Effects of Low-Dose Aspirin Combined with Vitamin E on the Incidence of Intrauterine Growth Restriction and Hemorheological Indexes of Pregnant Women in Patients with Gestational Hypertension

Abstract

Objective. To investigate the effect of low-dose aspirin combined with vitamin E on the incidence of intrauterine growth restriction and hemorheological indexes of pregnant women in patients with gestational hypertension. Method. 134 elderly patients with chronic urticaria treated in our hospital from November 2017 to November 2020 were studied. According to the treatment methods, they were randomly divided into observation and control groups. There were 67 patients in the observation group, aged 20-37 years, with an average of ( 25.7 ± 2.75 ) years. There were 67 patients in the control group, aged 21-35 years, with an average of ( 26.3 ± 3.17 ) years. No significant difference was observed between the two groups ( P > 0.05 ). Results. The number of cases with postpartum hemorrhage and intrauterine growth restriction in the observation group was less than that in the control group. The total incidence rate was lower than that in the control group. There were significant differences in the above results ( P < 0.05 ). The number of patients with preterm birth in the observation group was less than that in the control group, but there was no significant difference in the results ( P > 0.05 ). The head circumference, abdominal circumference, biparietal diameter, and femoral length diameter in the control and observation groups increased significantly after treatment ( P < 0.05 ). Compared with the control group, the head circumference, abdominal circumference, biparietal diameter, and femoral diameter in the observation group increased more after treatment, and the results were statistically poor ( P < 0.05 ). The systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the control and observation groups decreased significantly after treatment, and the results were statistically different ( P < 0.05 ). Compared with the control group, the systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the observation group decreased more after treatment. The results were statistically different ( P < 0.05 ). The plasma viscosity levels, whole blood high shear viscosity, and whole blood low shear viscosity in the control and observation groups decreased significantly after treatment, and the results were statistically different ( P < 0.05 ). Compared with the control group, plasma viscosity levels, whole blood high shear viscosity, and whole blood low shear viscosity in the observation group decreased more after treatment, and the results were statistically different ( P < 0.05 ). The control and observation groups’ fetal systolic/diastolic pressure and pulsatile index decreased significantly after treatment, and the results were statistically different ( P < 0.05 ). Compared with the control group, the fetal systolic/diastolic blood pressure and pulsatile index in the observation group decreased more after treatment, and the results were statistically poor ( P < 0.05 ). Conclusion. Low-dose aspirin combined with vitamin E is effective in treating intrauterine growth restriction in patients with gestational hypertension. It can effectively control the blood pressure and blood flow of patients and newborns and improve pregnancy outcomes without increasing the incidence of adverse reactions. It is worthy of clinical promotion.

Low-dose aspirin in the prevention of pre-eclampsia in China: postpartum hemorrhage in subgroups of women according to their characteristics and potential bleeding risk

“…[ 9 , 10 , 25 , 26 ] Several studies have even found that the prophylactic effect of aspirin has a protective effect on PPH. [ 27 , 28 ] The secondary analysis of the APPEC study demonstrated that in pregnant women with high-risk factors for developing pre-eclampsia, the prophylactic administration of low-dose aspirin from 12 weeks to 20 weeks of gestation until 34 weeks of gestation or in the event of early delivery would not increase the incidence of PPH or decrease the incidence of PPH. There was no evidence of heterogeneity in the incidence of PPH in subgroups defined according to maternal characteristics.…”

“…Some research aimed to evaluate the relationship between the incidence of PPH and the prophylactic administration of low-dose aspirin showed that aspirin will not increase the risk of PPH and other bleeding events, [17–24] but some studies indicated that there was an increased risk of PPH [9,10,25,26] . Several studies have even found that the prophylactic effect of aspirin has a protective effect on PPH [27,28] . The secondary analysis of the APPEC study demonstrated that in pregnant women with high-risk factors for developing pre-eclampsia, the prophylactic administration of low-dose aspirin from 12 weeks to 20 weeks of gestation until 34 weeks of gestation or in the event of early delivery would not increase the incidence of PPH or decrease the incidence of PPH.…”

Retracted: Effects of Low‐Dose Aspirin Combined with Vitamin E on the Incidence of Intrauterine Growth Restriction and Hemorheological Indexes of Pregnant Women in Patients with Gestational Hypertension

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”