Effects of low-level laser therapy on wound healing

Andrade, Fabiana do Socorro da Silva Dias; Clark, Alexander M.; Ferreira, Manoel Luiz

doi:10.1590/s0100-69912014000200010

Cited by 99 publications

(72 citation statements)

References 24 publications

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“…Another study 7 showed that the LPL (InGaAlP, 660 nm, According to literature, doses ranging from 3-6 J/cm 2 appear to be more effective, while doses higher than 10 J/cm 2 are associated with harmful effects 13 , nevertheless, it was proved that a daily dose of 30 J/cm 2 and power density at 25 mW/cm 2 of 670 nm laser, continuous mode, was able to shorten the inflammation without compromising the metabolism of fibroblasts, positively influencing all the phases of wound cicatrization in the skin of 49 rats, which produced two parallel wounds on the back, where one served as a control and the other was exposed to laser irradiation 21 .…”

Section: Discussionmentioning

confidence: 99%

“…In the last years, several studies have shown the benefits of the extensive use of the LPL in situations such as the treatment of soft tissue injuries, joint diseases, open wounds, pressure ulcers, among others [11][12][13][14] . The AlGaInP laser (660 nm) is a therapeutic light of the electromagnetic spectrum in the red line, whose irradiation in injured tissues triggers a series of physiological effects necessary for the process of wound cicatrization and repair at tissue and organic levels by means of the photobiomodulation process, in addition to causing therapeutic effects, such as: local analgesia, edema reduction and anti-inflammatory action 11,15 .…”

Section: Led (Light Emitting Diode) and The High Frequency Generatormentioning

confidence: 99%

“…Studies show that the LPL 7,12,13,[19][20][21] , as well as HF 9,16 , accelerate the tissue repair process for wounds, after incisional lesion, being relevant in the treatment of skin disorders, once the AlGaInP laser reduces the inflammatory reaction and provides better quality and greater speed in the repair process of soft tissue 11,15 , while the HF can intervene in the oxidoreduction balance with germicide, bactericide and antiseptic properties in the cicatrization process 9,16 . Given this, the goal was to have a macroscopic, histological and histomorphometric assessment of the process for cutaneous wound cicatrization in mice, by using AlGaInP Laser therapy compared to treatment with HF.…”

Section: Led (Light Emitting Diode) and The High Frequency Generatormentioning

confidence: 99%

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Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Sousa¹,

Filho

Nicolau

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate in a macroscopic, histological and histomorphometric manner the healing process of cutaneous wounds in mice. METHODS: RESULTS:It was observed that in the acute phase the AlGaInP Laser at 5 J/cm 2 provided a greater stimulus to healing, and both lasers were effective in the remodeling phase. CONCLUSION:The AlGaInP lasers from 5 J/cm 2 to 8 J/cm 2 showed better biomodulatory results in the acute and remodeling phases respectively, however, the HF was less effective than the laser, providing significant benefits only in the acute phase of tissue repair.

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Section: Discussionmentioning

confidence: 99%

Section: Led (Light Emitting Diode) and The High Frequency Generatormentioning

confidence: 99%

Section: Led (Light Emitting Diode) and The High Frequency Generatormentioning

confidence: 99%

See 1 more Smart Citation

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Sousa¹,

Filho

Nicolau

et al. 2015

Acta Cir. Bras.

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“…Studies using LLLT showed no similarities due to changes in methodology due to differences in implemented radiation 7 .…”

Section: Discussionmentioning

confidence: 99%

“…One of the latest technologies is the low-level laser, which has characteristics to induce cell proliferation, increase the ATP synthesis, increase tensile strength of scar tissue and promoting the reduction of pain and trauma during dressing change [4][5][6][7][8] . There are currently promising research aiming to substantiate the benefits of laser therapy as well as the occlusive dressing in moist environment in the systemic healing process of a wound 4,6,7,9,10 . Thus the present study evaluated the effects of low-level laser associated with the hydrocolloid dressing on wound tissue repair in rats, by assessing the diameter of the wound and the histological analysis of healing.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the healing process of the wounds occurring in rats using lasertherapy in association with hydrocolloid

