Effects of Lowered Environmental Temperature on the Growth of Exoerythrocytic Stages of Plasmodium Berghei *

Yoeli, Meir; Young, Charles Y.F.; Jadin, J

doi:10.4269/ajtmh.1975.24.769

Cited by 6 publications

(8 citation statements)

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“…In addition, blood-stage parasite development may be affected by TT. Rats infected with two different strains of Plasmodium berghei had schizont-stage parasites of smaller sizes when exposed to colder temperatures (12°C) compared to TT, highlighting a potential protective effect of lower temperatures (68).This difference was not observed in rats housed at 20°C (68). Housing density also seems to be a factor in the outcome of Plasmodium infection.…”

Section: Parasite Infectionsmentioning

confidence: 92%

“…The effects of TN on the outcome of parasitic infections are still largely unraveled. However, a few studies investigating the role of temperature on parasitized murine hosts offer insights into potential consequences of TN housing on parasitic disease models (67)(68)(69)(70)(71)(72).…”

Section: Parasite Infectionsmentioning

confidence: 99%

“…For each of those diseases, a wide variety of models exist, constituted of various mouse strain and parasite species/strain combinations that can be investigated at TN. In addition, many of the studies described above did not acclimatize the animals to the temperature conditions, which could bias the results (68,69,72). Murine host sex and age differences, as well as difference in acclimatization time and caging system will also have to be taken into consideration when conducting future experiments.…”

Section: Parasite Infectionsmentioning

confidence: 99%

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Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?

Vialard

Olivier

2020

Front. Immunol.

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One of the major challenges the scientific community faces today is the lack of translational data generated from mouse trials for human health application. Housing temperature-dependent chronic cold stress in laboratory rodents is one of the key factors contributing to lack of translatability because it reveals major metabolic differences between humans and rodents. While humans tend to operate at temperatures within their thermoneutral zone, most laboratory rodents are housed at temperatures below this zone and have an increased energy demand to generate heat. This has an impact on the immune system of mice and thus affects results obtained using murine models of human diseases. A limited number of studies and reviews have shown that results obtained on mice housed at thermoneutrality were different from those obtained from mice housed in traditional housing conditions. Most of those studies, focused on obesity and cancer, found that housing mice at thermoneutrality changed the outcomes of the diseases negatively and positively, respectively. In this review, we describe how thermoneutrality impacts the immune system of rodents generally and in the context of different disease models. We show that thermoneutrality exacerbates cardiovascular and auto-immune diseases; alleviates asthma and Alzheimer’s disease; and, changes gut microbiome populations. We also show that thermoneutrality can have exacerbating or alleviating effects on the outcome of infectious diseases. Thus, we join the call of others in this field to urge researchers to refine murine models of disease and increase their translational capacity by considering housing at thermoneutrality for trials involving rodents.

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Section: Parasite Infectionsmentioning

confidence: 92%

Section: Parasite Infectionsmentioning

confidence: 99%

Section: Parasite Infectionsmentioning

confidence: 99%

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Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?

Vialard

Olivier

2020

Front. Immunol.

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“…He also observed an increase in cecal trichomonads when hosts were placed in heated cages (Noble, 1961). The most recent study in this area is con cerned with effects of lowered environmental temperature on the growth of the exoerythrocytic stages of Plasmodium berghei, a malarial parasite of rodents (Yoeli et al, 1975 On the basis of preliminary observations that environ-mental temperature appears to influence helminth infections in homeothermic animals, studies were initiated to determine the extent of such an influence on schistosome infections in mice. Schistosomes were chosen as the test species for several reasons: (1) observations of Cornford required confirmation by means of more extensive experimentation;…”

Section: Gongylonema Longispiculum In Citellus Citellusmentioning

confidence: 99%