2011
DOI: 10.1016/j.ijom.2011.07.100
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Effects of low dose ketamine combined with local anesthetic on postoperative complications after impacted third molar surgery

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“…[ 14 ] and Yildrim et al . [ 15 ] Explanation for decreased swelling after the administration of ketamine was given by Mazar et al .,[ 16 ] and he stated that the anti-inflammatory effects of ketamine were mediated by the release of adenosine and adenosine through A2AR reduces the systemic inflammatory response by the inhibition of secretion of pro-inflammatory cytokines as well as leukocyte activation and recruitment. Postoperative trismus was assessed in both the groups, before the surgery and postoperatively on 1 st , 3 rd , 7 th day, results suggest that trismus was significantly reduced on 3 rd day (39.06 ± 5.01) and 7 th day (40.18 ± 4.24) in group LAK as compared to group LAA [ Table 4 ].…”
Section: Discussionmentioning
confidence: 99%
“…[ 14 ] and Yildrim et al . [ 15 ] Explanation for decreased swelling after the administration of ketamine was given by Mazar et al .,[ 16 ] and he stated that the anti-inflammatory effects of ketamine were mediated by the release of adenosine and adenosine through A2AR reduces the systemic inflammatory response by the inhibition of secretion of pro-inflammatory cytokines as well as leukocyte activation and recruitment. Postoperative trismus was assessed in both the groups, before the surgery and postoperatively on 1 st , 3 rd , 7 th day, results suggest that trismus was significantly reduced on 3 rd day (39.06 ± 5.01) and 7 th day (40.18 ± 4.24) in group LAK as compared to group LAA [ Table 4 ].…”
Section: Discussionmentioning
confidence: 99%
“…2 Many therapeutic protocols have been designed to improve the postoperative comfort of the patient including different kind of flaps, 4 draining of wounds, 5 piezoelectric surgery, 6 postoperative extraoral and intraoral low level laser therapy, 7 the postoperative application of ice pack, 8 and postoperative systemic or topical application of various analgesics, muscle-relaxants, corticosteroids, anti-inflammatory drugs and antibiotics to suppress the mediators of inflammation which will reduce fluid transudation and will lessen edema. [9][10][11] Ketamine is a phencyclidine derivative that induces a state of dissociative anesthesia. 1 This is characterized as 'dissociation' between the thalamocortical and limbic systems, producing a cataleptic state during which the patient may appear awake but does not respond to commands.…”
Section: 5005/jp-journals-10024-1788mentioning
confidence: 99%