Effects of low power laser irradiation on bone healing in animals: a meta-analysis

Tajali, Siamak Bashardoust; MacDermid, Joy C.; Houghton, Pamela E.; Grewal, Ruby

doi:10.1186/1749-799x-5-1

Cited by 79 publications

(41 citation statements)

References 33 publications

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“…Previous studies have demonstrated the beneficial effects of LLLT on bone repair in experimental models of DM 12,13 . However, many other controversial data have been reported in the literature concerning the modulatory effect of LLLT on bone healing in diabetic animals, likely as a result of the variety of threshold parameters for energy density and intensity, including the irradiation time and the irradiation mode, used in the experiments 14,15 . Therefore, the purpose of this study was to assess the effect of a protocol of low-level laser therapy using diode GaAlAs laser on the bone repair in alloxan-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

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Brazil. Design of the study, histological examinations, manuscript writing, supervised all phases of the study. ABSTRACT PURPOSE:To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS:Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS:Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05). CONCLUSION:Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxaninduced diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Nascimento

Almeida

Cunha³

et al. 2015

Acta Cir. Bras.

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“…The graded structure of the enthesis appears to be optimized to achieve an effective load transfer (Liu et al 2012; Genin et al 2009). However, this optimized interface is not re-formed after injury, leading to poor healing outcomes, presumably due to concentrations of stress at the interface (Lui et al 2010; Harryman et al 1991; Galatz et al 2004). Our paper examines mechanical loading on the developing enthesis structure over time, offering an understanding of mechanical factors that may be important for the development, homeostasis, and healing of a functional enthesis.…”

Section: Introductionmentioning

confidence: 99%

Stress amplification during development of the tendon-to-bone attachment

Liu

Schwartz

Birman

et al. 2013

Biomech Model Mechanobiol

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Mechanical stress is necessary to sustain the mineral content of bone in adults. However, in a developing neonatal mouse, the mineralization of soft tissues progresses despite greatly reduced average mechanical stresses. In adults, these reduced loads would likely lead to bone loss. Although biochemical factors may partly explain these different responses, it is unclear how mineralization is initiated in low load environments. We present here the effect of morphometric data and initial modeling supporting a hypothesis that mechanical factors across several length scales amplify stresses, and we suggest that these stresses are of a level adequate to contribute to mechanical signaling for initiation of mineralization at the developing tendon-to-bone enthesis. A mineral gradient is evident across the insertion from the onset of mineralization. This grading maintains a constant size from early postnatal time points to adulthood. At the tissue level, this grading contributes to reduced stresses in an adult animal and to a minor elevation of stresses in a neonatal animal. At the cellular level, stress concentrations around mineralizing chondrocytes are enhanced in neonatal animals compared to adult animals. The enhancement of stresses around cells at early timepoints may serve to amplify and transduce low loads in order to initiate mineralization.

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“…Low power LASER devices have little to no thermal effects and are used to treat an array of musculoskeletal conditions to decrease pain, inflammation and soft tissue scars, and to promote fracture healing [34, 43-45]. Three main types of LASER are used clinically: helium-neon (HeNe wavelength 632.8nm, tissue penetration 0.8mm), the gallium-arsenide (GaAs 904nm, penetrating 5cm) and the gallium-aluminum-arsenide (GaAlAs 830nm, penetrating 2-3cm) [34, 43].…”

Section: Lasermentioning

confidence: 99%

An ICON Overview on Physical Modalities for Neck Pain and Associated Disorders

Graham

Gross²,

Carlesso³

et al. 2013

TOORTHJ

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Introduction: Neck pain is common, can be disabling and is costly to society. Physical modalities are often included in neck rehabilitation programs. Interventions may include thermal, electrotherapy, ultrasound, mechanical traction, laser and acupuncture. Definitive knowledge regarding optimal modalities and dosage for neck pain management is limited.Purpose: To systematically review existing literature to establish the evidence-base for recommendations on physical modalities for acute to chronic neck pain.Methods:A comprehensive computerized and manual search strategy from January 2000 to July 2012, systematic review methodological quality assessment using AMSTAR, qualitative assessment using a GRADE approach and recommendation presentation was included. Systematic or meta-analyses of studies evaluating physical modalities were eligible. Independent assessment by at least two review team members was conducted. Data extraction was performed by one reviewer and checked by a second. Disagreements were resolved by consensus.Results:Of 103 reviews eligible, 20 were included and 83 were excluded. Short term pain relief - Moderate evidence of benefit: acupuncture, intermittent traction and laser were shown to be better than placebo for chronic neck pain. Moderate evidence of no benefit: pulsed ultrasound, infrared light or continuous traction was no better than placebo for acute whiplash associated disorder, chronic myofascial neck pain or subacute to chronic neck pain. There was no added benefit when hot packs were combined with mobilization, manipulation or electrical muscle stimulation for chronic neck pain, function or patient satisfaction at six month follow-up.Conclusions:The current state of the evidence favours acupuncture, laser and intermittent traction for chronic neck pain. Some electrotherapies show little benefit for chronic neck pain. Consistent dosage, improved design and long term follow-up continue to be the recommendations for future research.

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Effects of low power laser irradiation on bone healing in animals: a meta-analysis

Cited by 79 publications

References 33 publications

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Stress amplification during development of the tendon-to-bone attachment

An ICON Overview on Physical Modalities for Neck Pain and Associated Disorders

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