Effects of magnesium sulfate on lipid peroxidation and blood pressure regulators in preeclampsia

Ariza, Ana Carolina; Bobadilla, Norma A.; Fernández, Claudia; Muñoz-Fuentes, Rosa María; Larrea, Fernando; Halhali, Ali

doi:10.1016/j.clinbiochem.2004.09.018

Cited by 34 publications

(17 citation statements)

References 22 publications

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“…In addition, cellular data from our group [6] and those from the other group [7] revealed that MgSO 4 possesses potent anti-inflammation capacity, as endotoxin-induced upregulation of inflammatory molecules could be inhibited by MgSO 4 . Moreover, MgSO 4 has been shown to possess potent anti-oxidation capacity, as preeclamptic women treated with MgSO 4 were found to have less lipid peroxidation [8]. This concept is further supported by previous data that hypoxia-induced brain damage in fetal guinea pig [9] and radiation-induced oxidative stress in rat spinal cord [10] could both be attenuated by MgSO 4 .…”

Section: Introductionmentioning

confidence: 81%

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Kao¹,

Jan²,

Tsai³

et al. 2011

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 81%

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Kao¹,

Jan²,

Tsai³

et al. 2011

Journal of Surgical Research

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“…Magnesium inhibits MDA formation in endothelial cells (51) and low [Mg(2ϩ)](o)-induced lipid peroxidation (52). MgSO4 administration to pregnant women induced significant changes in lipid peroxidation (53). This study does have limitations.…”

Section: Discussionmentioning

confidence: 96%

Comparison of the Effects of Vitamins and/or Mineral Supplementation on Glomerular and Tubular Dysfunction in Type 2 Diabetes

et al. 2005

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OBJECTIVE -The present study was designed to assess the effect of magnesium plus zinc, vitamins C plus E, and a combination of these micronutrients on nephropathy indexes in type 2 diabetic patients.RESEARCH DESIGN AND METHODS -In a randomized, double-blind, placebocontrolled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months: group M (n ϭ 16), 200 mg Mg and 30 mg Zn; group V (n ϭ 18), 200 mg vitamin C and 100 IU vitamin E; group MV (n ϭ 17), minerals plus vitamins; and group P (n ϭ 18), placebo. Urinary albumin excretion and N-acetyl-␤-D-glucosaminidase activity (NAG) in urine were determined at the beginning and at the end of the trial. Treatment effects were analyzed by general linear modeling. RESULTS-Results indicate that after 3 months of supplementation, levels of urinary albumin excretion decreased in the V and MV groups (P ϭ 0.034 and P ϭ 0.005, respectively). Urinary NAG activity did not significantly change in any treatment groups. Levels of systolic, diastolic, and mean blood pressure significantly decreased in the MV group (P ϭ 0.008, P ϭ 0.017, and P ϭ 0.009, respectively). Also, combination of vitamin and mineral supplementation had significant effects in decreasing fasting serum glucose (P ϭ 0.035) and malondialdehyde concentrations (P ϭ 0.004) and in increasing HDL cholesterol and apolipoprotein A1 levels (P ϭ 0.019). There was no significant change in the levels of these parameters in the other three groups.CONCLUSIONS -In conclusion, the results of the present study provide evidence for the effects of vitamins C and E and also combination of magnesium, zinc, and vitamins C and E supplementation on improvement of glomerular but not tubular renal function in type 2 diabetic patients. Diabetes Care 28:2458 -2464, 2005D iabetic nephropathy is a serious complication of diabetes and a major cause of mortality and morbidity in these patients (1,2). Results of studies in animal models and humans have demonstrated that diabetes is associated with oxidative stress (3-5) and reduced levels of antioxidants (6). It has been well established that plasma magnesium levels in patients with diabetes is somewhat decreased (7,8). Numerous studies have found decreases in physiological measures of zinc status, hyperzincuria, and indications of zinc malabsorption in diabetic individuals (7,9). Levels of plasma ascorbic acid were found to be significantly lower in diabetic patients compared with nondiabetic control subjects in most studies (10 -12). Based on their results, the researchers observed that individuals with diabetes have significant defects of antioxidant protection, which may enhance their susceptibility to oxidative stress (12).Oxidative stress is hypothesized to play an important part in the development of late diabetes complications (6). Chronic hyperglycemia increases oxidative stress and considerably modifies the structure and function of proteins and lipids, due to glycoxidation and peroxidation...

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“…Mg deficiency could induce high circulating amounts of IL-1, IL-6 and TNF-α, which can further stimulate free radical production in endothelial cells and circulation white blood cells [25]. A small-scale clinical study showed that magnesium treatment results in a significant reduction of serum malondialdehyde, an indicator of lipid peroxidation due to oxidative stress [26]. …”

Section: Discussionmentioning

confidence: 99%

Baseline Serum Magnesium Level and Its Variability in Maintenance Hemodialysis Patients: Associations with Mortality

Cai

Luo

et al. 2019

Kidney Blood Press Res

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Background/Aims: The study aimed at investigating the impact of serum magnesium (Mg) baseline level and its variability on mortality in maintenance hemodialysis (MHD) patients. Methods: Eligible patients receiving regular MHD at Ningbo No. 2 Hospital between January 2009 and August 2016 were enrolled and follow-ups were conducted afterwards until death or transplantation. General information, laboratory results, and outcomes of subjects were collected. The relationship between baseline serum Mg level, its coefficient of variation (CV), and all-cause mortality and cardiovascular disease mortality were assessed, respectively. Subjects were divided into groups in 2 manners: by serum Mg level (lower Mg group: serum Mg <1.00 mmol/L, higher Mg group: serum Mg ≥1.00 mmol/L) and by serum Mg CV (high variation group: CV ≥0.149 mmol/L, middle variation group: 0.114 mmol/L ≤ CV < 0.149 mmol/L, and low variation group: CV <0.114 mmol/L). Results: 169 MHD patients were recruited in the study, with mean serum Mg 1.00 ± 0.18 mmol/L, average age 60.20 ± 15.64 years, and median dialysis duration 37.00 (18.30, 77.97) months. During the follow-up, 69 (40.83%) patients died, 24 (34.78%) of which died due to cardiovascular disease. Comparing the two groups, patients in the lower Mg group had a higher all-cause mortality (50.00 vs. 29.33%, p = 0.007). The multivariate Cox regression analysis suggested that lower Mg level was an independent factor for all-cause mortality as well as cardiovascular mortality (HR = 13.268, 95% CI 6.234–28.237, p < 0.001; HR = 12.702, 95% CI 3.737–43.174, p < 0.001, respectively). However, there were no significant statistical differences of all-cause and cardiovascular mortality among these three groups concerning Mg variation. And in the univariate and multivariate Cox regression analysis, serum magnesium CV was not the independent factor for all-cause mortality and cardiovascular mortality. Conclusions: The lower baseline serum magnesium level was associated with all-cause and cardiovascular mortality in MHD patients. However, the variability of magnesium level was not independently associated with the risk of death and further studies need to be conducted.

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Effects of magnesium sulfate on lipid peroxidation and blood pressure regulators in preeclampsia

Cited by 34 publications

References 22 publications

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Magnesium Sulfate Mitigates Lung Injury Induced by Bilateral Lower Limb Ischemia-Reperfusion in Rats

Comparison of the Effects of Vitamins and/or Mineral Supplementation on Glomerular and Tubular Dysfunction in Type 2 Diabetes

Baseline Serum Magnesium Level and Its Variability in Maintenance Hemodialysis Patients: Associations with Mortality

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