Effects of low-level laser therapy and platelet concentrate on bone repair: Histological, histomorphometric, immunohistochemical, and radiographic study

Jonasson, Thiago Hoffman; Zancan, Rafael; Azevedo, Lucas de Oliveira; Fonseca, Ana Glória; Silva, Marcela Claudino da; Giovanini, Allan Fernando; Zielak, João César; Araújo, Maria Christina Barbosa de

doi:10.1016/j.jcms.2017.08.008

Cited by 21 publications

(14 citation statements)

References 37 publications

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“…The similar compressive strengths could avoid the stress shielding between implants and host bone, thus promoting endochondral and intramembranous bone formation 30 . During the degradation of the scaffolds in SBF, hydroxyapatite formed on the BGC surface, suggesting favorable bioactivity of the scaffolds 26,31 . BMSCs were cultured on the scaffolds and showed proliferation on the scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Magnesium-alloy rods reinforced bioglass bone cement composite scaffolds with cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone in vivo regeneration

Duan

Cao

Wang

et al. 2020

Sci Rep

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Various therapeutic platforms have been developed for repairing bone defects. However, scaffolds possess both cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone defects repair is still challenging in the clinic. In this study, inspired by the structure of the ferroconcrete, a high-strength bifunctional scaffold has been developed by combining surface-modified magnesium alloy as the internal load-bearing skeleton and bioglass-magnesium phosphate bone cement as the osteoconductive matrix. The scaffold combines the high mechanical strength and controllable biodegradability of surface-modified magnesium alloy with the excellent biocompatibility and osteoconductivity of bioglass-magnesium phosphate bone cement, thus providing support for load-bearing bone defects and subsequently bone regeneration. The scaffolds generate hydroxyapatite (HA) during the degrading in simulated body fluid (SBF), with the strength of the scaffold decreasing from 180 to 100 MPa in 6 weeks, which is still sufficient for load-bearing bone. Moreover, the scaffolds showed excellent osteoconductivity in vitro and in vivo. In a New Zealand White Rabbit radius defect model, the scaffolds degrade gradually and are replaced by highly matured new bone tissues, as assessed by image-based analyses (X-ray and Micro-CT) and histological analyses. The bone formation-related proteins such as BMP2, COL1a1 and OCN, all showed increased expression.

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Section: Discussionmentioning

confidence: 99%

Magnesium-alloy rods reinforced bioglass bone cement composite scaffolds with cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone in vivo regeneration

Duan

Cao

Wang

et al. 2020

Sci Rep

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“…vitro study analysis [25]. Eight studies were excluded as they were based on utilization of autogenous bone grafts for bone repair and regeneration [24,27,[36][37][38][39][40][41] (interreviewer agreement, κ = 0.94). Thus, out of the fifty-three full text articles, fifteen articles were excluded due to the above mentioned reasons and 38 articles were included and analyzed in the present systematic review .…”

Section: Study Selectionmentioning

confidence: 99%

Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies

Hanna

Dalvi

Amaroli

et al. 2020

Journal of Biophotonics

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A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or without biomaterials is unclear. This systematic review (PROSPERO, ref. CRD 42019148959) aimed to critically appraise animal in vivo published data and present the efficacy of PBMT and its potential synergistic effects on grafted bone defects. MEDLINE, CCCT, Scopus, Science Direct, Google Scholar, EMBASE, EBSCO were searched, utilizing the following keywords: bone repair; low-level laser therapy; LLLT; light emitting diode; LEDs; photobiomodulation therapy; in vivo animal studies, bone substitutes, to identify studies between 1994 and 2019. After applying the eligibility criteria, 38 papers included where the results reported according to "PRISMA." The results revealed insufficient and incomplete PBM parameters, however, the outcomes with or without biomaterials have positive effects on bone healing. In conclusion, in vivo animal studies with a standardized protocol to elucidate the effects of PBMT on biomaterials are required initially prior to clinical studies.

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“…Extracts were administered to treat the fractured bone of the experimental animals for 8 weeks. The progression of bone healing has been assessed for every week using X-ray radiography and compared the result with control and standard [40].…”

Section: Radiographical Parametermentioning

confidence: 99%

Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats

Ramachandran¹,

Fadhil²,

Gopi³

et al. 2021

Beni-Suef Univ J Basic Appl Sci

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Background The object of the present study is to evaluate the effect of alcoholic extracts of Cissus quadrangularis (CQ), Cryptolepis buchanani (CB), and Sardinella longiceps (SL) either alone or in the combination (100 mg/kg) in the management of femur bone healing of Wistar albino rats for 8 weeks. After the period of treatment, femur bones were examined by using biochemical, radiographical, and histopathological studies. Result Biochemical evaluation results reveal that there is a steep increase of serum calcium level in the experimental animals during the entire period of treatment which led to an adequate supply of serum calcium to the fractured bone for healing and increases the thickness of the femur bones soon compared to control group. It had been estimated by a calibrated ocular micrometer. Radiographical images of the bones also disclose that the complete bridging of fractured bone occurred in the experimental animals after the treatment of natural compound extracts. In addition to that, all the organs of animals were safe in the experimental animals during the entire study. Conclusion The present study strongly recommended that these ethanolic extracts (CQCBSL) either alone or in the combination restoring the strength of the bone and reduced bone repairing period due to the rich content of calcium and other natural phytochemicals presents with them. Graphical abstract

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Effects of low-level laser therapy and platelet concentrate on bone repair: Histological, histomorphometric, immunohistochemical, and radiographic study

Cited by 21 publications

References 37 publications

Magnesium-alloy rods reinforced bioglass bone cement composite scaffolds with cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone in vivo regeneration

Magnesium-alloy rods reinforced bioglass bone cement composite scaffolds with cortical bone-matching mechanical properties and excellent osteoconductivity for load-bearing bone in vivo regeneration

Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies

Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats

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