Effects of loratadine/montelukast on vigilance and alertness task Performance in a simulated cabin environment

Abstract

L/M is similar to placebo in effects on daytime somnolence and psychomotor performance. L/M treatment resulted in significantly less sleepiness and impairment of vigilance and tracking than diphenhydramine.

A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins

“…Furthermore, affinity at 5‐HT 2B and α 1B ‐ adrenoceptors may predict ligand promiscuity (Peters et al, 2012) and high affinity antagonism of central α 1A/1B ‐adrenoceptors is associated with adverse events such as orthostatic hypotension, dizziness and sedation (Andersson & Gratzke, 2007). Similarly, antagonism of central H 1 receptors is linked to sedation in humans (Nicholson et al, 1991; Stahl, 2008; Valk & Simons, 2009). The lead 4‐PATs from this study, (2 S ,4 R )‐ 2k and (2 R ,4 R )‐ 3h , displayed high selectivity to bind 5‐HT 2A /5‐HT 2C receptors over 5‐HT 1A , 5HT 2B , 5HT 7 , D 2 , D 3 , α 1A ‐ and α 1B ‐adrenoceptors (>100‐fold), whereas selectivity over H 1 receptors was moderate for (2 S ,4 R )‐ 2k (~38‐fold).…”

A study of effect of a single dose of second generation antihistaminics on cognitive and psychomotor function in healthy human volunteers

“…Valk et al studied the adverse effects of H1 antihistaminics (mainly first generation) can interfere with the performance of daytime activities and place the patient at risk of accidents in situations such as driving and operation of machinery. 7 Church et al studied effects of first-generation H1 antihistamines on the CNS are similar to and additive with those produced by ethanol or other CNS-sedatives, such as benzodiazepines. 16 Sen et al examined The Civil Aerospace Medical Institute's (CAMI's) Toxicology database for the presence of the first-generation antihistamines in pilot fatalities of civil aircraft accidents that occurred during a 16-year (1990-2005) period.…”

“…6 alertness as driver of motor vehicle, pilot of aircraft, machinery operators, students who need full attention at the time of examination, candidate facing some interview for job. [4][5][6][7][8] A large number of studies have been carried out to assess psychomotor performance and the sedative effect of the H1 antihistamines. 9 There are very few studies in Indian population.…”

Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial

“…The Vigilance and Tracking test (VigTrack) is a dual-task that measures vigilance performance under the continuous load of a compensatory tracking task. The test has been used in various studies and is sensitive for measuring vigilance and alertness (Simons, 2017; Valk and Simons, 2009). During the tracking task, participants had to steer a blue dot using a joystick such that it remained below a red dot in the center of the display.…”