Effects of long-term treatment with eicosapentaenoic acid on the heart subjected to ischemia/reperfusion and hypoxia/reoxygenation in rats

Highly Purified Eicosapentaenoic Acid Ethyl Ester Prevents Development of Steatosis and Hepatic Fibrosis in Rats

“…Another group was fed the MCS diet as a control. Plasma EPA level following administration of EPA-E to rats at 1,000 mg/kg/day for 4 weeks has been reported to be 62 lg/mL [19], which is less than that in humans given a clinical dose of EPA-E (1,800 mg/day) for 3 months (143 lg/mL) [20]. Therefore, 1,000 mg/kg/day was considered to be an appropriate dose for investigation of the pharmacological effects of EPA-E in rats.…”

Eicosapentaenoic Acid Attenuates Progression of Hepatic Fibrosis with Inhibition of Reactive Oxygen Species Production in Rats Fed Methionine- and Choline-Deficient Diet

“…At 12 weeks, the MCD-fed group was again randomly divided into two groups of 20 rats, and one group was administered EPA-E (1,000 mg/kg) daily by gavage with MCD feeding until 20 weeks. The dose of EPA-E (1,000 mg/kg/day) was considered to be appropriate for investigation of the pharmacological effects of EPA-E and its underlying mechanisms in rats, because plasma EPA level following administration of EPA-E to rats at 1,000 mg/kg/day for 4 weeks has been reported to be 62 lg/mL [31], which is almost comparable to that in humans given a clinical dose of EPA-E (1,800 mg/day) for 3 months (143 lg/mL) [32]. Groups not given EPA-E were also administered 5% arabic gum solution as vehicle from week 12 to 20 with feeding of the respective diet.…”

Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-β1 and phosphorylated JNK

“…Although there is no overwhelming consensus concerning the protective role of dietary fish oil in coronary artery disease (36), a significant number of experimental studies and clinical intervention trials have shown a cardioprotective effect of dietary fish and fish oil intake (19,43). Among them, -3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have recently been shown to have potential beneficial effects on cardiovascular diseases (8,11).…”