Effects of low humidity on the rat middle ear

Lovejoy, Hugh M.; McGuirt, W. Frederick; Ayres, Paul H.; Hayes, A. Wallace; Coggins, Christopher R. E.; Sagartz, John W.

doi:10.1288/00005537-199409000-00001

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…We have previously reported that one of these epidemiological variables, low relative humidity, does produce SOM in experimental animals: the suitability of our rat model has been verified (15 (14). ETS is extremely dilute, and it &dquo;differs both chemically and physically from the precursor sidestream smoke, presumably due to chemical and physical transformations that occur as the mixture is aged and diluted&dquo; (14).…”

Section: Introductionmentioning

confidence: 68%

Relevant Exposure to Environmental Tobacco Smoke Surrogate Does Not Produce or Modify Secretory Otitis Media in the Rat

et al. 1997

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Parental smoking is a possible risk factor in the development of secretory otitis media (SOM) in children. This experiment was designed to determine, using rats as an experimental model, whether exposures to environmental tobacco smoke (ETS) produce SOM and whether ETS exposure affects the rate of clearance of an experimentally induced effusion. Male Sprague-Dawley rats were exposed to 3 different concentrations of aged and diluted sidestream smoke, a surrogate for ETS, from 1R4F research cigarettes for 6 hr per day for 5 days. Experimental SOM was induced bilaterally in subgroups of animals from each group, by cold air exposure to the external auditory canals. Ears of rats were examined during the in-life portion of the study. Histopathologic examination of the middle ear was conducted at the termination of the 5-day period. The production of SOM was not induced by ETS exposure, nor were there differences noted between the groups in the rates of clearance of the experimentally induced SOM. Short-term exposure to ETS did not affect the acquisition or clearance of SOM in the rat.

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Section: Introductionmentioning

confidence: 68%

Relevant Exposure to Environmental Tobacco Smoke Surrogate Does Not Produce or Modify Secretory Otitis Media in the Rat

et al. 1997

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“…The resultant lower humidity in the normally moist middle ear cleft causing a mucociliary dysfunction, further predisposing the ear to infection. 13…”

Section: Perforated Tympanic Membranesmentioning

confidence: 99%

Relative humidity of the external auditory canal in normal and abnormal ears, and its pathogenic effect

Gray

Sharma

Vowler

2005

Clinical Otolaryngology

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“…Sprague-Dawley rats housed for five days in a low humidity environment (10–12%) had a higher incidence of serous effusions in the middle ear than the control group (humidity 50–55%). Nevertheless, the changes in the middle ear were temporary [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Reporting Data on Auditory Brainstem Responses (ABR) in Rats: Recommendations Based on Review of Experimental Protocols and Literature

et al. 2021

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Research in hearing science is accelerating, and a wealth of data concerning auditory brainstem responses (ABR) in various animal models is published in peer-reviewed journals every year. Recently, we reviewed studies using ABR measurements in tinnitus rat models. We found significant discrepancies in the outcomes of these studies, some due to different research approaches and others due to different methodologies. Thus, the present work aimed to collect comprehensive information on all factors influencing ABR recordings in rats and compile recommendations on ABR data reporting. A questionnaire with queries about animal husbandry, transfer, handling, and the exact test conditions before, during, and after ABR recordings was sent to 125 researchers who published the relevant studies between 2015 and 2021. Eighteen researchers provided detailed answers on factors related to ABR measurements. Based on the analysis of the returned questionnaires, we identified three domains reflecting animal-, equipment-, and experiment-dependent factors that might influence the ABR outcome, thus requiring reporting in published research. The analysis of survey results led to the compilation of recommendations for reporting ABR outcomes supported by a literature review. Following these recommendations should facilitate comparative and meta-analyses of ABR results provided by various research groups.

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Effects of low humidity on the rat middle ear

Cited by 6 publications

References 20 publications

Relevant Exposure to Environmental Tobacco Smoke Surrogate Does Not Produce or Modify Secretory Otitis Media in the Rat

Relevant Exposure to Environmental Tobacco Smoke Surrogate Does Not Produce or Modify Secretory Otitis Media in the Rat

Relative humidity of the external auditory canal in normal and abnormal ears, and its pathogenic effect

Reporting Data on Auditory Brainstem Responses (ABR) in Rats: Recommendations Based on Review of Experimental Protocols and Literature

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