2006
DOI: 10.1016/j.ijheh.2006.06.004
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Effects of low-dose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells

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Cited by 102 publications
(55 citation statements)
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“…34,35,36,37 In that manner, standard alkaline and Fpg-modified version of the comet assay were used as well as the DNA diffusion test to access whether this type of radiation induces apoptotic or necrotic cell death. Techniques used in this study showed genotoxic effect of gamma rays on DNA molecule of peripheral blood human lym- phocytes in vitro.…”
Section: Comet Assay and Fpg-modified Comet Assaymentioning
confidence: 99%
“…34,35,36,37 In that manner, standard alkaline and Fpg-modified version of the comet assay were used as well as the DNA diffusion test to access whether this type of radiation induces apoptotic or necrotic cell death. Techniques used in this study showed genotoxic effect of gamma rays on DNA molecule of peripheral blood human lym- phocytes in vitro.…”
Section: Comet Assay and Fpg-modified Comet Assaymentioning
confidence: 99%
“…In previous studies, gamma radiation has diverse effects on proliferation, DNA repair, release of cytokines and etc. in in vitro cellular as well as in vivo models [16][17][18][19][20] . Especially, high gamma radiation increases calcium-induced keratinocyte HaCaT cells were exposed to gamma radiation and control cells were untreated.…”
Section: Resultsmentioning
confidence: 99%
“…6,[14][15][16] Their results indicated that 125 I in close proximity to DNA reduced the Double-Strand Breaks per decay by a direct mechanism. The extent of the damaged DNA due to irradiation is dependent on the distance between the decaying 125 I atom and the cleaved deoxyribosyl unit.…”
mentioning
confidence: 98%
“…The extent of the damaged DNA due to irradiation is dependent on the distance between the decaying 125 I atom and the cleaved deoxyribosyl unit. 15,16 The Auger electrons emitted from 125 I deposit their all energy within several nanometers distance and their simultaneous action produces a considerable amount of damage to biomolecules, compared with that of an a particle. 17 The Auger cascade would only produce disruption of *5 base pairs on both sides of the decaying atom if the 125 I was affixed to a base that was incorporated into a duplex deoxyribonucleic oligonucleotide.…”
mentioning
confidence: 99%