Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat

Yang, Min; Ding, Juan; Zhou, Xu; Zhang, Xuehong; Hong, Tao; Wang, Yin; Li, Guanghua

doi:10.3892/br.2014.291

Cited by 12 publications

(6 citation statements)

References 46 publications

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“…Polysaccharide has many biological activities, such as antioxidant, antibacterial, antitumor, neuroprotection, immunomodulation, anti-inflammation, anticoagulant, improvement of hepatic function, and promotion of burn wound healing (Khoo, Abas, Abdullah, Mohd Tohit, & Hamid, 2014;Li & Shah, 2014;Pang et al, 2013;Pi, Wang, Lu, Lu, & Chen, 2014;Wang et al, 2014aWang et al, , 2014bXiao et al, 2014;Yang, Lu, Hsieh, & Lin, 2014a;Yang et al, 2014b). Jia, Yang, Wang, Liu, and Xie (2014) reported that polysaccharide from Laminaria japonica exhibited hypoglycemic and hypolipidemic activities in mice with experimentally induced diabetes.…”

Section: Discussionmentioning

confidence: 97%

Red bayberry extract prevents high-fat diet-induced metabolic disorders in C57BL/6 mice

Cai

Zhang

et al. 2015

Journal of Functional Foods

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Section: Discussionmentioning

confidence: 97%

Red bayberry extract prevents high-fat diet-induced metabolic disorders in C57BL/6 mice

Cai

Zhang

et al. 2015

Journal of Functional Foods

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“…Furthermore, Guo et al demonstrated that L. barbarum polysaccharides could increase the level of cortisol and epinephrine [62]. In the ophthalmic field, wolfberries are known to be beneficial for presbyopia-induced dry eye, blurred vision, ocular fatigue, age-related macular degeneration, diabetic retinopathy, UV light-induced retinal degeneration, retinitis pigmentosa, and even glaucoma [63].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense

Horng

Ma²,

Shieh

2021

Evidence-Based Complementary and Alternative Medicine

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Background. Presbyopia is a primary cause of a decline in near vision. In this study, we developed a new mixed herbal medicine to retard presbyopic progression and increase the amplitude of accommodation (AA), which is beneficial for near vision. Methods. A total of 400 participants between the ages of 45 and 70 years were recruited. We designed the mixed herbal drug to include Cassiae Semen (200 mg), wolfberry (200 mg), and Dendrobium huoshanense (DD) (40 mg) in one capsule. In experiment 1, the recruited subjects were directed to perform a push-up test to measure their AA; this was then converted to the additional diopters of reading glasses. In experiment 2, 240 subjects took three capsules daily for six months and then stopped medical therapy for a six-month follow-up. In experiment 3, 160 subjects were randomly categorized into four groups: a placebo group, low-dose group (LDG) (1 capsule daily), middle-dose group (MDG) (two capsules daily), and high-dose group (HDG) (three capsules daily). The 160 volunteers took different doses for six months and then stopped treatment, accompanied by another six-month follow-up. In experiments 2 and 3, the change in AA, uncorrected far visual acuity (UFVA), and uncorrected near visual acuity (UNVA) were recorded each month for one year. Results. In experiment 1, AA was found to decrease with age and a great deal of additional power was needed in older individuals. In experiment 2, the mean AA reached a maximum value of 2.1D ( P < 0.05) after six months, while the UNVA improved by about two to three lines of a Jaeger chart in most of the subjects. At nine months, all the means decreased slightly to 2.0 D ( P < 0.05). This meant that the mixed herbal medicine could still maintain AA for another three months because the herbal therapy was stopped at the seventh month. In experiment 3, the maximal AA was 2.8D, 2.9D, and 3.2D ( P < 0.05) in the LDG, MDG, and HDG after six-month treatments, respectively. Experiment 3 showed that AA gain occurred in a dose-dependent manner; the higher the dose, the greater the AA value. Conclusion. Only two studies on the use of herbal drugs for presbyopia have been reported in PubMed. In our study, we found that taking a mixed herbal drug caused an excellent gain in AA. This is the first study to report that the characteristics of the new herbal regimen could retard and even ameliorate presbyopia.

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“…The main functional components of L. bararum include zeaxanthin and carotene, polysaccharides and small molecules such as betaine, cerebroside, beta-sitosterol, p-coumaric, and various vitamins. Previous in vivo and in vitro experiments have suggested that LBPs may have multiple targets and pharmacological effects, including neurological protection ( 41 ), antioxidation and anti-aging ( 42 , 43 ), increasing immunity ( 44 ), protecting liver cells ( 45 ) and the protection of reproductive system functions ( 28 ). Currently, increasing numbers of international studies have demonstrated the ability of LBPs to repair damaged neurons ( 25 – 27 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells

Tian

Chen

Cui

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to observe the effects of a general extract of Lycium bararum polysaccharides (LBPs) on methylmercury (MeHg)-induced damage in hippocampus neural stem cells (hNSCs). The hippocampal tissues of embryonic day 16 Sprague-Dawley rats were extracted for the isolation, purification and cloning of hNSCs. Following passage and proliferation for 10 days, the cells were allocated at random into the following groups: Control, LBPs, MeHg and MeHg + LBPs. MTT and microtubule-associated protein 2 (MAP-2)/glial fibrillary acidic protein/Hoechst immunofluorescence tests were performed to detect the differentiation and growth of hNSCs in the various groups. The differentiation rate of MeHg-treated hNSCs and the perimeter of MAP-2-positive neurons were 3.632±0.63% and 62.36±5.58 µm, respectively, significantly lower compared with the control group values of 6.500±0.81% and 166±8.16 µm (P<0.05). Furthermore, the differentiation rate and the perimeter of MAP-2-positive neurons in LBPs groups cells was 7.75±0.59% and 253.3±11.21 µm, respectively, significantly higher compared with the control group (P<0.05). The same parameters in the MeHg + LBPs group were 5.92±0.98% and 111.9±6.07 µm, respectively, significantly higher than the MeHg group (P<0.05). The astrocyte differentiation rates in the MeHg and MeHg + LBPs group were 41.19±2.14 and 34.58±1.70, respectively (P<0.05). These results suggest that LBPs may promote the generation and development of new neurons and inhibit the MeHg-induced abnormal differentiation of astrocytes. Thus, LBPs may be considered to be a potential new treatment for MeHg-induced neurotoxicity in hNSCs.

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Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat

Cited by 12 publications

References 46 publications

Red bayberry extract prevents high-fat diet-induced metabolic disorders in C57BL/6 mice

Red bayberry extract prevents high-fat diet-induced metabolic disorders in C57BL/6 mice

Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense

Effect of Lycium bararum polysaccharides on methylmercury-induced abnormal differentiation of hippocampal stem cells

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