Effects of Ma-Xing-Shi-Gan-Tang on bleomycin- induced lung fibrosis in rats

Chang, Chienliu; Lin, Chih‐Chan; Lien, Hsiao-Yin; Lin, Yung‐Chang; Chen, Yung-Husan; Chang, Fang‐Rong; Li, Zhenhua

doi:10.38212/2224-6614.2259

Cited by 1 publication

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“…Several lines of evidence indicate that NO has been involved in the pathogenesis of various chronic inflammatory diseases, such as rheumatoid arthritis [ 23 ], inflammatory bowel disease [ 24 ], diabetic retinopathy [ 25 ], cancer metastasis [ 26 ], and lung fibrosis [ 27 ]. In the present study, we set out to elucidate the anti-inflammatory activity of compounds 1 – 7 by assessment of their inhibition on NO production in LPS-activated murine macrophage RAW264.7 cells.…”

Section: Resultsmentioning

confidence: 99%

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen

Wang²,

Kuo

et al. 2019

Journal of Food and Drug Analysis

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Seven new isoprenyl phenolic ethers, namely fimbriethers A–G ( 1 – 7 ), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1 – 7 were not involved in the regulation of endothelial NOS-mediated NO production.

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