Effects of low stress during pregnancy on certain parameters of the offspring

Téllez-Rojo, Martha M.; Marín, B; Menéndez-Patterson, A

doi:10.1016/0031-9384(85)90010-1

Cited by 32 publications

(13 citation statements)

References 19 publications

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“…Many studies report lower birth weights of the pups following prenatal stress , though some studies used for instance immobilization stress throughout pregnancy and found no effect on birth weight (e.g., Rojo, Marin, & Menendez-Patterson, 1985) or found even an increase in birth weight after crowding stress in the last week of pregnancy (Dahlof et al, 1978). Early motor development appears to be sensitive to maternal stress as well.…”

Section: Effects Of Prenatal Stress On Behavior Of Rodent Offspringmentioning

confidence: 94%

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Huizink¹,

Mulder²,

Buitelaar³

2004

Psychological Bulletin

426

294

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This review focuses on prenatal stress as a risk factor for psychopathology. Evidence from animal studies is summarized, and the relevance of prenatal stress models in animals for human studies is discussed. In the offspring of prenatally stressed animals, overactivity and impaired negative feedback regulation of the hypothalamic-pituitary-adrenal axis are consistent findings and may reflect a pathophysiological mechanism involved in the development of psychopathology. Reduced activity of the opioid GABA/benzodiazepine, serotonin, and dopamine systems and increased activity of the sympathico-adrenal system have been found as well. These alterations have been linked to a diverse spectrum of psychopathology. Therefore, the evidence supports the view that exposure to prenatal stress may result in a general susceptibility to psychopathology, rather than exerting a direct effect on a specific form of psychopathology.

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Section: Effects Of Prenatal Stress On Behavior Of Rodent Offspringmentioning

confidence: 94%

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Huizink¹,

Mulder²,

Buitelaar³

2004

Psychological Bulletin

426

294

View full text Add to dashboard Cite

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“…Increased catecholamine activity during development could inhibit the activity of aromatase in the medial amygdaloid nucleus [49] and the nuclear uptake of oestradiol after its conversion from testosterone [50]. Shorter periods of maternal restraint that allow movement, were shown to heighten sexual activity of the male offspring at maturity and did not affect behaviour in a novel environment [51]. Thus, the differential effect of various maternal stressors on male sexual behaviour may depend on the identity and relative amounts of hormones released in the mother in relation to foetal brain development [52].…”

Section: Sex Differences In Size Of Brain Structures and In Behaviourmentioning

confidence: 95%

Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour

2007

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An increased incidence of anxiety, depression and attention deficits in children has been linked to psychological stress during pregnancy. Subjection of a pregnant rat to stress at a time when the foetal limbic and hypothalamic pituitary adrenal (HPA) axes develop results in anxiogenic and depressive behaviour and learning and attention deficits in the offspring, which depend on its gender, intensity and timing of the maternal stress and behaviour being tested. Maternal stress increases corticosterone levels in the foetal brain, decreases foetal testosterone and brain aromatase activity in males, and alters brain catecholamine activity to that in females. Learning deficits, reductions in hippocampal neurogenesis, LTP and dendritic spine density in the prefrontal cortex are more readily seen in prenatally-stressed males, while anxiety, depression and increased response of the HPA axis to stress are more prevalent in females. Genders may differ in the sensitivity of developing brain areas to stress hormones.

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“…Other protocols used various stressors applied daily in repeated sequences (DeFries, Weir, & Hegmann, 1967;Pardon, Gerardin, Joubert, Perez-Diaz, & Cohen-Salmon, 2000). In each of these studies, the animals were subjected to stressors chronically, either during the entire pregnancy (Hockman, 1961;Fride & Weinstock, 1984;Rojo et al, 1985), the first (Suchecki & Palermo-Neto, 1991) or the second half of pregnancy (Herrenkohl & Whitney, 1976;Szuran, Zimmermann, & Welzl, 1994;Williams, Davis, McCrea, Long, & Hennessy, 1999), or at least during several consecutive days (Archer & Blackman, 1971;Fujioka et al, 1999;Sobrian, 1977).…”

Section: Effects Of Prenatal Stress: An Animal Modelmentioning

confidence: 99%

Effects of pre‐ and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: A review

Chapillon

Patin

Roy

et al. 2002

Developmental Psychobiology

183

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Interactions between the organism and its environment, during pregnancy as well as during the postnatal period, can lead to important neurobehavioral changes. We briefly review the literature, and successively present the main results from our laboratory concerning the behavioral effects of prenatal stress, differential rearing conditions, and postnatal handling. We show that submitting primiparous DA/HAN rats to an acute emotional stress (exposure to a cat) at gestational day10, 14, or 19 leads to greatly increased mortality of pups and to decreased body weight of surviving animals. The effects of such a stressor on emotional reactivity are less obvious. Cognitive processes are impaired depending on the learning task. Enriched environments restore abnormal behaviors (emotional reactivity, motor skills, motor and spatial learning) due to brain trauma or genetic deficiencies. In any case, environmental enrichment does prevent or slow down aging effects. The effects of postnatal handling noted when using classical tests of emotional reactivity also are clear when defensive reaction paradigms are used. Furthermore, pregnant females that are early handled are less anxious than nonhandled females. We hypothesize that, when subjected to a stressor, the offspring of early-handled females would be protected from the deleterious effects of this stress compared to pups of nonhandled females.

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Effects of low stress during pregnancy on certain parameters of the offspring

Cited by 32 publications

References 19 publications

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour

Effects of pre‐ and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: A review

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