Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms

Ebrahimi, Elham; Motlagh, Shiva Khayati; Nemati, Sima; Tavakoli, Zohreh

doi:10.5681/jcs.2012.026

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…To compare the effect of magnesium with vitamin B6, Ebrahimi et al enrolled 126 young girls and divided them into three groups of magnesium, vitamin B6, and placebo. Their results showed that although magnesium could significantly reduce some symptoms of dysmenorrhea such as craving, water retention, and anxiety, the effect of magnesium in terms of somatic changes and depression was equal to or less than that of vitamin B6 (28). This discrepancy between our results and those of Ebrahimi et al may be because they used magnesium 250 mg and different scales for assessing dysmenorrhea symptoms.…”

Section: Discussioncontrasting

confidence: 95%

Effectiveness of Magnesium on Menstrual Symptoms Among Dysmenorrheal College Students: A Randomized Controlled Trial

Yaralizadeh,

Nezamivand-Chegini,

Najar

et al. 2020

International Journal of Women’s Health and Reproduction Scienc

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Objectives: The aim of this study was to compare the impact of two different doses of magnesium on severity of menstrual symptoms. Materials and Methods: In this double-blind placebo-controlled trial, 60 students with moderate or severe dysmenorrhea were randomly allocated to two intervention groups and one control group (receiving 150 mg and 300 mg magnesium stearate, or placebo from the 15th day of menstruation until the following cycle, respectively). All participants reported their menstrual symptoms according to the Symptom Severity Scale 2 cycles before and 2 cycles after the intervention. The main outcomes included menstrual symptoms such as cramps, headache, foot pain, depression, irritability, general pain, and abdominal pain. Results: According to the results, although both doses of magnesium could significantly reduce all symptoms of dysmenorrhea compared to the placebo (P<0.001), magnesium 300 mg was more effective in decreasing symptoms such as cramps, headache, back pain, foot pain, depression, irritability, and abdominal pain. Conclusions: The results showed that both doses of magnesium stearate (150 and 300 mg) can reduce severity of menstrual symptoms although the effect was greater with magnesium stearate 300 mg.

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Section: Discussioncontrasting

confidence: 95%

Effectiveness of Magnesium on Menstrual Symptoms Among Dysmenorrheal College Students: A Randomized Controlled Trial

Yaralizadeh,

Nezamivand-Chegini,

Najar

et al. 2020

International Journal of Women’s Health and Reproduction Scienc

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“…Such as swelling of the extremities and abdominal and chest discomfort. 23 This study's results align with the research conducted by Anggraeni et al, which stated that there was no relationship between vitamin B6 intake and premenstrual syndrome (p>0.05). The results showed an improvement in PMS complaints after taking vitamin B6 supplements (p< 0.05).…”

Section: Relationship Of Vitamin B6 Intake With Premenstrual Syndromesupporting

confidence: 89%

Hubungan Asupan Vitamin B6 dengan Sindrom Pramenstruasi pada Siswi SMP

Amry

Tjhin

2022

J Biomedika dan Kesehat

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Latar BelakangBanyak wanita mengeluhkan gejala tidak nyaman beberapa hari sebelum menstruasi berupa masalah emosi sampai rasa tidak nyaman pada daerah perut, kondisi ini disebut sindrom pramenstruasi.Kurangnya zat gizi salah satunya vitamin B6 merupakan faktor risiko terjadinya sindrom pramenstruasi. Penelitian ini dilakukan untuk menilai hubungan asupan vitamin B6 dengan sindrom pramenstruasi pada siswi SMP. Metode Penelitian menggunakan metode observasional analitik dengan desain cross-sectional, pada 162 siswi SMPN 75 Jakarta, yang diambil dengan teknik cluster random sampling dan simple random sampling. Pengukuran kejadian sindrom pramenstruasi dilakukan dengan menggunakan kuesioner sPAF dan asupan vitamin B6 menggunakan kuesioner SQ-FFQ. Data hasil penelitian dianalisis menggunakan uji chi-square. Penelitian dilakukan setelah mendapat persetujuan etik nomor 7/KER-FK/II/2022. HasilHasil penelitian menunjukkan bahwa siswi yang mengalami sindrom pramenstruasi sebagian besar berusia 15-16 tahun (20.8%), mengalami menarche pada usia di bawah 12 tahun (16.4%), kurang melakukan olahraga (15.6%), memiliki indeks massa tubuh (IMT) pada kategori gizi berlebih (25.0%), dan mengonsumsi makanan yang mengandung cukup vitamin B6 (15.0%). Hasil analisis bivariat antara variabel bebas dan tergantung didapatkan tidak ada hubungan bermakna antara sindrom pramenstruasi dengan usia (p = 0.054), usia menarche (p = 0.630), olahraga (p = 0.726), IMT (p = 0.131), dan asupan vitamin B6 (p=1.000). KesimpulanTidak terdapat hubungan yang bermakna antara asupan vitamin B6, karakteristik sosiodemografi (usia, usia menarche), olahraga, dan indeks massa tubuh (IMT) dengan sindrom pramenstruasi.

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“…Some observation of low magnesium levels in women with PMS compared to controls has led to the theory that magnesium supplementation may alleviate symptoms. 157 Limited evidence additionally supports use of magnesium supplementation at 250 mg daily, 158,159 particularly in combination with pyridoxine, 160 for PMS, although to date superiority over placebo has not been demonstrated; overall, improved quality of data is necessary to guide recommendations. 161 Other Dietary Supplements Omega-3 polyunsaturated fatty acids (PUFAs), believed to exert various biological functions including monoaminergic pathway enhancement, and control of pain pathways and inflammation, have been the focus of study for use in PMS.…”

Section: Mineralsmentioning

confidence: 99%

Management of Premenstrual Dysphoric Disorder: A Scoping Review

Carlini,

Lanza di Scalea,

McNally

et al. 2024

FOC

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Premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS) refer to physical, cognitive, or affective symptoms that arise in the late luteal phase and remit with menses. The present work is a clinically focused scoping review of the last twenty years of research on treatment for these disorders. A search of key terms using the PubMed/Medline, the Cochrane Library, Embase, and Web of Science databases was performed, and 194 studies of adult women met initial inclusion criteria for review. Research studies concerning medications, pharmacological and non-pharmacological complementary and alternative medicine treatments, and surgical interventions with the most available evidence were appraised and summarized. The most high-quality evidence can be found for the use of selective serotonin reuptake inhibitors (SSRIs) and combined oral contraceptives (COCs), with gonadotropin releasing hormone (GnRH) agonists and surgical interventions showing efficacy for refractory cases. While there is some evidence of the efficacy of alternative and complementary medicine treatments such as nutraceuticals, acupuncture, and yoga, variability in quality and methods of studies must be taken into account.

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Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms

Cited by 9 publications

References 8 publications

Effectiveness of Magnesium on Menstrual Symptoms Among Dysmenorrheal College Students: A Randomized Controlled Trial

Effectiveness of Magnesium on Menstrual Symptoms Among Dysmenorrheal College Students: A Randomized Controlled Trial

Hubungan Asupan Vitamin B6 dengan Sindrom Pramenstruasi pada Siswi SMP

Management of Premenstrual Dysphoric Disorder: A Scoping Review

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