2020
DOI: 10.1254/jpssuppl.93.0_2-yia-41
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Effects of <i>Goreisan</i> on LPS-induced diarrhea and decrease in aquaporin 3 expression in intestinal epithelial cells.

Abstract: Goreisan is often used for gastrointestinal symptoms associated with bacterial and viral infections, to care diarrhea and to prevent general dehydration. Although several clinical reports have shown the effectiveness of Goreisan, pharmacological properties and underlining mechanism of Goreisan has not been clear. In this study, therefore, we investigated the antidiarrheic effect of Goreisan using a mouse model of enterocolitis induced by Lipopolysaccharide (LPS). Goreisan did not affect TNF-α mRNA expression, … Show more

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“…LPS initially acts on the local immune system, leading to water influx (diarrhea) as a direct response of AQP1 to the antigen in the small and large intestines [12]. Moreover, AQP3 is diminished in the intestinal epithelium of LPStreated mice [13]. The liver is also a preferential target for sepsis-induced injury.…”
Section: Introductionmentioning
confidence: 99%
“…LPS initially acts on the local immune system, leading to water influx (diarrhea) as a direct response of AQP1 to the antigen in the small and large intestines [12]. Moreover, AQP3 is diminished in the intestinal epithelium of LPStreated mice [13]. The liver is also a preferential target for sepsis-induced injury.…”
Section: Introductionmentioning
confidence: 99%