Effects of long-term sex steroid hormones (estradiol and testosterone)–supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis)

Zhang, Mengqian; Yang, Qian; Shi, Rui; Wang, Jialin; Zhang, Ziwei; Yang, Yingming; Li, Wenlong; Chen, Songlin; Wang, Na

doi:10.1007/s10695-022-01125-w

Cited by 11 publications

(2 citation statements)

References 52 publications

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“…Furthermore, the four signature piRNAs and their target genes were related to in utero embryonic development, oocyte meiosis, the TGF-β signaling pathway, progesterone-mediated oocyte maturation, and the GnRH signaling pathway. In the hypothalamus–pituitary–gonad axis in fish, GnRH secreted from the hypothalamus regulates gonadotropin (Gn) secretion from the pituitary, thus regulating sex hormone secretion and synthesis from the gonads [ 50 , 51 , 52 , 53 ]. In addition, sex hormone-binding globulin (SHBG) in the blood binds to and transports hormones, including GnRH, Gn, and sex hormones, to target organs, including gonads [ 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

Deng

Zhao

et al. 2023

IJMS

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The greater amberjack (Seriola dumerili) is a gonochoristic fish with no sexual dimorphism in appearance, making sex identification difficult. Piwi-interacting RNAs (piRNAs) function in transposon silencing and gametogenesis and are involved in various physiological processes, including sex development and differentiation. Exosomal piRNAs can be indicators for the determination of sex and physiological status. In this study, four piRNAs were differentially expressed in both serum exosomes and gonads between male and female greater amberjack. Three piRNAs (piR-dre-32793, piR-dre-5797, and piR-dre-73318) were significantly up-regulated and piR-dre-332 was significantly down-regulated in serum exosomes and gonads of male fish, compared to female fish, consistent with the serum exosomal results. According to the relative expression of four marker piRNAs derived from the serum exosomes of greater amberjack, the highest relative expression of piR-dre-32793, piR-dre-5797, and piR-dre-73318 in seven female fish and that of piR-dre-332 in seven male fish can be used as the standard for sex determination. The method of sex identification can ascertain the sex of greater amberjack by blood collection from the living body, without sacrificing fish. The four piRNAs did not show sex-inclined expression in the hypothalamus, pituitary, heart, liver, intestine, and muscle tissue. A piRNA–target interaction network involving 32 piRNA-mRNA pairs was generated. Sex-related target genes were enriched in sex-related pathways, including oocyte meiosis, transforming growth factor-beta signaling pathway, progesterone-mediated oocyte maturation, and gonadotropin releasing hormone signaling pathway. These results provide a basis for sex determination in greater amberjack and improve our understanding of the mechanisms underlying sex development and differentiation in the species.

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Section: Discussionmentioning

confidence: 99%

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

Deng

Zhao

et al. 2023

IJMS

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“…The formation of SSD is usually related to the allometric growth and natural selection in different sexes [ 4 ]. Sex steroids and the somatotrophic axis (mainly GH-IGF1 system) have been reported to influence the sexual allometric growth [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Three Copies of zbed1 Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in Cynoglossus semilaevis

Sun,

Li,

Mai

et al. 2024

Biology

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The sex chromosome, especially specific in one sex, generally determines sexual size dimorphism (SSD), a phenomenon with dimorphic sexual difference in the body size. For Cynoglossus semilaevis, a flatfish in China, although the importance of chromosome W and its specific gene zbed1 in female-biased SSD have been suggested, its family members and regulation information are still unknown. At present, three zbed1 copies gene were identified on chromosome W, with no gametologs. Phylogenetic analysis for the ZBED family revealed an existence of ZBED9 in the fish. Nine members were uncovered from C. semilaevis, clustering into three kinds, ZBED1, ZBED4 and ZBEDX, which is less than the eleven kinds of ZBED members in mammals. The predominant expression of zbed1 in the female brain and pituitary tissues was further verified by qPCR. Transcription factor c/ebpα could significantly enhance the transcriptional activity of zbed1 promoter, which is opposite to its effect on the male determinant factor-dmrt1. When zbed1 was interfered with, piwil1, esr2 and wnt7b were up-regulated, while cell-cycle-related genes, including cdk4 and ccng1, were down-regulated. Thus, zbed1 is involved in cell proliferation by regulating esr2, piwil1, cell cycle and the Wnt pathway. Further research on their interactions would be helpful to understand fish SSD.

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Novel single nucleotide polymorphisms of insulin-like growth factor-binding protein 7 (IGFBP7) gene significantly associated with growth traits in striped catfish (Pangasianodon hypophthalmus Sauvage, 1878)

Tran

et al. 2023

Mol Genet Genomics

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Effects of long-term sex steroid hormones (estradiol and testosterone)–supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis)

Cited by 11 publications

References 52 publications

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

Sex-Inclined Piwi-Interacting RNAs in Serum Exosomes for Sex Determination in the Greater Amberjack (Seriola dumerili)

Three Copies of zbed1 Specific in Chromosome W Are Essential for Female-Biased Sexual Size Dimorphism in Cynoglossus semilaevis

Novel single nucleotide polymorphisms of insulin-like growth factor-binding protein 7 (IGFBP7) gene significantly associated with growth traits in striped catfish (Pangasianodon hypophthalmus Sauvage, 1878)

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