Effects of low‐dose mirtazapine on driving performance in healthy volunteers

Iwamoto, Kunihiro; Kawano, Naoki; Sasada, Kazumi; Kohmura, Kunihiro; Yamamoto, Maeri; Ebe, Koji; Noda, Yukihiro; Ozaki, Norio

doi:10.1002/hup.2327

Cited by 12 publications

(19 citation statements)

References 31 publications

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“…Furthermore, our study also showed that a daily dosing regimen of MIR at 15 mg/kg or more decreased spontaneous locomotor activity within 10 minutes of administration, with a gradual decrease in sedative effects, 10,15 while balance and motor coordination were unaffected. Conversely, TRZ impaired motor activity, balance, and motor coordination quickly (within 5 minutes) and for up to 60 minutes.…”

Section: Experiments 2: Effect Of Chronic Mir Dosing On Sedationsupporting

confidence: 66%

“…10 Additionally, Poyurovsky et al 15 have reported that MIR given in doses of 15 mg/kg is well tolerated and causes only mild and transient sedation.…”

Section: Experiments 1: Effect Of Acute Mir Dosing On Sedationmentioning

confidence: 99%

“…8,9 Several studies suggest that MIR-induced sedation can be mainly attributed to its potent blockade of H1Rs. 10,11 Nevertheless, some authors consider that sedative antidepressants like MIR may be a useful treatment option for some patients with agitation or insomnia. 12,13 Clinical studies have shown that a lower initial dose of MIR (i.e., p15 mg/kg) provides potent histaminergic blockade that induces clear sedation and sleepiness, [14][15][16] whereas a higher initial MIR dose (i.e., X 30 mg/kg) is associated with decreased sedative antihistaminergic activity due to increased noradrenergic transmission.…”

Section: Introductionmentioning

confidence: 99%

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Chronic dosing with mirtazapine does not produce sedation in rats

Salazar-Juárez

Barbosa-Méndez

Merino-Reyes

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: Sedation/somnolence are major side effects of pharmacotherapies for depression, and negatively affect long-term treatment compliance in depressed patients. Use of mirtazapine (MIR), an atypical antidepressant approved for the treatment of moderate to severe depression with comorbid anxiety disorders, is associated with significant sedation/somnolence, especially in short-term therapy. Nonetheless, studies with human subjects suggest that MIR-induced sedation is transient, especially when high and repeated doses are used. The purpose of this study was to explore the effects of acute and chronic administration of different doses of MIR on sedation in the rat. Methods: Assessment of sedation was carried out behaviorally using the rotarod, spontaneous locomotor activity, and fixed-bar tests. Results: A 15-mg/kg dose of MIR induced sedative effects for up to 60 minutes, whereas 30 mg/kg or more produced sedation within minutes and only in the first few days of administration. Conclusion: These results suggest that 30 mg/kg is a safe, well-tolerated dose of MIR which generates only temporary sedative effects.

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Section: Experiments 2: Effect Of Chronic Mir Dosing On Sedationsupporting

confidence: 66%

“…10 Additionally, Poyurovsky et al 15 have reported that MIR given in doses of 15 mg/kg is well tolerated and causes only mild and transient sedation.…”

Section: Experiments 1: Effect Of Acute Mir Dosing On Sedationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic dosing with mirtazapine does not produce sedation in rats

Salazar-Juárez

Barbosa-Méndez

Merino-Reyes

et al. 2017

Rev. Bras. Psiquiatr.

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“…The magnitude of impairment reached a clinically relevant level, as the observed SDLP increment relative to placebo was comparable to that seen with a BAC of 0.05%. Consistently, after mirtazapine 15 and 30 mg, driving impairment was also found in the driving simulator studies Iwamoto et al, 2013). After 1 or 2 weeks of daily treatment with mirtazapine, driving impairment was much less pronounced, and it differed between studies whether significant differences from placebo were found.…”

Section: Discussionsupporting

confidence: 51%

Mirtazapine as positive control drug in studies examining the effects of antidepressants on driving ability

Verster

Loo

Roth

2015

European Journal of Pharmacology

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“…There are currently 36 types of confirmed DS . As each research group uses a DS for a specific purpose, there is no unified scenario (e.g., highway, urban roads).…”

Section: Resultsmentioning

confidence: 99%

Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review

Iwata

Iwamoto

Kawano

et al. 2018

Psychiatry Clin Neurosci

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Although automobile driving is necessary for many people, including patients with mental disorders, the influence of psychotropic drugs on driving performance remains unclear and requires scientific verification. Therefore, the objective of this study was to conduct a review of the literature in order to aid the development of a valid evaluation method regarding the influence of medication on driving performance. We conducted a literature search using two sets of terms on PubMed. One set was related to psychotropic drugs, and the other to driving tests. We excluded reviews and case studies and added literature found on other sites. A total of 121 relevant reports were found. The experiments were roughly divided into on-the-road tests (ORT) and driving simulators (DS). Although highway driving tests in ORT are most often used to evaluate driving performance, DS are becoming increasingly common because of their safety and low cost. The validity of evaluation methods for alcohol should be verified; however, we found that there were few validated tests, especially for DS. The scenarios and measurement indices of each DS were different, which makes it difficult to compare the results of DS studies directly. No evaluation indices, except for SD of lateral position, were sufficiently validated. Although highway ORT are the gold standard, DS were shown to have an increasing role in evaluating driving performance. The reliability of DS needs to be established, as does their validation with alcohol in order to accumulate more high-quality evidence.

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Effects of low‐dose mirtazapine on driving performance in healthy volunteers

Cited by 12 publications

References 31 publications

Chronic dosing with mirtazapine does not produce sedation in rats

Chronic dosing with mirtazapine does not produce sedation in rats

Mirtazapine as positive control drug in studies examining the effects of antidepressants on driving ability

Evaluation method regarding the effect of psychotropic drugs on driving performance: A literature review

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