Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

Kim, Ji Young; Paik, Jean Kyung; Kim, Oh Yoen; Park, Hae Won; Lee, Jin Hee; Jang, Yangsoo; Lee, Jong Ho

doi:10.1016/j.atherosclerosis.2010.11.036

Cited by 172 publications

(149 citation statements)

References 18 publications

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“…In a randomized double-bind placebo-controlled study undertaken in over 100 habitual cigarette smokers and alcohol consumers, men 22-57-aged, the possible protective effect of lycopene (134) against heart disease was evaluated in these oxidative stress conditions (smoke and alcohol). The endothelial function improved due to the reduction of oxidative stress (increased SOD activity and decreased oxidative DNA damage) in the lycopenesupplemented group, suggesting a beneficial role of this carotene via antioxidant mechanisms in the prevention of atherosclerosis [83]. Furthermore, in vivo studies demonstrated that chronic ethanol administration increased lipid peroxidation and decreased total antioxidant capacity in the heart of rats.…”

Section: Cardioprotectionmentioning

confidence: 95%

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Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

297

157

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Reactive Oxygen Species are involved in the pathological development of many important human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes and many others. The most promising strategy to prevent from the oxidative damage caused by these reactive species is the use of antioxidant molecules. These compounds can act as direct antioxidants through free radical scavenging mechanisms and/or as indirect antioxidants by enhancing the antioxidant status (enzymatic and non-enzymatic). Terpenes, one of the most extensive and varied structural compounds occurring in nature, display a wide range of biological and pharmacological activities. Here we highlight their antioxidant properties. Due to their antioxidant behaviour terpenes have been shown to provide relevant protection under oxidative stress conditions in different diseases including liver, renal, neurodegenerative and cardiovascular diseases, cancer, diabetes as well as in ageing processes. Evidence for this comes from the increasing number of publications on this issue in recent years. This review provides a complete overview of the natural terpenes with potential antioxidant properties, focusing on their source, structures, antioxidant mechanisms through which they exert their pharmacological and possible therapeutic activities.

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Section: Cardioprotectionmentioning

confidence: 95%

“…A study from the year 2011 on 26 healthy men showed that eight weeks of lycopene (134) supplementation lead to an increment of plasma SOD activity and a decrease in comet tail length migration of lymphocyte DNA, suggesting that this compound could exert a protective effect against oxidative stress-induced endothelial dysfunction [94].…”

Section: Cardioprotectionmentioning

confidence: 99%

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

297

157

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“…The authors concluded that increased serum lycopene after supplementation can reduce oxidative stress. 52 Lycopene taken in doses equal to or greater than 25 mg daily can reduce LDL-C by about 10% (comparable to the effect of low doses of statins) in patients with slightly elevated cholesterol levels: A review published in Maturitas summarizes current evidence on the effect of lycopene on serum lipid concentrations and blood pressure. The authors conducted metaanalyses on studies in the PubMed and Cochrane databases for intervention studies investigating the effect of lycopene on blood lipids or blood pressure for a minimum duration of 2 weeks.…”

Section: Supplementing Lycopene Can Reduce Oxidative Stressmentioning

confidence: 98%

The Polyphenolic Antioxidant Resveratrol, the Carotinoid Lycopene, and the Proanthocyanidin Pycnogenol

Fried

2014

Erectile Dysfunction as a Cardiovascular Impairment

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“…As shown in Table 4, carotenoids have a beneficial effect on endothelial cell function. In a study of healthy men, lycopene supplementation was suggested to inhibit oxidative stressmediated decreases in endothelium function [48]. For example, lycopene prevents LPSinduced MCP-1, IL-6, and VCAM-1 expression in human endothelial cells [14].…”

Section: Preventive Effects Of Carotenoids On Cardiovascular Disease mentioning

confidence: 99%

Carotenoids Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease

Yamagata¹

2017

Carotenoids

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Regular consumption of fruits and vegetables can help reduce the risk for cardiovascular disease (CVD) and its associated mortality. A diet rich in fruits and vegetables is thought to have cardioprotective effects, but the specific components of these foods that provide this protection are unclear. Antioxidants such as vitamin C, carotenoids, and polyphenols in fruits and vegetables likely contribute to the reduction in risk of CVD by minimizing cholesterol oxidation in blood vessel walls. Meanwhile, cardioprotective effects afforded by the carotenoids lycopene, α-carotene, β-carotene, β-cryptoxanthin, lutein, and zeaxanthin have been reported in many studies. Carotenoids are naturally occurring fat-soluble pigments that are present at high levels in tomatoes and carrots. Carotenoids play an important role in staving off atherosclerosis via antioxidant activities that reduce lipid peroxidation in low-density lipoproteins. Lycopene reduces endothelin-1 gene expression by suppressing generation of reactive oxygen species and inducing heme oxygenase-1 expression in human endothelial cells. Thus, carotenoids may mitigate endothelial dysfunction by promoting direct antioxidative effects and inducing expression of several genes. Structural and functional differences among carotenoids may explain their unique biologic activities. In this review, the roles of carotenoids in relation to their influence on vascular endothelial functions and cardioprotective effects are discussed.

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Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

Cited by 172 publications

References 18 publications

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

The Polyphenolic Antioxidant Resveratrol, the Carotinoid Lycopene, and the Proanthocyanidin Pycnogenol

Carotenoids Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease

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