Effects of lorazepam on visual perceptual abilities

Abstract

Acute administration of lorazepam, in a dose that impaired episodic memory, selectively affected different visual perceptual abilities before and after controlling for sedation. Central executive demands and sedation did not account for results, so impairment in the Identical Pictures task may be attributed to lorazepam's visual processing alterations.

Acute lorazepam effects on neurocognitive performance

“…The presence of LOR effects at this dosage on these domains is consistent with previous reports of acute LOR exposure [6,16].…”

Acute cognitive effects of donepezil in young, healthy volunteers

“…The advantage in memorizing visual stimuli possibly owe to improvement in visual processing (see Furey et al, 2008a) elicited by this drug and observed as a shortening of IT. It also may relate to the improvement found in executive mechanisms because even simple visuospatial tasks seem to heavily implicate central executive functioning (Baddeley et al, 1999;Miyake et al, 2001;Pompéia et al, 2008).…”

The Effects of Vortioxetine on Cognitive Function in Patients with Major Depressive Disorder: A Meta-Analysis of Three Randomized Controlled Trials

“…Studies of DSST performance relative to placebo have shown effect sizes (Cohen’s d ) of 0.25–0.5 for diphenhydramine (Roth et al, 1987) and lorazepam (Pompeia et al, 2008), and 0.68 in people whose blood alcohol concentration is 0.09% (Mattila and Mattila-Evenden, 1997; national guidelines usually stipulate an upper threshold of either 0.05 or 0.08%; ). Importantly, while the effects of these agents cease once the drug effects wear off, the effects of cognitive dysfunction in chronic MDD are far more persistent.…”