Effects of low-dose ionizing radiation on genomic instability in interventional radiology workers

Kochanova, Dominika; Gulati, Sachin; Durdik, Matus; Jakl, Lukas; Kosik, Pavol; Skorvaga, Milan; Vrobelova, Katarina; Vigasova, Katarina; Markova, Eva; Salat, Dusan; Klepanec, Andrej; Belyaev, Igor

doi:10.1038/s41598-023-42139-5

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…In addition, the results of a study on radiologists demonstrated that these individuals suffered from genomic instability, chromosomal aberrations, and genetic mutations in the DNA molecule in the long term (15).…”

Section: Discussionmentioning

confidence: 99%

Comparing the Levels of Total Plasma Antioxidant Capacity in Hamadan Hospitals Between Radiographic Technologists and Non-radiographic Technologists

Safari,

Maaboodi,

Zarezadei

2024

Avicenna J Care Health Oper Room

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Background: Changes in the plasma total antioxidant capacity (TAC) are considered an important prognosis in the formation and progression of many atherogenic diseases, the TAC, carcinogenesis, and inflammation. In this study, plasma TAC values were measured in radiographic and non-radiographic technologists. Methods: The present study was conducted on 75 people exposed to radiation in the radiology centers of Hamadan hospitals and 75 non-radioactive people working in the other non-radiology departments of Hamadan hospitals. The people in the studied population were matched in terms of age and gender. After preparing their blood samples, the plasma of each was separated, and then, the plasma TAC values were measured by the calorimetric method. Results: The results showed that the antioxidant capacity of total plasma was lower in radiographic technologists compared to individuals working in other non-radiology departments, so that in the two studied groups, it was 5.32±0.66 and 6.70±0.95 μmol/L, respectively (P<0.0001). Conclusion: The findings of this research revealed that the plasma TAC was lower in radiographic technologists than in individuals working in other non-radiology departments. Therefore, people exposed to radiation are more exposed to risks caused by changes in plasma TAC, and the use of antioxidant substances is recommended for these people.

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Section: Discussionmentioning

confidence: 99%

Comparing the Levels of Total Plasma Antioxidant Capacity in Hamadan Hospitals Between Radiographic Technologists and Non-radiographic Technologists

Safari,

Maaboodi,

Zarezadei

2024

Avicenna J Care Health Oper Room

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“…Image acquisition utilized a high-resolution monochrome megapixel charge-coupled device (CCD) camera with a resolution of 1280 × 1024 pixels. The microscope employed was connected to a motorized microscope Axioplan 2 Imaging E MOT [23,27].…”

Section: Automated High-throughput Scoring Of DC and Mnmentioning

confidence: 99%

Lab to Emergency: Establishment and validation of automated method for rapid biodosimetry

Vijayalakshmi,

Chaurasia,

Nair

et al. 2024

Preprint

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In inadvertent radiation exposure scenarios, accurate measurement of absorbed dose by biodosimetric techniques is crucial, especially when physical dosimetry is unavailable or in dispute. Chromosomal aberrations like dicentric (DC) and micronuclei (MN) are widely used for biodosimetry, with the former being the gold standard for individual dose assessment. However, both methods are labour-intensive requiring skilled analysis. This study aims to assess and compare the frequency and accuracy of DC and MN scoring through manual and automated methods. It investigates the establishment and validation of dose-response curves, in the dose range of 0-5 Gy, for 60Co-γ-ray-induced DC and MN using peripheral blood samples from three human volunteers. Statistical analysis confirmed dose-dependent increases in aberration frequencies, with Poisson distribution validation for all dose points. The manual and automated scoring methods yielded notable differences in linear and quadratic coefficients. Correlation analyses demonstrated substantial agreement between manual and automated scoring methods, particularly for MN (R2= 0.98). Towards validation, 16 dose-blinded samples were analysed for both endpoints using manual and automated scoring methods. Results yielded a close match between estimated and delivered doses, particularly evident with automated scoring (of both DC and MN) displaying superior accuracy for most of the doses. Notably, the variation was minimal, with -1.96% for DC and 2.85% for MN at 0.5 and 4 Gy, respectively. Automated scoring was approximately 15-20 times faster than manual scoring, suggestive of a faster practical option, especially in emergency scenarios such as criticality accidents and radiological emergencies, thus facilitating speedy triage and medical decisions.

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Gender differences in the diagnostic efficacy of coronary CTA: Overutilization of coronary CTA in pre- and perimenopausal females?

Feuchtner,

Lacaita,

Barbieri

et al. 2024

International Journal of Cardiology

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Effects of low-dose ionizing radiation on genomic instability in interventional radiology workers

Cited by 5 publications

References 51 publications

Comparing the Levels of Total Plasma Antioxidant Capacity in Hamadan Hospitals Between Radiographic Technologists and Non-radiographic Technologists

Comparing the Levels of Total Plasma Antioxidant Capacity in Hamadan Hospitals Between Radiographic Technologists and Non-radiographic Technologists

Lab to Emergency: Establishment and validation of automated method for rapid biodosimetry

Gender differences in the diagnostic efficacy of coronary CTA: Overutilization of coronary CTA in pre- and perimenopausal females?

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