Effects of LTC4 and BW 755C, a blocker of its synthesis, on contraction in smooth muscle and operation of voltage-dependent calcium channels in nerve cells

Voltage-dependent Ca" channels were identified in CHO-KI cells, currently used in molecular biology studies. Experimental data obtained at both macroscopic and single-channel levels using the patch-clamp technique show that the Cal' current in CHO cells is similar to the high-threshold L-type of Ca'+ current previously observed in excitable cells. It can be carried by Ca" or Ba" ions, blocked by both inorganic (Co") and organic (nifedipine, isradipine) Ca*' channel blockers. The unitary Ca'+ channel activity was characterized by a conductance of 19 pS in 60 mM Ca2+, by single exponential distribution of open times (t = 0.84 ms) and biexponential distribution of closed times (tr = 1.67 ms, t, = 7.9 ms ). However, the functional role of these Ca" channels in CHO cells remains unclear.

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Voltage‐dependent Ca²⁺ channels in Chinese hamster ovary (CHO) cells

Skryma

Prevarskaya

Vacher

et al. 1994

FEBS Letters

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Effects of LTC4 and BW 755C, a blocker of its synthesis, on contraction in smooth muscle and operation of voltage-dependent calcium channels in nerve cells

Cited by 1 publication

References 16 publications

Voltage‐dependent Ca²⁺ channels in Chinese hamster ovary (CHO) cells

Voltage‐dependent Ca²⁺ channels in Chinese hamster ovary (CHO) cells

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Effects of LTC4 and BW 755C, a blocker of its synthesis, on contraction in smooth muscle and operation of voltage-dependent calcium channels in nerve cells

Cited by 1 publication

References 16 publications

Voltage‐dependent Ca2+ channels in Chinese hamster ovary (CHO) cells

Voltage‐dependent Ca2+ channels in Chinese hamster ovary (CHO) cells

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Voltage‐dependent Ca²⁺ channels in Chinese hamster ovary (CHO) cells

Voltage‐dependent Ca²⁺ channels in Chinese hamster ovary (CHO) cells