1994
DOI: 10.1097/00004850-199400920-00003
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Effects of low doses of lorazepam on psychometric tests in healthy volunteers

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Cited by 10 publications
(3 citation statements)
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“…The tests in our study were realized after a dose of 0.5 mg of lorazepam (the daily dosage was of 0.5, 0.5, 1 mg). The results could be in line with those of studies performed in healthy young volunteers receiving low doses of lorazepam, showing an improvement in explicit episodic memory test (File et al, 1999), or on the psychomotor performance without sedation and memory impairment (Bourin et al, 1994). Lastly, effects in patients of the anxiety reduction on mnesic performances or a tolerance phenomenon after repeated intakes are to be considered (Curran, 1992).…”
Section: Discussionsupporting
confidence: 84%
“…The tests in our study were realized after a dose of 0.5 mg of lorazepam (the daily dosage was of 0.5, 0.5, 1 mg). The results could be in line with those of studies performed in healthy young volunteers receiving low doses of lorazepam, showing an improvement in explicit episodic memory test (File et al, 1999), or on the psychomotor performance without sedation and memory impairment (Bourin et al, 1994). Lastly, effects in patients of the anxiety reduction on mnesic performances or a tolerance phenomenon after repeated intakes are to be considered (Curran, 1992).…”
Section: Discussionsupporting
confidence: 84%
“…One explanation might be the paradoxical ‘psychostimulant’ effect reported by Bourin et al. [25] after low doses of lorazepam in healthy subjects.…”
Section: Discussionmentioning
confidence: 99%
“…BZD, through this disinhibitory effectiveness, may correct the dis-rupted cognitive mechanisms that underlie anxiety states. Two important main questions have to be solved with respect to this question of BZD in anxiety: the first one is to know whether the BZD doses which are active in anxious subjects differ from those which are likely to be active i n healthy volunteers [ I ] ; the second one is to compare the effects of very low dosages of BZD with higher ones, knowing that the lowest are supposed to exert anti-inhibition and promnestic effects or to improve psychomotor performance [3].…”
Section: Introductionmentioning
confidence: 99%