Martins

Torres²,

Santos³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate wound healing in rats by using low-level laser therapy (LLLT) associated with hydrocolloid occlusive dressing. METHODS:Forty male, adult, Wistar rats were used, distributed into four groups: LG (received 2 J/cm² of laser therapy); HG (treated with hydrocolloid); LHG (treated with 2 J/cm² of laser therapy and hydrocolloid); and the CG (treated with 1 mL of 0.9% saline).The wound was evaluated at pre-determined periods 3rd and 7th days, considering the macroscopic and histological parameters (inflammatory cells, capillary neoformation, fibroblasts, collagen formation and reepithelialization). RESULTS:The LG group at seven days showed increased collagen formation, the LHG group at 3 days showed mild collagen formation. The HG group and the CG at 7 days showed complete reepithelialization. CONCLUSION:Low-level laser therapy as well as the hydrocolloid dressing have favored the wound-healing process in rats.

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Photobiomodulation Response From 660 nm is Different and More Durable Than That From 980 nm

et al. 2021

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Background and Objectives: Photobiomodulation (PBM) therapy uses light at various wavelengths to stimulate wound healing, grow hair, relieve pain, and more-but there is no consensus about optimal wavelengths or dosimetry. PBM therapy works through putative, wavelength-dependent mechanisms including direct stimulation of mitochondrial respiration, and/or activation of transmembrane signaling channels by changes in water activity. A common wavelength used in the visible red spectrum is~660 nm, whereas recently~980 nm is being explored and both have been proposed to work via different mechanisms. We aimed to gain more insight into identifying treatment parameters and the putative mechanisms involved. Study Design/Materials and Methods: Fluenceresponse curves were measured in cultured keratinocytes and fibroblasts exposed to 660 or 980 nm from LED sources. Metabolic activity was assessed using the MTT assay for reductases. ATP production, a major event triggered by PBM therapy, was assessed using a luminescence assay. To measure the role of mitochondria, we used an ELISA to measure COX-1 and SDH-A protein levels. The respective contributions of cytochrome c oxidase and ATP synthase to the PBM effects were gauged using specific inhibitors. Results: Keratinocytes and fibroblasts responded differently to exposures at 660 nm (red) and 980 nm (NIR). Although 980 nm required much lower fluence for cell stimulation, the resulting increase in ATP levels was short-term, whereas 660 nm stimulation elevated ATP levels for at least 24 hours. COX-1 protein levels were increased following 660 nm treatment but were unaffected by 980 nm. In fibroblasts, SDH-A levels were affected by both wavelengths, whereas in keratinocytes only 660 nm light impacted SDH-A levels. Inhibition of ATP synthase nearly completely abolished the effects of both wavelengths on ATP synthesis. Interestingly, inhibiting cytochrome c oxidase did not prevent the rise in ATP levels in response to PBM treatment. Conclusion:To the best of our knowledge, this is the first demonstration of differing kinetics in response to PBM therapy at red versus NIR wavelength. We also found celltype-specific differences in PBM therapy response to the two wavelengths studied. These findings confirm that different response pathways are involved after 660 and 980 nm exposures and suggest that 660 nm causes a more durable response.

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Effects of low-level laser therapy on wound healing

Abstract: Low-level laser can be safely applied to accelerate the resolution of cutaneous wounds, although this fact is closely related to the election of parameters such as dose, time of exposure and wavelength.

Cited by 99 publications

References 24 publications

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Action of AlGaInP laser and high frequency generator in cutaneous wound healing. A comparative study

Analysis of the healing process of the wounds occurring in rats using lasertherapy in association with hydrocolloid

Photobiomodulation Response From 660 nm is Different and More Durable Than That From 980 nm

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