Effects of &lt;i&gt;Vernonia cinerea&lt;/i&gt; on reproductive performance in streptozotocin-induced diabetic rats

Pomjunya, Atchariya; Ratthanophart, Jasada; Fungfuang, Wirasak

doi:10.1292/jvms.16-0466

Cited by 16 publications

(13 citation statements)

References 39 publications

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“…However, in the present study, adding 2 mM GA to semen extender resulted in frozen‐thawed spermatozoa with significantly highest total motility and also highest progressive motility (albeit not significantly different from controls). Similarly, various fruit (Nikseresht, Fallahzadeh, Toori, & Mahmoudi, ) and plant (Pomjunya, Ratthanophart, & Fungfuang, ) extracts that contained GA enhanced reproductive performance in rats. Furthermore, feeding diabetic rats 10 or 40 mg/kg of Vernonia cinerea L., plants, containing phytochemicals that include GA, improved number of spermatozoa, their motility and blood testosterone concentrations (Pomjunya et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, various fruit (Nikseresht, Fallahzadeh, Toori, & Mahmoudi, ) and plant (Pomjunya, Ratthanophart, & Fungfuang, ) extracts that contained GA enhanced reproductive performance in rats. Furthermore, feeding diabetic rats 10 or 40 mg/kg of Vernonia cinerea L., plants, containing phytochemicals that include GA, improved number of spermatozoa, their motility and blood testosterone concentrations (Pomjunya et al, ). In other studies, GA (60 or 120 mg/kg for 7 or 14 d respectively) decreased percentage abnormal spermatozoa and reproductive toxicity in rats given anti‐cancer and anti‐neoplastic drugs, with concurrent increases in motility and viability of epididymal spermatozoa (Olusoji et al, ; Oyagbemi et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

et al. 2019

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The objective was to determine effects of gallic acid (GA) and carnosic acid (CA), present in carob pods and rosemary extract respectively, on frozen-thawed ram spermatozoa. Thirty ejaculates were collected from five Merino rams, pooled, diluted in Tris-based extender and divided into five equal portions containing: 0.05 or 2 mM of GA; 0.05 or 0.2 mM of CA; or no additive (control). Extended semen was equilibrated at +4°C, loaded into straws, held 5 cm above liquid nitrogen for 12 min then plunged.Computer-aided sperm analysis was used to assess motility, whereas flow cytometry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

et al. 2019

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“…Further; highconcentration of V. cinerea showed an anti-diabetic activity and significantly increased the sperm count. Hence, it can be concluded that supplementation of V. cinerea remarkably restored the testicular property and testosterone amount in diabetic male mice (Pomjunya, Ratthanophart, & Fungfuang, 2017).…”

Section: Liver Glycogen Accumulation Inducing Effectsmentioning

confidence: 82%

“…Hence, it can be concluded that supplementation of V . cinerea remarkably restored the testicular property and testosterone amount in diabetic male mice (Pomjunya, Ratthanophart, & Fungfuang, 2017).…”

Section: Pharmacological Activities Of Plant‐based Extracts and Compomentioning

confidence: 99%

Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development

Jugran

Rawat

Devkota

et al. 2020

Phytotherapy Research

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Diabetes is a disease of serious concern faced by the health care industry today. Primary diabetes mellitus and its complications are still costly to manage with modern drugs. Extensive research on the screening of anti‐diabetic agents in past decades established natural products as one of the major potential sources of drug discovery. However, only a few drugs of plant origin have been scientifically validated. Therefore, the development of new anti‐diabetic drugs is of great demand. Hence, natural products could be explored as potential anti‐diabetic drugs. Natural plants derived extracts and molecules like berberine, ginsenosides, curcumin, stevioside, gingerols, capsaicin, catechins, simple phenolic compounds, anthocyanins, resveratrol, genistein and hesperidin obtained from different species are used for curing diabetes and found to possess different action mechanisms. In this review, the importance of medicinal plants and their active constituents for anti‐diabetic agents are described. The present study also emphasized the importance of diabetes control, reduction in its complications and use of the anti‐diabetic agents. The detailed action mechanism of these extracts/compounds for their activities are also described. However, the anti‐diabetic drugs from plant origin require scientific validation through animal and clinical studies to exploit in terms of modern commercial medicines.

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“…[34] Our data showed that STZinduced diabetic rats have severe loss in body weight which is consistent with the findings of other investigators. [35,36] This marked reduction in body weight may be breakdown of structural tissue protein in diabetic state. Diabetes causes remarkable increase in skeletal muscle catabolism along with reduction in protein biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Maiti¹

2017

IJGP

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Background: Tamarindus indica Linn. (Caesalpiniaceae) is a well-known traditional plant used by the tribes as well as rural sectors of tropical countries. Locally, it is named as Tantul and recognized as therapeutic uses of different diseases. Aim: The present study aimed to evaluate the efficacy of hydromethanolic extract of T. indica Linn. seed in streptozotocin (STZ)-induced diabetic testicular dysfunction correction. Materials and Methods: STZ-induced diabetic state has been established here by single intramuscular injection of STZ (6 mg/100 g body weight in citrate buffer, pH 4.5) resulted hyperglycemia. STZ-induced experimental diabetes resulted testicular dysfunctions evaluated by sperm count, sperm motility, viability, and seminal vesicle fructose content as well as by the level of serum testosterone. Testicular oxidative stress has been observed by the monitoring of catalase, peroxidase, superoxide dismutase, and glutathione-S-transferase activities. Quantification of thiobarbituric acid reactive substances and conjugated diene in testicular tissue was assessed. General and metabolic toxicity assessment parameters were studied. Results: Administration of hydromethanolic extract to STZ-induced diabetic rat at the dose of 80 mg/100 g body weight/day for 28 days resulted a significant protection in fasting blood glucose, serum insulin, and serum testosterone levels (P < 0.05) along with the correction of testicular above-mentioned parameters as well as semen analysis parameters toward the control level (P < 0.05). This extract has no general toxic effect on the body weight, along with no metabolic toxicity that was reflected here by the assessment of serum glutamate oxaloacetate transaminase and pyruvate transaminase activities. Conclusion: These data demonstrated that T. indica significantly improved STZ-induced diabetic complication in rat testis. This study suggested that hydromethanolic extract might have a protective role against oxidative stress-induced impairment in testicular functions in diabetic rats.

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Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Cited by 16 publications

References 39 publications

Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

Gallic and carnosic acids improve quality of frozen‐thawed ram spermatozoa

Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development

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