Effects of lymphocyte, C-reactive protein and prealbumin levels on clinical typing and course of disease in children infected with novel coronavirus

Abstract

Objectives: To investigate the effects of lymphocyte (LY), C-reactive protein (CRP) and prealbumin (PA) levels on the clinical typing and course of disease in children infected with novel coronavirus (2019-nCoV) at the early stage.
 Methods: A total of 140 children with 2019-nCoV infection diagnosed in Shijiazhuang People’s Hospital and Hebei Provincial Chest Hospital from January 2021 to February 2021 were selected for this study. According to the clinical symptoms, laboratory results and imaging examination, the children were divided into asymptomatic infection group, mild infection group and common infection group. The levels of white blood cell (WBC), LY, CRP, PA, albumin (ALB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK) and creatine kinase MB isoenzyme (CKMB) in the children were recorded on the 2nd d after the positive detection of 2019-nCoV nucleic acid.
 Results: There were 73(52.1%) children in the asymptomatic infection group, 35(25.0%) children in the mild infection group and 32(22.9%) children in the common infection group. LY level in the common infection group was lower than that in the asymptomatic infection group and the mild infection group (F= 3.152, both p< 0.05). CRP level in the common infection group was higher than that in the asymptomatic infection group and the mild infection group (F= 6.343, both p< 0.05). CRP level in the mild infection group was higher than that in the asymptomatic infection group (t= 2.052, p< 0.05). PA level in the common infection group and the mild infection group was lower compared with the asymptomatic infection group (F= 5.229, both p< 0.05). WBC, ALB, AST, ALT, CK and CKMB levels in the three groups showed no statistical significance (F= 1.803, F= 1.208, F= 2.391, F= 1.973, F= 0.401, F= 1.332, respectively, all p> 0.05). Correlation analysis demonstrated that LY and PA levels were negatively correlated with hospital stay (r= -0.265, r= -0.325, both p< 0.050), but CRP level was not correlated with hospital stay (r= -0.039, p> 0.05).
 Conclusion: CRP is correlated with the clinical typing of children with 2019-nCoV infection, while LY and PA levels may be closely correlated with the clinical typing and course of treatment of children with 2019-nCoV infection.
 doi: https://doi.org/10.12669/pjms.38.5.5286
 How to cite this:Bi J, Zhang Y, Zhang J, Han Q, Ji C, Zhen W. Effects of lymphocyte, C-reactive protein and prealbumin levels on clinical typing and course of disease in children infected with novel coronavirus. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5286
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fibrinogen-to-prealbumin and C-reactive protein-to-prealbumin ratios as prognostic indicators in severe fever with thrombocytopenia syndrome

“…In recent years, FPR and CPR have emerged as promising indicators capable of capturing both systemic inflammation and nutritional status in various diseases. This combined index of the FPR and CPR holds potential as a prognostic biomarker in patients with conditions such as tumors ( Matsunaga et al., 2020 ; Sun et al., 2020 ; Maruyama et al., 2022 ; Kwon et al., 2023 ), infectious diseases ( Yue et al., 2015 ; Bi et al., 2022 ), autoimmune diseases ( Cheng et al., 2021 ), and other ailments ( Zang et al., 2020 ; Yamada et al., 2021 ; Huang et al., 2022 ). To date, no studies have examined whether FPR and CPR can assess the prognosis of patients with SFTS.…”

“…Additionally, during inflammatory processes, cytokines such as IL-6, IL-1, and TNF-α also contribute to the decrease of PA levels ( Yue et al., 2015 ). The prognostic potential of PA has been demonstrated in various conditions including acute kidney injury ( Xie et al., 2011 ), tumors ( Kwon et al., 2023 ), infectious diseases ( Bi et al., 2022 ), and heart failure ( Lourenço et al., 2014 ). Although PA demonstrated a good predictive ability for mortality among patients with SFTS (AUC = 0.791), statistical significance was not achieved in the univariate analysis ( P = 0.098), likely due to the limited sample size.…”