska et al 2003). Food restriction decreases the amount and phase advances the rhythm of the locomotor activity in rats (Cambras et al 1993;Challet et al 1997) and field mouse Mus booduga (Sharma et al 2000). Restricted feeding during the naturally inactive phase (day time for nocturnal and night time for diurnal species) induces a decrease in food intake.…”

Section: Discussionmentioning

confidence: 99%

The effects of photoperiod and age on food anticipatory activity in Mongolian gerbils (Meriones unguiculatus)

Karakaş

2010

Biological Rhythm Research

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In many animal models, the circadian rhythm of locomotor activity is regulated by at least two external pacemakers, environmental photoperiod and food availability. Entrainment with food is characterized by an anticipatory increase in locomotor activity before mealtime. In the present study, the effects of photoperiod and age on the food anticipatory activity (FAA) of Mongolian gerbils were investigated. The experiments were performed under long (14L:10D) and short photoperiods (8L:16D) in young (3 months old) and old (2 years old) adult male gerbils. Food was given only for two hours (11 am-1 pm) during the light phase. Food restriction created FAA in the gerbils. The wheel turn performance of the gerbils was affected by photoperiod, age of the gerbil and food restriction in both light and dark phases. The gerbils experiencing the short photoperiod did perform better than those experiencing the long photoperiod. Young gerbils did perform better than old ones. The light/dark ratio in locomotor activity was affected significantly by photoperiod and food restriction. Food intake of the gerbils was affected by photoperiod, age, and food restriction. In conclusion, photoperiod, age of the gerbil and the food availability were found to be effective in the regulation of FAA in Mongolian gerbils.

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“…On the other hand, motor activity circadian rythm of the rat is driven by both light-dark cycle and by time of feeding (Cambras et al, 1993). Usually, food restricted animals are considered less active than the ad libitum fed ones.…”

Section: Discussionmentioning

confidence: 99%

Energy expenditure of rats subjected to long-term food restriction

Santos-Pinto

Luz²,

Griggio³

2001

International Journal of Food Sciences and Nutrition

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Food restriction, even when expressed per unit of metabolic mass, leads to energy conservation as seen by decreased oxygen consumption. The objective of the present study was to verify whether the energy conservation mechanism reduces energy expenditure for as long as food restriction lasts or whether a return to basal level may occur without realimentation, mainly in mildly food-restricted rats. Wistar rats were brought to the laboratory on weaning. They were then assigned to control group that received ad libitum food intake, R10 and R20 groups that received 90 and 80%, respectively, of the food eaten by control group and RM group that received an amount of food enough only to keep body weight. The food restriction period lasted for 3 months and was followed by another month during which all groups received ad libitum food intake. The results showed that even in animals subjected to mild food restriction (10%) there was a sustained decrease in oxygen consumption that lasted until refeeding of the animals. The results led to the conclusion that the energy conservation mechanism is active from little food restriction until more stronger levels of restriction, in a proportional manner, and the decreased energy expenditure is maintained during the whole food restriction period.

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Effects of long-term restricted feeding on motor activity rhythm in the rat

Cited by 10 publications

References 0 publications

Circadian Clocks in Fuel Harvesting and Energy Homeostasis

Circadian Clocks in Fuel Harvesting and Energy Homeostasis

The effects of photoperiod and age on food anticipatory activity in Mongolian gerbils (Meriones unguiculatus)

Energy expenditure of rats subjected to long-term food restriction

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