Effects of low dose X‐ray irradiation on porcine articular cartilage explants

Lindburg, Carl Alexander; Willey, Jeffrey S.; Dean, Delphine

doi:10.1002/jor.22406

Cited by 21 publications

(25 citation statements)

References 34 publications

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“…The effects of radiation on cartilage may be concealed by the considerable delay existing between radiation therapy and joint symptoms [24,31]. Compressive modulus values for equine dorsal cartilage are similar to previous reported E. Cicek values [8,18,20,21,23].…”

Section: Resultssupporting

confidence: 84%

“…Ionizing radiation is known to lower proteoglycan content and compressive stiffness [8,[22][23][24][25]. Previous studies display that reactive oxygen radicals induced by ionizing radiation may be responsible for the degradation of the physiologically important glycosaminoglycan hyaluronan [10,26,27].…”

Section: Resultsmentioning

confidence: 99%

“…But articular cartilage from adult humans or large animal species seems to degrade after exposure [24,29].…”

Section: Resultsmentioning

confidence: 99%

“…As the radiation evidently damages cartilage matrix metabolism, a reduction in compressive modulus of the radiation exposed cartilage can be theorized [24].…”

Section: Resultsmentioning

confidence: 99%

“…Joint injury is considered as a late consequence of ionizing radiation exposure [24], although there is not much information regarding the early effects on articular cartilage metabolism or mechanical properties. The effects of radiation on cartilage may be concealed by the considerable delay existing between radiation therapy and joint symptoms [24,31].…”

Section: Resultsmentioning

confidence: 99%

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Effect of X-ray Irradiation on Articular Cartilage Mechanical Properties

Çiçek

2016

Acta Phys. Pol. A

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A load bearing tissue found at the ends of articulating bones, the articular cartilage provides low friction surfaces for efficient movement. Its mechanical properties are determined by the structure and composition of type II collagen, proteoglycans and interstitial fluid. This work investigates the effects of X-ray irradiation, previously shown to affect the biological properties of the articular tissue, on mechanical properties of articular cartilage using polarized light microscope for imaging and compressive modulus test applied to articular cartilage to determine the effects of the ionizing radiation on mechanical properties. According to the test results, the relaxation time is significantly longer in control than X-ray exposed samples, while the force is much higher showing that the X-ray irradiation causes the reduction in the stiffness of articular cartilage.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

“…But articular cartilage from adult humans or large animal species seems to degrade after exposure [24,29].…”

Section: Resultsmentioning

confidence: 99%

“…As the radiation evidently damages cartilage matrix metabolism, a reduction in compressive modulus of the radiation exposed cartilage can be theorized [24].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of X-ray Irradiation on Articular Cartilage Mechanical Properties

Çiçek

2016

Acta Phys. Pol. A

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Nanosonosensitization by Using Copper–Cysteamine Nanoparticles Augmented Sonodynamic Cancer Treatment

Wang

et al. 2018

Part & Part Syst Charact

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Sonodynamic therapy (SDT), as a newly emerging and promising modality for cancer treatment, has been extensively investigated but with limited therapeutic outcome because of the absence of highly efficient sonosensitizer. Copper–cysteamine (Cu–Cy), as a new sensitizer, has been reported for oxidative therapy which can be activated with light, X‐ray, or microwave. Herein, for the first time, Cu–Cy nanoparticles are reported as new sonosensitizers for SDT on breast cancer treatment. Upon exposure of Cu–Cy nanoparticles to ultrasound, a large quantity of reactive oxygen species (ROS) are generated for cancer cell destruction with a high SDT efficiency to induce cell apoptosis and necrosis as observed in vitro. In vivo animal studies show a significant inhibition of tumor growth for the xenografts of 4T1 cancer cells with the combination of 0.75 mg kg−1 Cu–Cy and ultrasound. Overall, the preliminary results show that Cu–Cy nanoparticles can significantly augment the levels of ROS induced by ultrasound, demonstrating Cu–Cy is a new kind of efficient sonosensitzers for SDT applications. Such therapeutic platform by integrating a noninvasive, highly safe, deep‐penetration ultrasound modality. and quickly developed versatile nanosensitizers for tumor eradication will facilitate SDT future clinical translation.

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