Effects of lysine-vasopressin and 1-deamino-8-d-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients

Laczi, F.; Valkusz, Z.; László, Ferenc; Wagner, Andreas; Járdánházy, T.; Szász, Anna; Szilárd, J.; Telegdy, Gyula

doi:10.1016/0306-4530(82)90011-7

Cited by 56 publications

(16 citation statements)

References 14 publications

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“…Thus in a study by Gilot et al (1980) amnesic performances of patients suffering from diabetes insipidus were reported to improve after treatment with a synthetic vasopressin (DDAVP), but since this drug also eliminates the need to wake up at night to urinate an alternative interpretation of the improved memory performance in terms of better sleep cannot be ruled out. Another study conducted by Laczi et al (1982) failed to provide a proper control group against which to compare the performance of the treatment group. In other studies it is questionable whether the treatment group was homogenous enough to allow a fair evaluation of a drug which might not be equally effective in dealing with all forms of amnesia.…”

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confidence: 99%

Does DGAVP influence memory, attention and mood in young healthy men?

1987

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The influence of an increasing dose of the vasopressin-like peptide DGAVP (desglycinamide-arginine-vasopressin) on memory was investigated in two groups of ten healthy male volunteers to provide information about the hypothesis of improvement of memory by vasopressin. At the same time we evaluated the effect of DGAVP on mood, alertness or sleepiness in a double-blind placebo-control design. The treatment group received at 9.15 a.m. intranasally a daily increasing dose from 0.1 mg at day 1 to 10.0 mg at day 5. DGAVP did not significantly affect any measure of memory or alertness. DGAVP did, however, produce a significant increase in concentration level and mood. The results of the present study provide no support for the vasopressin theory of memory improvement; rather, the results direct the attention to attention modulating effects.

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confidence: 99%

Does DGAVP influence memory, attention and mood in young healthy men?

1987

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“…ANP is known to have strong anxiolytic effects and specific actions on different levels of the hypothalamus-pituitary-adrenocortical (HPA) axis [6,7], such as inhibition of corticotropin-releasing hormone (CRH), adrenocorticotropin (ACTH) and cortisol secretion [8]. Contrary to that, AVP is known to enhance memory function and has been proposed to exert anxiogenic effects [9,10] as well as stimulate CRH and ACTH expression at both the hypothalamic and pituitary levels [11]. Furthermore, studies have demonstrated that AVP is implicated in appetite regulation [12] as well as depression and obsessive behavior [13,14].…”

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confidence: 99%

Alcohol-Induced Changes in Methylation Status of Individual CpG Sites, and Serum Levels of Vasopressin and Atrial Natriuretic Peptide in Alcohol-Dependent Patients during Detoxification Treatment

Glahn

Knorrenschild²,

Rhein

et al. 2013

Eur Addict Res

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Disturbances of volume-regulating peptides like vasopressin (AVP) and atrial natriuretic peptide (ANP) have been described in early abstinent alcohol-dependent patients. In a longitudinal approach, we investigated whether changes in AVP and ANP serum levels correlated to cytosine-phosphatidyl-guanine (CpG) methylation of the respective gene promoters on days 1, 7 and 14 of alcohol withdrawal. We analyzed the blood samples of 99 patients suffering from alcohol dependence alongside age- and BMI-matched controls. Concerning AVP promoter methylation, we observed an interaction between time of measurement and CpG loci with CpG 2 showing a significant increase in methylation from day 1 to 14. Serum levels of AVP were significantly decreased in the patient group. Compared to healthy controls, promoter-related DNA methylation of the ANP promoter was significantly reduced on days 7 and 14. Moreover, we detected a significant interaction between CpG position and group. In both cases the difference was mainly observed at CpG 1. The present study shows significant changes in the methylation status of individual CpG sites of AVP and ANP. Observing respective alterations of AVP serum protein levels in alcohol-dependent patients during detoxification treatment, we consider methylation as a possible mode of regulation for these proteins during alcohol detoxification.

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“…AVP and related peptides improve memory functions in healthy subjects (Laczi et al 1982a;Legros et al 1978; Legros & Gilot 1979), in diabetes insipidus (DI) patients (Laczi et al 1982a;Gilot et al 1980), in depressed patients (Weingartner et al 1981) and in patients suffering from some but not all amne¬ stic syndromes (Drago et al 1981; Le Boeuf et al 1978;Oliveros et al 1978;Timsit-Berthier et al 1979; Koch-Henriksen & Nielsen 1981;Jenkins et al 1979). [Lys8]-vasopressin (LVP) or 1-desamino-[D-Arg8]-vasopressin (DDAVP) were used in near¬ ly all these studies. We observed however that DGAVP improved memory processes in healthy subjects and in DI patients (Laczi et al 1982b al.…”

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confidence: 99%

Lack of effect of desglycinamide-arginine-vasopressin (DGAVP) on memory in patients with Korsakoff's syndrome

Laczi

Ree

Balogh

et al. 1983

Acta Endocrinologica

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The effect of desglycinamide9-[Arg8]-vasopressin (DGAVP) on memory processes was studied in patients with Korsakoff's syndrome. Intranasal treatment with DGAVP for 7 days affected neither attention nor short-and long-term memories. It is suggested that treatment with DGAVP is not indicated for all types of memory disorders, and that the beneficial effect of this treatment may depend on the integrity of certain brain structures.

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Effects of lysine-vasopressin and 1-deamino-8-d-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients

Cited by 56 publications

References 14 publications

Does DGAVP influence memory, attention and mood in young healthy men?

Does DGAVP influence memory, attention and mood in young healthy men?

Alcohol-Induced Changes in Methylation Status of Individual CpG Sites, and Serum Levels of Vasopressin and Atrial Natriuretic Peptide in Alcohol-Dependent Patients during Detoxification Treatment

Lack of effect of desglycinamide-arginine-vasopressin (DGAVP) on memory in patients with Korsakoff's syndrome

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