Effects of maduramicin on adult zebrafish (Danio rerio): Acute toxicity, tissue damage and oxidative stress

Ni, Han; Lin, Peng; Gao, Xiaona; Jiang, Hui; Ma, Junxiao; Li, Yanping; Jiang, Shanxiang

doi:10.1016/j.ecoenv.2018.10.040

Cited by 93 publications

(34 citation statements)

References 48 publications

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“…Previous studies have shown that SOD is the first enzyme to fight O 2 radicals and important endogenous antioxidants against oxidative stress, and GSH-dependent enzymes (GST, GPx and GR) are resistant to peroxidative damage [51]. Increased expression of antioxidant-related genes, the liver's antioxidant defense system is greatly activated to resist oxidative damage caused by heat stress and balance the body's oxidation and antioxidant levels [52]. The enhanced motor activity (SOD) of antioxidants, CAT and GPX1) leads to increased defense against oxygen and free radicals in laying hens.…”

Section: Effects Of Tp On Genes Expression Of Antioxidant Enzymes In mentioning

confidence: 99%

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Yang¹,

Lu²,

Zhu³

et al. 2019

Preprint

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The present study was conducted to evaluate the effects of dietary supplementation of tea polyphenol （TP） on serum hormone, serum enzyme activity, antioxidant-related and immune-related gene expression of laying hens under heat stress. A total of 288 Chinese yellow chicken (186 days old) were randomly distributed among two treatments, each of which included 6 replicates of 24 hens. Dietary treatments were that the basal diet was supplemented with 200 mg / kg tea polyphenol. The study lasted for 7 weeks, including 1 week of adaptation and 6 weeks of the formal test. The content of high-density lipoprotein cholesterol (HDL-C) and total protein (TP) in serum significantly decreased by dietary supplementation with tea polyphenol. Dietary tea polyphenol supplementation improved serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activity and decreased serum malondialdehyde (MDA) content in treatments compared to the control. However, supplementation of tea polyphenol did not affect the activity of serum catalase (CAT). The results indicated that long-term feeding of tea polyphenols help to increase the amount of hormones (FSH, E2) associated with reproduction in laying hens and thus improve egg production. It also improved the immune function of laying hens in high temperature environments. Adding tea polyphenols to the diet can significantly increase the serum IgG, IgM content of the laying hens and can upregulate the IgA content. Dietary supplementation of tea polyphenols in the laying hens significantly increased the expression of antioxidant enzyme-related genes (SOD, CAT and GPX1) in the liver. Moreover, the addition of tea polyphenols significantly increased the expression of immune-related genes (Interferon-γ (INF-γ), Interleukin 2 (IL-2) and Interleukin 4 (IL-4)) in the spleen. It is concluded that addition of tea polyphenols has a positive effect on antioxidant activity and immune function of laying hens.

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Section: Effects Of Tp On Genes Expression Of Antioxidant Enzymes In mentioning

confidence: 99%

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Yang¹,

Lu²,

Zhu³

et al. 2019

Preprint

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“…46,47 For instance, the activities of SOD in adult zebrafish were promoted significantly in 0.1 and 0.5 mg/L maduramicin exposure group, while it was inhibited at 2.5 mg/L group. 48 The increase of SOD activity might be due to the protection mechanism that eliminates excess ROS to offset oxidative stress. 32 When ROS content is so excessive that antioxidant defense system cannot eliminate, the antioxidant enzymes will be oxidatively modified, leading to decreased enzyme activity and function.…”

Section: Discussionmentioning

confidence: 99%

Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)

Jia

et al. 2020

Environmental Toxicology

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Various pollutants co‐exist in the aquatic environment such as carbamazepine (CBZ) and copper (Cu), which can cause complex effects on inhabiting organisms. The toxic impacts of the single substance have been studied extensively. However, the studies about their combined adverse impacts are not enough. In the present study, zebrafish were exposed to environmental relevant concentrations of CBZ (1, 10, and 100 μg/L), Cu (0.5, 5, and 10 μg/L) and the mixtures (1 μg/L CBZ + 0.5 μg/L Cu, 10 μg/L CBZ + 5 μg/L Cu, 100 μg/L CBZ + 10 μg/L Cu) for 45 days, the effects on nervous and antioxidant systems of zebrafish were investigated. The results demonstrated that, in comparison with single exposure group, the combined presence of CBZ and Cu exacerbated the effect of antioxidant system (the ability of inhibition of hydroxyl radicals (IHR), superoxide dismutase (SOD), catalase (CAT) and glutathione S‐transferase (GST)) but not nervous system (Acetylcholinesterase [AChE]). The qPCR results supported the changes of corresponding enzymes activities. Hepatic histopathological analysis verified the results of biomarkers. Our work illustrated that the toxicity of mixed pollutants is very complicated, which cannot simply be inferred from the toxicity of single pollutant, and calls for more co‐exposure experiments to better understanding of the co‐effects of pollutants on aquatic organisms.

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“…After the chronic exposure, each fish (15 specimens per experimental group) was well homogenized in 10 volumes of ice-cold saline (0.90% NaCl) and centrifuged at 5500 rpm for 10 min at 4 °C according to the previously reported protocol [ 58 , 59 ]. The supernatant of each sample was transferred to a clean PE tube and was divided into aliquots for total protein analysis, SOD, GPx, and MDA measurement.…”

Section: Methodsmentioning

confidence: 99%

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

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Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

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Effects of maduramicin on adult zebrafish (Danio rerio): Acute toxicity, tissue damage and oxidative stress

Cited by 93 publications

References 48 publications

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

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