Effects of Long-Term Treatment with Taurine in Mice Fed a High -Fat Diet

Murakami, Shigeru; Kondo, Yukiko; Nagate, Takatoshi

doi:10.1007/0-306-46838-7_19

Cited by 32 publications

(5 citation statements)

References 37 publications

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“…Interestingly, taurine level was formerly decreased by 60% in HFD group compared to Con group. The decrease may be attributed to the increasing conjunction of taurine with bile acid, whose synthesis was up-regulated in hyperlipidemia [ 34 ]. Thus elevated taurine levels in Cur2 group indicated that synthesis of cholesterol was suppressed after supplement of curcumin, as had been previously reported [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

1H-NMR and MS Based Metabolomics Study of the Intervention Effect of Curcumin on Hyperlipidemia Mice Induced by High-Fat Diet

Ding

et al. 2015

PLoS ONE

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Curcumin, a principle bioactive component of Curcuma longa L, is well known for its anti-hyperlipidemia effect. However, no holistic metabolic information of curcumin on hyperlipidemia models has been revealed, which may provide us an insight into the underlying mechanism. In the present work, NMR and MS based metabolomics was conducted to investigate the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet (HFD) feeding for 12 weeks. The HFD induced animals were orally administered with curcumin (40, 80 mg/kg) or lovastatin (30 mg/kg, positive control) once a day during the inducing period. Serum biochemistry assay of TC, TG, LDL-c, and HDL-c was conducted and proved that treatment of curcumin or lovastatin can significantly improve the lipid profiles. Subsequently, metabolomics analysis was carried out for urine samples. Orthogonal Partial Least Squares-Discriminant analysis (OPLS-DA) was employed to investigate the anti-hyperlipidemia effect of curcumin and to detect related potential biomarkers. Totally, 35 biomarkers were identified, including 31 by NMR and nine by MS (five by both). It turned out that curcumin treatment can partially recover the metabolism disorders induced by HFD, with the following metabolic pathways involved: TCA cycle, glycolysis and gluconeogenesis, synthesis of ketone bodies and cholesterol, ketogenesis of branched chain amino acid, choline metabolism, and fatty acid metabolism. Besides, NMR and MS based metabolomics proved to be powerful tools in investigating pharmacodynamics effect of natural products and underlying mechanisms.

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Section: Resultsmentioning

confidence: 99%

1H-NMR and MS Based Metabolomics Study of the Intervention Effect of Curcumin on Hyperlipidemia Mice Induced by High-Fat Diet

Ding

et al. 2015

PLoS ONE

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“…As a naturally occurring amino acid, taurine should display minimal side effects in the body. According to toxicity studies, it did not produce genotoxic, carcinogenic or teratogenic effects [16,[26], [27], [28]]. However, a few studies reported tolerable limits of taurine considering the No Observed Adverse Effect Level (NOAEL).…”

Section: Overview Of Taurinementioning

confidence: 99%

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

et al. 2019

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Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is produced chiefly by the liver and kidney. It presents in different organs, including retina, brain, heart and placenta and demonstrates extensive physiological activities within the body. In the several disease models, it attenuates inflammation- and oxidative stress-mediated injuries. Taurine also modulates ER stress, Ca 2+ homeostasis and neuronal activity at the molecular level as part of its broader roles. Different cellular processes such as energy metabolism, gene expression, osmosis and quality control of protein are regulated by taurine. In addition, taurine displays potential ameliorating effects against different neurological disorders such as neurodegenerative diseases, stroke, epilepsy and diabetic neuropathy and protects against injuries and toxicities of the nervous system. Several findings demonstrate its therapeutic role against neurodevelopmental disorders, including Angelman syndrome, Fragile X syndrome, sleep-wake disorders, neural tube defects and attention-deficit hyperactivity disorder. Considering current biopharmaceutical limitations, developing novel delivery approaches and new derivatives and precursors of taurine may be an attractive option for treating neurological disorders. Herein, we present an overview on the therapeutic potential of taurine against neurological disorders and highlight clinical studies and its molecular mechanistic roles. This article also addresses the neuropharmacological potential of taurine analogs.

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“…Previous clinical studies have reported that taurine does not induce genotoxic, carcinogenic or teratogenic effects in stroke or heart ischemia patients 32 – 34 . In Murakami et al’s study 35 , no specific side effects were observed when C57BL/6J mice were treated with taurine for 6 months. Our study also revealed no severe side effects in rodents despite the long-term use of taurine for 7 months.…”

Section: Discussionmentioning

confidence: 89%

Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging

Lee

Jeong

et al. 2020

Sci Rep

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Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the leading cause of dementia, but therapeutic treatment options are limited. Taurine has been reported to have neuroprotective properties against dementia, including AD. The present study aimed to investigate the treatment effect of taurine in AD mice by functional molecular imaging. To elucidate glutamate alterations by taurine, taurine was administered to 5xFAD transgenic mice from 2 months of age, known to apear amyloid deposition. Then, we performed glutamate positron emission tomography (PET) imaging studies for three groups (wild-type, AD, and taurine-treated AD, n = 5 in each group). As a result, brain uptake in the taurine-treated AD group was 31–40% higher than that in the AD group (cortex: 40%, p < 0.05; striatum: 32%, p < 0.01; hippocampus: 36%, p < 0.01; thalamus: 31%, p > 0.05) and 3–14% lower than that in the WT group (cortex: 10%, p > 0.05; striatum: 15%, p > 0.05; hippocampus: 14%, p > 0.05; thalamus: 3%, p > 0.05). However, we did not observe differences in Aβ pathology between the taurine-treated AD and AD groups in immunohistochemistry experiments. Our results reveal that although taurine treatment did not completely recover the glutamate system, it significantly increased metabolic glutamate receptor type 5 brain uptake. Therefore, taurine has therapeutic potential against AD.

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Effects of Long-Term Treatment with Taurine in Mice Fed a High -Fat Diet

Cited by 32 publications

References 37 publications

1H-NMR and MS Based Metabolomics Study of the Intervention Effect of Curcumin on Hyperlipidemia Mice Induced by High-Fat Diet

1H-NMR and MS Based Metabolomics Study of the Intervention Effect of Curcumin on Hyperlipidemia Mice Induced by High-Fat Diet

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging

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